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Items: 1 to 20 of 95

1.

X-ray crystal structures of the Escherichia coli RNA polymerase in complex with benzoxazinorifamycins.

Molodtsov V, Nawarathne IN, Scharf NT, Kirchhoff PD, Showalter HD, Garcia GA, Murakami KS.

J Med Chem. 2013 Jun 13;56(11):4758-63. doi: 10.1021/jm4004889.

2.

Structure-based design of novel benzoxazinorifamycins with potent binding affinity to wild-type and rifampin-resistant mutant Mycobacterium tuberculosis RNA polymerases.

Gill SK, Xu H, Kirchhoff PD, Cierpicki T, Turbiak AJ, Wan B, Zhang N, Peng KW, Franzblau SG, Garcia GA, Showalter HD.

J Med Chem. 2012 Apr 26;55(8):3814-26. doi: 10.1021/jm201716n.

PMID:
22452568
3.

Rifamycin inhibition of WT and Rif-resistant Mycobacterium tuberculosis and Escherichia coli RNA polymerases in vitro.

Gill SK, Garcia GA.

Tuberculosis (Edinb). 2011 Sep;91(5):361-9. doi: 10.1016/j.tube.2011.05.002.

PMID:
21704562
4.

The interaction between sigma70 and the beta-flap of Escherichia coli RNA polymerase inhibits extension of nascent RNA during early elongation.

Nickels BE, Garrity SJ, Mekler V, Minakhin L, Severinov K, Ebright RH, Hochschild A.

Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4488-93.

5.

X-ray crystal structure of Escherichia coli RNA polymerase σ70 holoenzyme.

Murakami KS.

J Biol Chem. 2013 Mar 29;288(13):9126-34. doi: 10.1074/jbc.M112.430900.

6.

Structural mechanism for rifampicin inhibition of bacterial rna polymerase.

Campbell EA, Korzheva N, Mustaev A, Murakami K, Nair S, Goldfarb A, Darst SA.

Cell. 2001 Mar 23;104(6):901-12.

7.

Structural basis of transcription initiation: RNA polymerase holoenzyme at 4 A resolution.

Murakami KS, Masuda S, Darst SA.

Science. 2002 May 17;296(5571):1280-4.

8.

Beta subunit residues 186-433 and 436-445 are commonly used by Esigma54 and Esigma70 RNA polymerase for open promoter complex formation.

Wigneshweraraj SR, Nechaev S, Severinov K, Buck M.

J Mol Biol. 2002 Jun 21;319(5):1067-83.

PMID:
12079348
9.

Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins.

Artsimovitch I, Vassylyeva MN, Svetlov D, Svetlov V, Perederina A, Igarashi N, Matsugaki N, Wakatsuki S, Tahirov TH, Vassylyev DG.

Cell. 2005 Aug 12;122(3):351-63.

10.

Mapping the spatial neighborhood of the regulatory 6S RNA bound to Escherichia coli RNA polymerase holoenzyme.

Steuten B, Setny P, Zacharias M, Wagner R.

J Mol Biol. 2013 Oct 9;425(19):3649-61. doi: 10.1016/j.jmb.2013.07.008.

PMID:
23867276
12.

Domain 1.1 of the sigma(70) subunit of Escherichia coli RNA polymerase modulates the formation of stable polymerase/promoter complexes.

Vuthoori S, Bowers CW, McCracken A, Dombroski AJ, Hinton DM.

J Mol Biol. 2001 Jun 8;309(3):561-72.

PMID:
11397080
14.

Crosslink Mapping at Amino Acid-Base Resolution Reveals the Path of Scrunched DNA in Initial Transcribing Complexes.

Winkelman JT, Winkelman BT, Boyce J, Maloney MF, Chen AY, Ross W, Gourse RL.

Mol Cell. 2015 Sep 3;59(5):768-80. doi: 10.1016/j.molcel.2015.06.037.

15.

Isolation and characterization of mutations in region 1.2 of Escherichia coli sigma70.

Baldwin NE, Dombroski AJ.

Mol Microbiol. 2001 Oct;42(2):427-37.

16.

Distinct functions of the RNA polymerase σ subunit region 3.2 in RNA priming and promoter escape.

Pupov D, Kuzin I, Bass I, Kulbachinskiy A.

Nucleic Acids Res. 2014 Apr;42(7):4494-504. doi: 10.1093/nar/gkt1384.

17.

Bacterial RNA polymerase: a promising target for the discovery of new antimicrobial agents.

Chopra I.

Curr Opin Investig Drugs. 2007 Aug;8(8):600-7. Review.

PMID:
17668362
18.

Structure of a ternary transcription activation complex.

Jain D, Nickels BE, Sun L, Hochschild A, Darst SA.

Mol Cell. 2004 Jan 16;13(1):45-53.

19.

Free RNA polymerase in Escherichia coli.

Patrick M, Dennis PP, Ehrenberg M, Bremer H.

Biochimie. 2015 Dec;119:80-91. doi: 10.1016/j.biochi.2015.10.015.

PMID:
26482806
20.

Structural basis of transcription initiation: an RNA polymerase holoenzyme-DNA complex.

Murakami KS, Masuda S, Campbell EA, Muzzin O, Darst SA.

Science. 2002 May 17;296(5571):1285-90.

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