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Metastasis suppressor, NDRG1, mediates its activity through signaling pathways and molecular motors.

Sun J, Zhang D, Bae DH, Sahni S, Jansson P, Zheng Y, Zhao Q, Yue F, Zheng M, Kovacevic Z, Richardson DR.

Carcinogenesis. 2013 Sep;34(9):1943-54. doi: 10.1093/carcin/bgt163. Epub 2013 May 13. Review.


Dp44mT targets the AKT, TGF-β and ERK pathways via the metastasis suppressor NDRG1 in normal prostate epithelial cells and prostate cancer cells.

Dixon KM, Lui GY, Kovacevic Z, Zhang D, Yao M, Chen Z, Dong Q, Assinder SJ, Richardson DR.

Br J Cancer. 2013 Feb 5;108(2):409-19. doi: 10.1038/bjc.2012.582. Epub 2013 Jan 3.


The iron-regulated metastasis suppressor NDRG1 targets NEDD4L, PTEN, and SMAD4 and inhibits the PI3K and Ras signaling pathways.

Kovacevic Z, Chikhani S, Lui GY, Sivagurunathan S, Richardson DR.

Antioxid Redox Signal. 2013 Mar 10;18(8):874-87. doi: 10.1089/ars.2011.4273. Epub 2012 May 8.


The metastasis suppressor NDRG1 modulates the phosphorylation and nuclear translocation of β-catenin through mechanisms involving FRAT1 and PAK4.

Jin R, Liu W, Menezes S, Yue F, Zheng M, Kovacevic Z, Richardson DR.

J Cell Sci. 2014 Jul 15;127(Pt 14):3116-30. doi: 10.1242/jcs.147835. Epub 2014 May 14.


The iron chelators Dp44mT and DFO inhibit TGF-β-induced epithelial-mesenchymal transition via up-regulation of N-Myc downstream-regulated gene 1 (NDRG1).

Chen Z, Zhang D, Yue F, Zheng M, Kovacevic Z, Richardson DR.

J Biol Chem. 2012 May 18;287(21):17016-28. doi: 10.1074/jbc.M112.350470. Epub 2012 Mar 27.


Targeting the metastasis suppressor, NDRG1, using novel iron chelators: regulation of stress fiber-mediated tumor cell migration via modulation of the ROCK1/pMLC2 signaling pathway.

Sun J, Zhang D, Zheng Y, Zhao Q, Zheng M, Kovacevic Z, Richardson DR.

Mol Pharmacol. 2013 Feb;83(2):454-69. doi: 10.1124/mol.112.083097. Epub 2012 Nov 27.


Novel Thiosemicarbazones Inhibit Lysine-Rich Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) Coisolated (LYRIC) and the LYRIC-Induced Epithelial-Mesenchymal Transition via Upregulation of N-Myc Downstream-Regulated Gene 1 (NDRG1).

Xi R, Pun IH, Menezes SV, Fouani L, Kalinowski DS, Huang ML, Zhang X, Richardson DR, Kovacevic Z.

Mol Pharmacol. 2017 May;91(5):499-517. doi: 10.1124/mol.116.107870. Epub 2017 Mar 8.


The metastasis suppressor, N-myc downstream regulated gene 1 (NDRG1), upregulates p21 via p53-independent mechanisms.

Kovacevic Z, Sivagurunathan S, Mangs H, Chikhani S, Zhang D, Richardson DR.

Carcinogenesis. 2011 May;32(5):732-40. doi: 10.1093/carcin/bgr046. Epub 2011 Mar 11.


The Metastasis Suppressor, N-MYC Downstream-regulated Gene-1 (NDRG1), Down-regulates the ErbB Family of Receptors to Inhibit Downstream Oncogenic Signaling Pathways.

Kovacevic Z, Menezes SV, Sahni S, Kalinowski DS, Bae DH, Lane DJ, Richardson DR.

J Biol Chem. 2016 Jan 15;291(3):1029-52. doi: 10.1074/jbc.M115.689653. Epub 2015 Nov 3.


