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Cyclophosphamide triggers follicle activation and "burnout"; AS101 prevents follicle loss and preserves fertility.

Kalich-Philosoph L, Roness H, Carmely A, Fishel-Bartal M, Ligumsky H, Paglin S, Wolf I, Kanety H, Sredni B, Meirow D.

Sci Transl Med. 2013 May 15;5(185):185ra62. doi: 10.1126/scitranslmed.3005402.


Rapamycin Prevents cyclophosphamide-induced Over-activation of Primordial Follicle pool through PI3K/Akt/mTOR Signaling Pathway in vivo.

Zhou L, Xie Y, Li S, Liang Y, Qiu Q, Lin H, Zhang Q.

J Ovarian Res. 2017 Aug 16;10(1):56. doi: 10.1186/s13048-017-0350-3.


AMH prevents primordial ovarian follicle loss and fertility alteration in cyclophosphamide-treated mice.

Sonigo C, Beau I, Grynberg M, Binart N.

FASEB J. 2019 Jan;33(1):1278-1287. doi: 10.1096/fj.201801089R. Epub 2018 Aug 16.


Follicle Loss and Apoptosis in Cyclophosphamide-Treated Mice: What's the Matter?

Chen XY, Xia HX, Guan HY, Li B, Zhang W.

Int J Mol Sci. 2016 May 30;17(6). pii: E836. doi: 10.3390/ijms17060836.


Ceramide-1-phosphate has protective properties against cyclophosphamide-induced ovarian damage in a mice model of premature ovarian failure.

Pascuali N, Scotti L, Di Pietro M, Oubiña G, Bas D, May M, Gómez Muñoz A, Cuasnicú PS, Cohen DJ, Tesone M, Abramovich D, Parborell F.

Hum Reprod. 2018 May 1;33(5):844-859. doi: 10.1093/humrep/dey045.


Melatonin prevents cisplatin-induced primordial follicle loss via suppression of PTEN/AKT/FOXO3a pathway activation in the mouse ovary.

Jang H, Lee OH, Lee Y, Yoon H, Chang EM, Park M, Lee JW, Hong K, Kim JO, Kim NK, Ko JJ, Lee DR, Yoon TK, Lee WS, Choi Y.

J Pineal Res. 2016 Apr;60(3):336-47. doi: 10.1111/jpi.12316. Epub 2016 Mar 2.


Protective effect of the immunomodulator AS101 against cyclophosphamide-induced testicular damage in mice.

Carmely A, Meirow D, Peretz A, Albeck M, Bartoov B, Sredni B.

Hum Reprod. 2009 Jun;24(6):1322-9. doi: 10.1093/humrep/den481. Epub 2009 Feb 24.


Pharmacological inhibition of mTORC1 prevents over-activation of the primordial follicle pool in response to elevated PI3K signaling.

Adhikari D, Risal S, Liu K, Shen Y.

PLoS One. 2013;8(1):e53810. doi: 10.1371/journal.pone.0053810. Epub 2013 Jan 11.


Sphingosine-1-phosphate prevents chemotherapy-induced human primordial follicle death.

Li F, Turan V, Lierman S, Cuvelier C, De Sutter P, Oktay K.

Hum Reprod. 2014 Jan;29(1):107-13. doi: 10.1093/humrep/det391. Epub 2013 Nov 12.


Loss of PUMA protects the ovarian reserve during DNA-damaging chemotherapy and preserves fertility.

Nguyen QN, Zerafa N, Liew SH, Morgan FH, Strasser A, Scott CL, Findlay JK, Hickey M, Hutt KJ.

Cell Death Dis. 2018 May 23;9(6):618. doi: 10.1038/s41419-018-0633-7.


Does controlled ovarian stimulation prior to chemotherapy increase primordial follicle loss and diminish ovarian reserve? An animal study.

Maman E, Prokopis K, Levron J, Carmely A, Dor J, Meirow D.

Hum Reprod. 2009 Jan;24(1):206-10. doi: 10.1093/humrep/den337. Epub 2008 Oct 14.


Prevention of cyclophosphamide-induced ovarian damage by concomitant administration of GnRHa in mice: a dose-dependent relationship?

Yüce MA, Balkanli Kaplan P, Gücer F, Doğanay L, Altaner S, Canda T, Yardim T.

Eur J Gynaecol Oncol. 2004;25(5):628-31.


Folliculogenesis Is Not Fully Inhibited during GnRH Analogues Treatment in Mice Challenging Their Efficiency to Preserve the Ovarian Reserve during Chemotherapy in This Model.

Horicks F, Van Den Steen G, Houben S, Englert Y, Demeestere I.

PLoS One. 2015 Sep 1;10(9):e0137164. doi: 10.1371/journal.pone.0137164. eCollection 2015.


Cisplatin Induces Overactivation of the Dormant Primordial Follicle through PTEN/AKT/FOXO3a Pathway which Leads to Loss of Ovarian Reserve in Mice.

Chang EM, Lim E, Yoon S, Jeong K, Bae S, Lee DR, Yoon TK, Choi Y, Lee WS.

PLoS One. 2015 Dec 14;10(12):e0144245. doi: 10.1371/journal.pone.0144245. eCollection 2015.


Understanding the Villain: DMBA-induced preantral ovotoxicity involves selective follicular destruction and primordial follicle activation through PI3K/Akt and mTOR signaling.

Sobinoff AP, Mahony M, Nixon B, Roman SD, McLaughlin EA.

Toxicol Sci. 2011 Oct;123(2):563-75. doi: 10.1093/toxsci/kfr195. Epub 2011 Jul 23.


Phosphoinositide 3-kinase p110δ mediates estrogen- and FSH-stimulated ovarian follicle growth.

Li Q, He H, Zhang YL, Li XM, Guo X, Huo R, Bi Y, Li J, Fan HY, Sha J.

Mol Endocrinol. 2013 Sep;27(9):1468-82. doi: 10.1210/me.2013-1082. Epub 2013 Jul 2.


The GnRH antagonist cetrorelix reduces cyclophosphamide-induced ovarian follicular destruction in mice.

Meirow D, Assad G, Dor J, Rabinovici J.

Hum Reprod. 2004 Jun;19(6):1294-9. Epub 2004 Apr 29.


New strategy for in vitro activation of primordial follicles with mTOR and PI3K stimulators.

Sun X, Su Y, He Y, Zhang J, Liu W, Zhang H, Hou Z, Liu J, Li J.

Cell Cycle. 2015;14(5):721-31. doi: 10.1080/15384101.2014.995496.


Rapamycin-sensitive mTORC1 signaling is involved in physiological primordial follicle activation in mouse ovary.

Tong Y, Li F, Lu Y, Cao Y, Gao J, Liu J.

Mol Reprod Dev. 2013 Dec;80(12):1018-34.


mTORC1/2 inhibition preserves ovarian function and fertility during genotoxic chemotherapy.

Goldman KN, Chenette D, Arju R, Duncan FE, Keefe DL, Grifo JA, Schneider RJ.

Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3186-3191. doi: 10.1073/pnas.1617233114. Epub 2017 Mar 7.

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