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Items: 1 to 20 of 95

1.

In vivo RNAi screen for BMI1 targets identifies TGF-β/BMP-ER stress pathways as key regulators of neural- and malignant glioma-stem cell homeostasis.

Gargiulo G, Cesaroni M, Serresi M, de Vries N, Hulsman D, Bruggeman SW, Lancini C, van Lohuizen M.

Cancer Cell. 2013 May 13;23(5):660-76. doi: 10.1016/j.ccr.2013.03.030.

2.

Unraveling tumor suppressor networks with in vivo RNAi.

Braun CJ, Hemann MT.

Cell Stem Cell. 2013 Jun 6;12(6):639-41. doi: 10.1016/j.stem.2013.05.020.

3.

Akt phosphorylates the transcriptional repressor bmi1 to block its effects on the tumor-suppressing ink4a-arf locus.

Liu Y, Liu F, Yu H, Zhao X, Sashida G, Deblasio A, Harr M, She QB, Chen Z, Lin HK, Di Giandomenico S, Elf SE, Yang Y, Miyata Y, Huang G, Menendez S, Mellinghoff IK, Rosen N, Pandolfi PP, Hedvat CV, Nimer SD.

Sci Signal. 2012 Oct 23;5(247):ra77. doi: 10.1126/scisignal.2003199.

4.

BMI1 sustains human glioblastoma multiforme stem cell renewal.

Abdouh M, Facchino S, Chatoo W, Balasingam V, Ferreira J, Bernier G.

J Neurosci. 2009 Jul 15;29(28):8884-96. doi: 10.1523/JNEUROSCI.0968-09.2009.

5.

Bmi1 controls tumor development in an Ink4a/Arf-independent manner in a mouse model for glioma.

Bruggeman SW, Hulsman D, Tanger E, Buckle T, Blom M, Zevenhoven J, van Tellingen O, van Lohuizen M.

Cancer Cell. 2007 Oct;12(4):328-41.

6.

Bmi1 promotes hepatic stem cell expansion and tumorigenicity in both Ink4a/Arf-dependent and -independent manners in mice.

Chiba T, Seki A, Aoki R, Ichikawa H, Negishi M, Miyagi S, Oguro H, Saraya A, Kamiya A, Nakauchi H, Yokosuka O, Iwama A.

Hepatology. 2010 Sep;52(3):1111-23. doi: 10.1002/hep.23793.

PMID:
20648475
7.

Bmi1 directly represses p21Waf1/Cip1 in Shh-induced proliferation of cerebellar granule cell progenitors.

Subkhankulova T, Zhang X, Leung C, Marino S.

Mol Cell Neurosci. 2010 Oct;45(2):151-62. doi: 10.1016/j.mcn.2010.06.006.

PMID:
20600931
8.

Bmi1 is required for hepatic progenitor cell expansion and liver tumor development.

Fan L, Xu C, Wang C, Tao J, Ho C, Jiang L, Gui B, Huang S, Evert M, Calvisi DF, Chen X.

PLoS One. 2012;7(9):e46472. doi: 10.1371/journal.pone.0046472.

9.

Conditional activation of Bmi1 expression regulates self-renewal, apoptosis, and differentiation of neural stem/progenitor cells in vitro and in vivo.

Yadirgi G, Leinster V, Acquati S, Bhagat H, Shakhova O, Marino S.

Stem Cells. 2011 Apr;29(4):700-12. doi: 10.1002/stem.614.

10.

A novel zinc finger protein Zfp277 mediates transcriptional repression of the Ink4a/arf locus through polycomb repressive complex 1.

Negishi M, Saraya A, Mochizuki S, Helin K, Koseki H, Iwama A.

PLoS One. 2010 Aug 24;5(8):e12373. doi: 10.1371/journal.pone.0012373.

11.

Polycomb (PcG) proteins, BMI1 and SUZ12, regulate arsenic-induced cell transformation.

Kim HG, Kim DJ, Li S, Lee KY, Li X, Bode AM, Dong Z.

J Biol Chem. 2012 Sep 14;287(38):31920-8. doi: 10.1074/jbc.M112.360362.

12.

BMI1 confers radioresistance to normal and cancerous neural stem cells through recruitment of the DNA damage response machinery.

Facchino S, Abdouh M, Chatoo W, Bernier G.

J Neurosci. 2010 Jul 28;30(30):10096-111. doi: 10.1523/JNEUROSCI.1634-10.2010.

13.

Bmi1 regulates murine intestinal stem cell proliferation and self-renewal downstream of Notch.

López-Arribillaga E, Rodilla V, Pellegrinet L, Guiu J, Iglesias M, Roman AC, Gutarra S, González S, Muñoz-Cánoves P, Fernández-Salguero P, Radtke F, Bigas A, Espinosa L.

Development. 2015 Jan 1;142(1):41-50. doi: 10.1242/dev.107714.

14.

Epigenetic regulation of survivin by Bmi1 is cell type specific during corticogenesis and in gliomas.

Acquati S, Greco A, Licastro D, Bhagat H, Ceric D, Rossini Z, Grieve J, Shaked-Rabi M, Henriquez NV, Brandner S, Stupka E, Marino S.

Stem Cells. 2013 Jan;31(1):190-202. doi: 10.1002/stem.1274.

15.

MicroRNA-128 coordinately targets Polycomb Repressor Complexes in glioma stem cells.

Peruzzi P, Bronisz A, Nowicki MO, Wang Y, Ogawa D, Price R, Nakano I, Kwon CH, Hayes J, Lawler SE, Ostrowski MC, Chiocca EA, Godlewski J.

Neuro Oncol. 2013 Sep;15(9):1212-24. doi: 10.1093/neuonc/not055.

16.

Regulation of hematopoietic stem cells using protein transduction domain-fused Polycomb.

Kajiume T, Sera Y, Kawahara Y, Matsumoto M, Fukazawa T, Imura T, Yuge L, Kobayashi M.

Exp Hematol. 2012 Sep;40(9):751-760.e1. doi: 10.1016/j.exphem.2012.05.005.

PMID:
22634509
17.

Dysregulation of BMI1 and microRNA-16 collaborate to enhance an anti-apoptotic potential in the side population of refractory mantle cell lymphoma.

Teshima K, Nara M, Watanabe A, Ito M, Ikeda S, Hatano Y, Oshima K, Seto M, Sawada K, Tagawa H.

Oncogene. 2014 Apr 24;33(17):2191-203. doi: 10.1038/onc.2013.177.

PMID:
23686310
18.

Transcriptional coactivator Cited2 induces Bmi1 and Mel18 and controls fibroblast proliferation via Ink4a/ARF.

Kranc KR, Bamforth SD, Bragança J, Norbury C, van Lohuizen M, Bhattacharya S.

Mol Cell Biol. 2003 Nov;23(21):7658-66.

19.

BMI1 as a novel target for drug discovery in cancer.

Cao L, Bombard J, Cintron K, Sheedy J, Weetall ML, Davis TW.

J Cell Biochem. 2011 Oct;112(10):2729-41. doi: 10.1002/jcb.23234. Review.

PMID:
21678481
20.

BMI1 represses Ink4a/Arf and Hox genes to regulate stem cells in the rodent incisor.

Biehs B, Hu JK, Strauli NB, Sangiorgi E, Jung H, Heber RP, Ho S, Goodwin AF, Dasen JS, Capecchi MR, Klein OD.

Nat Cell Biol. 2013 Jul;15(7):846-52. doi: 10.1038/ncb2766.

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