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ADAM17 mediates Nox4 expression and NADPH oxidase activity in the kidney cortex of OVE26 mice.

Ford BM, Eid AA, Göőz M, Barnes JL, Gorin YC, Abboud HE.

Am J Physiol Renal Physiol. 2013 Aug 1;305(3):F323-32. doi: 10.1152/ajprenal.00522.2012.


Critical role of Nox4-based NADPH oxidase in glucose-induced oxidative stress in the kidney: implications in type 2 diabetic nephropathy.

Sedeek M, Callera G, Montezano A, Gutsol A, Heitz F, Szyndralewiez C, Page P, Kennedy CR, Burns KD, Touyz RM, Hébert RL.

Am J Physiol Renal Physiol. 2010 Dec;299(6):F1348-58. doi: 10.1152/ajprenal.00028.2010.


Targeting NADPH oxidase with a novel dual Nox1/Nox4 inhibitor attenuates renal pathology in type 1 diabetes.

Gorin Y, Cavaglieri RC, Khazim K, Lee DY, Bruno F, Thakur S, Fanti P, Szyndralewiez C, Barnes JL, Block K, Abboud HE.

Am J Physiol Renal Physiol. 2015 Jun 1;308(11):F1276-87. doi: 10.1152/ajprenal.00396.2014.


Nox4 NAD(P)H oxidase mediates hypertrophy and fibronectin expression in the diabetic kidney.

Gorin Y, Block K, Hernandez J, Bhandari B, Wagner B, Barnes JL, Abboud HE.

J Biol Chem. 2005 Nov 25;280(47):39616-26.


Plumbagin ameliorates diabetic nephropathy via interruption of pathways that include NOX4 signalling.

Yong R, Chen XM, Shen S, Vijayaraj S, Ma Q, Pollock CA, Saad S.

PLoS One. 2013 Aug 26;8(8):e73428. doi: 10.1371/journal.pone.0073428.


Thioredoxin-interacting protein mediates high glucose-induced reactive oxygen species generation by mitochondria and the NADPH oxidase, Nox4, in mesangial cells.

Shah A, Xia L, Goldberg H, Lee KW, Quaggin SE, Fantus IG.

J Biol Chem. 2013 Mar 8;288(10):6835-48. doi: 10.1074/jbc.M112.419101.


IGF-I increases the expression of fibronectin by Nox4-dependent Akt phosphorylation in renal tubular epithelial cells.

New DD, Block K, Bhandhari B, Gorin Y, Abboud HE.

Am J Physiol Cell Physiol. 2012 Jan 1;302(1):C122-30. doi: 10.1152/ajpcell.00141.2011.


RhoA/Rho kinase mediates TGF-β1-induced kidney myofibroblast activation through Poldip2/Nox4-derived reactive oxygen species.

Manickam N, Patel M, Griendling KK, Gorin Y, Barnes JL.

Am J Physiol Renal Physiol. 2014 Jul 15;307(2):F159-71. doi: 10.1152/ajprenal.00546.2013.


Subcellular localization of Nox4 and regulation in diabetes.

Block K, Gorin Y, Abboud HE.

Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14385-90. doi: 10.1073/pnas.0906805106.


The antioxidant silybin prevents high glucose-induced oxidative stress and podocyte injury in vitro and in vivo.

Khazim K, Gorin Y, Cavaglieri RC, Abboud HE, Fanti P.

Am J Physiol Renal Physiol. 2013 Sep 1;305(5):F691-700. doi: 10.1152/ajprenal.00028.2013.


Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of Type 2 diabetes.

Sedeek M, Gutsol A, Montezano AC, Burger D, Nguyen Dinh Cat A, Kennedy CR, Burns KD, Cooper ME, Jandeleit-Dahm K, Page P, Szyndralewiez C, Heitz F, Hebert RL, Touyz RM.

Clin Sci (Lond). 2013 Feb;124(3):191-202. doi: 10.1042/CS20120330.


Upregulation of Nox4 promotes angiotensin II-induced epidermal growth factor receptor activation and subsequent cardiac hypertrophy by increasing ADAM17 expression.

Zeng SY, Chen X, Chen SR, Li Q, Wang YH, Zou J, Cao WW, Luo JN, Gao H, Liu PQ.

Can J Cardiol. 2013 Oct;29(10):1310-9. doi: 10.1016/j.cjca.2013.04.026.


Inactivation of AMPK mediates high phosphate-induced extracellular matrix accumulation via NOX4/TGFß-1 signaling in human mesangial cells.

Papadimitriou A, Peixoto EB, Silva KC, Lopes de Faria JM, Lopes de Faria JB.

Cell Physiol Biochem. 2014;34(4):1260-72. doi: 10.1159/000366336.


Genetic targeting or pharmacologic inhibition of NADPH oxidase nox4 provides renoprotection in long-term diabetic nephropathy.

Jha JC, Gray SP, Barit D, Okabe J, El-Osta A, Namikoshi T, Thallas-Bonke V, Wingler K, Szyndralewiez C, Heitz F, Touyz RM, Cooper ME, Schmidt HH, Jandeleit-Dahm KA.

J Am Soc Nephrol. 2014 Jun;25(6):1237-54. doi: 10.1681/ASN.2013070810.


Glycated albumin triggers fibrosis and apoptosis via an NADPH oxidase/Nox4-MAPK pathway-dependent mechanism in renal proximal tubular cells.

Qi W, Niu J, Qin Q, Qiao Z, Gu Y.

Mol Cell Endocrinol. 2015 Apr 15;405:74-83. doi: 10.1016/j.mce.2015.02.007.


Nox4-derived reactive oxygen species mediate cardiomyocyte injury in early type 1 diabetes.

Maalouf RM, Eid AA, Gorin YC, Block K, Escobar GP, Bailey S, Abboud HE.

Am J Physiol Cell Physiol. 2012 Feb 1;302(3):C597-604. doi: 10.1152/ajpcell.00331.2011.


ATP-mediated activation of the NADPH oxidase DUOX1 mediates airway epithelial responses to bacterial stimuli.

Boots AW, Hristova M, Kasahara DI, Haenen GR, Bast A, van der Vliet A.

J Biol Chem. 2009 Jun 26;284(26):17858-67. doi: 10.1074/jbc.M809761200.


Mitochondria-targeted peptide SS-31 attenuates renal injury via an antioxidant effect in diabetic nephropathy.

Hou Y, Li S, Wu M, Wei J, Ren Y, Du C, Wu H, Han C, Duan H, Shi Y.

Am J Physiol Renal Physiol. 2016 Mar 15;310(6):F547-59. doi: 10.1152/ajprenal.00574.2014.


Nicotinamide adenine dinucleotide phosphate oxidase 4 mediates the differential responsiveness of atrial versus ventricular fibroblasts to transforming growth factor-β.

Yeh YH, Kuo CT, Chang GJ, Qi XY, Nattel S, Chen WJ.

Circ Arrhythm Electrophysiol. 2013 Aug;6(4):790-8. doi: 10.1161/CIRCEP.113.000338.


Mechanisms of podocyte injury in diabetes: role of cytochrome P450 and NADPH oxidases.

Eid AA, Gorin Y, Fagg BM, Maalouf R, Barnes JL, Block K, Abboud HE.

Diabetes. 2009 May;58(5):1201-11. doi: 10.2337/db08-1536.

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