Overexpression of N-myc downstream-regulated gene 1 inhibits human glioma proliferation and invasion via phosphoinositide 3-kinase/AKT pathways.

Ma W, Na M, Tang C, Wang H, Lin Z.

Mol Med Rep. 2015 Jul;12(1):1050-8. doi: 10.3892/mmr.2015.3492. Epub 2015 Mar 13.


N-myc downstream regulated 1 gene and its place in the cellular machinery.

Kitowska A, Pawełczyk T.

Acta Biochim Pol. 2010;57(1):15-21. Epub 2010 Mar 19. Review.


The role of NDRG1 in the pathology and potential treatment of human cancers.

Bae DH, Jansson PJ, Huang ML, Kovacevic Z, Kalinowski D, Lee CS, Sahni S, Richardson DR.

J Clin Pathol. 2013 Nov;66(11):911-7. doi: 10.1136/jclinpath-2013-201692. Epub 2013 Jun 8. Review.


Molecular functions of the iron-regulated metastasis suppressor, NDRG1, and its potential as a molecular target for cancer therapy.

Fang BA, Kovačević Ž, Park KC, Kalinowski DS, Jansson PJ, Lane DJ, Sahni S, Richardson DR.

Biochim Biophys Acta. 2014 Jan;1845(1):1-19. doi: 10.1016/j.bbcan.2013.11.002. Epub 2013 Nov 21. Review.


The proto-oncogene c-Src and its downstream signaling pathways are inhibited by the metastasis suppressor, NDRG1.

Liu W, Yue F, Zheng M, Merlot A, Bae DH, Huang M, Lane D, Jansson P, Lui GY, Richardson V, Sahni S, Kalinowski D, Kovacevic Z, Richardson DR.

Oncotarget. 2015 Apr 20;6(11):8851-74.


The metastasis suppressor, N-myc downstream-regulated gene 1 (NDRG1), inhibits stress-induced autophagy in cancer cells.

Sahni S, Bae DH, Lane DJ, Kovacevic Z, Kalinowski DS, Jansson PJ, Richardson DR.

J Biol Chem. 2014 Apr 4;289(14):9692-709. doi: 10.1074/jbc.M113.529511. Epub 2014 Feb 15.


The metastasis suppressor, NDRG1, inhibits "stemness" of colorectal cancer via down-regulation of nuclear β-catenin and CD44.

Wangpu X, Yang X, Zhao J, Lu J, Guan S, Lu J, Kovacevic Z, Liu W, Mi L, Jin R, Sun J, Yue F, Ma J, Lu A, Richardson DR, Wang L, Zheng M.

Oncotarget. 2015 Oct 20;6(32):33893-911. doi: 10.18632/oncotarget.5294.


N-myc downstream regulated gene 1 (NDRG1) promotes metastasis of human scirrhous gastric cancer cells through epithelial mesenchymal transition.

Ureshino H, Murakami Y, Watari K, Izumi H, Kawahara A, Kage M, Arao T, Nishio K, Yanagihara K, Kinoshita H, Kuwano M, Ono M.

PLoS One. 2012;7(7):e41312. doi: 10.1371/journal.pone.0041312. Epub 2012 Jul 23.


Activation of RAF/MEK/ERK and PI3K/AKT/mTOR pathways in pituitary adenomas and their effects on downstream effectors.

Dworakowska D, Wlodek E, Leontiou CA, Igreja S, Cakir M, Teng M, Prodromou N, Góth MI, Grozinsky-Glasberg S, Gueorguiev M, Kola B, Korbonits M, Grossman AB.

Endocr Relat Cancer. 2009 Dec;16(4):1329-38. doi: 10.1677/ERC-09-0101. Epub 2009 Jul 20.


Identification of NDRG1-regulated genes associated with invasive potential in cervical and ovarian cancer cells.

Zhao G, Chen J, Deng Y, Gao F, Zhu J, Feng Z, Lv X, Zhao Z.

Biochem Biophys Res Commun. 2011 Apr 29;408(1):154-9. doi: 10.1016/j.bbrc.2011.03.140. Epub 2011 Apr 2.


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