Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 123

1.

Semisynthesis, cytotoxicity, antiviral activity, and drug interaction liability of 7-O-methylated analogues of flavonolignans from milk thistle.

Althagafy HS, Graf TN, Sy-Cordero AA, Gufford BT, Paine MF, Wagoner J, Polyak SJ, Croatt MP, Oberlies NH.

Bioorg Med Chem. 2013 Jul 1;21(13):3919-26. doi: 10.1016/j.bmc.2013.04.017. Epub 2013 Apr 16.

2.

Enhanced bioactivity of silybin B methylation products.

Sy-Cordero AA, Graf TN, Runyon SP, Wani MC, Kroll DJ, Agarwal R, Brantley SJ, Paine MF, Polyak SJ, Oberlies NH.

Bioorg Med Chem. 2013 Feb 1;21(3):742-7. doi: 10.1016/j.bmc.2012.11.035. Epub 2012 Dec 5.

3.

Two flavonolignans from milk thistle (Silybum marianum) inhibit CYP2C9-mediated warfarin metabolism at clinically achievable concentrations.

Brantley SJ, Oberlies NH, Kroll DJ, Paine MF.

J Pharmacol Exp Ther. 2010 Mar;332(3):1081-7. doi: 10.1124/jpet.109.161927. Epub 2009 Nov 24.

4.

Assessment of a dry extract from milk thistle (Silybum marianum) for interference with human liver cytochrome-P450 activities.

Doehmer J, Weiss G, McGregor GP, Appel K.

Toxicol In Vitro. 2011 Feb;25(1):21-7. doi: 10.1016/j.tiv.2010.09.001. Epub 2010 Sep 7.

PMID:
20828605
5.

The effect of milk thistle (Silybum marianum) and its main flavonolignans on CYP2C8 enzyme activity in human liver microsomes.

Albassam AA, Frye RF, Markowitz JS.

Chem Biol Interact. 2017 Jun 1;271:24-29. doi: 10.1016/j.cbi.2017.04.025. Epub 2017 Apr 27.

PMID:
28457856
6.

Identification of hepatoprotective flavonolignans from silymarin.

Polyak SJ, Morishima C, Lohmann V, Pal S, Lee DY, Liu Y, Graf TN, Oberlies NH.

Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5995-9. doi: 10.1073/pnas.0914009107. Epub 2010 Mar 15.

7.

Drug-drug interactions of silymarin on the perspective of pharmacokinetics.

Wu JW, Lin LC, Tsai TH.

J Ethnopharmacol. 2009 Jan 21;121(2):185-93. doi: 10.1016/j.jep.2008.10.036. Epub 2008 Nov 8. Review.

PMID:
19041708
8.

The effects of milk thistle (Silybum marianum) on human cytochrome P450 activity.

Kawaguchi-Suzuki M, Frye RF, Zhu HJ, Brinda BJ, Chavin KD, Bernstein HJ, Markowitz JS.

Drug Metab Dispos. 2014 Oct;42(10):1611-6. doi: 10.1124/dmd.114.057232. Epub 2014 Jul 15.

9.

Silymarin for HCV infection.

Polyak SJ, Oberlies NH, Pécheur EI, Dahari H, Ferenci P, Pawlotsky JM.

Antivir Ther. 2013;18(2):141-7. doi: 10.3851/IMP2402. Epub 2012 Sep 25. Review.

10.

Flavonolignans from Aspergillus iizukae, a fungal endophyte of milk thistle (Silybum marianum).

El-Elimat T, Raja HA, Graf TN, Faeth SH, Cech NB, Oberlies NH.

J Nat Prod. 2014 Feb 28;77(2):193-9. doi: 10.1021/np400955q. Epub 2014 Jan 23.

PMID:
24456525
11.

Recent advances in the analysis of flavonolignans of Silybum marianum.

Csupor D, Csorba A, Hohmann J.

J Pharm Biomed Anal. 2016 Oct 25;130:301-317. doi: 10.1016/j.jpba.2016.05.034. Epub 2016 May 26. Review.

PMID:
27321822
12.

Inhibition of HCV 3a core gene through Silymarin and its fractions.

Ashfaq UA, Javed T, Rehman S, Nawaz Z, Riazuddin S.

Virol J. 2011 Apr 1;8:153. doi: 10.1186/1743-422X-8-153.

13.

Effect of silybin and its congeners on human liver microsomal cytochrome P450 activities.

Zuber R, Modrianský M, Dvorák Z, Rohovský P, Ulrichová J, Simánek V, Anzenbacher P.

Phytother Res. 2002 Nov;16(7):632-8.

PMID:
12410543
14.

Chemistry of silybin.

Biedermann D, Vavříková E, Cvak L, Křen V.

Nat Prod Rep. 2014 Sep;31(9):1138-57. doi: 10.1039/c3np70122k. Review.

PMID:
24977260
15.

Milk thistle, a herbal supplement, decreases the activity of CYP3A4 and uridine diphosphoglucuronosyl transferase in human hepatocyte cultures.

Venkataramanan R, Ramachandran V, Komoroski BJ, Zhang S, Schiff PL, Strom SC.

Drug Metab Dispos. 2000 Nov;28(11):1270-3.

16.

Large-scale isolation of flavonolignans from Silybum marianum extract affords new minor constituents and preliminary structure-activity relationships.

Sy-Cordero A, Graf TN, Nakanishi Y, Wani MC, Agarwal R, Kroll DJ, Oberlies NH.

Planta Med. 2010 Apr;76(6):644-7. doi: 10.1055/s-0029-1240624. Epub 2009 Nov 25.

17.

Milk thistle and prostate cancer: differential effects of pure flavonolignans from Silybum marianum on antiproliferative end points in human prostate carcinoma cells.

Davis-Searles PR, Nakanishi Y, Kim NC, Graf TN, Oberlies NH, Wani MC, Wall ME, Agarwal R, Kroll DJ.

Cancer Res. 2005 May 15;65(10):4448-57.

18.

The in-vitro effect of complementary and alternative medicines on cytochrome P450 2C9 activity.

Mooiman KD, Goey AK, Huijbregts TJ, Maas-Bakker RF, Beijnen JH, Schellens JH, Meijerman I.

J Pharm Pharmacol. 2014 Sep;66(9):1339-46. doi: 10.1111/jphp.12259. Epub 2014 Apr 15.

PMID:
24730468
19.

Evidence for differences in regioselective and stereoselective glucuronidation of silybin diastereomers from milk thistle (Silybum marianum) by human UDP-glucuronosyltransferases.

Jančová P, Siller M, Anzenbacherová E, Křen V, Anzenbacher P, Simánek V.

Xenobiotica. 2011 Sep;41(9):743-51. doi: 10.3109/00498254.2011.573017. Epub 2011 Apr 27.

PMID:
21524189
20.

Pharmacokinetics and metabolic profile of free, conjugated, and total silymarin flavonolignans in human plasma after oral administration of milk thistle extract.

Wen Z, Dumas TE, Schrieber SJ, Hawke RL, Fried MW, Smith PC.

Drug Metab Dispos. 2008 Jan;36(1):65-72. Epub 2007 Oct 3.

Supplemental Content

Support Center