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Kallistatin antagonizes Wnt/β-catenin signaling and cancer cell motility via binding to low-density lipoprotein receptor-related protein 6.

Zhang J, Yang Z, Li P, Bledsoe G, Chao L, Chao J.

Mol Cell Biochem. 2013 Jul;379(1-2):295-301. doi: 10.1007/s11010-013-1654-2.


Kallistatin induces breast cancer cell apoptosis and autophagy by modulating Wnt signaling and microRNA synthesis.

Li P, Guo Y, Bledsoe G, Yang Z, Chao L, Chao J.

Exp Cell Res. 2016 Jan 15;340(2):305-14. doi: 10.1016/j.yexcr.2016.01.004.


Niclosamide suppresses cancer cell growth by inducing Wnt co-receptor LRP6 degradation and inhibiting the Wnt/β-catenin pathway.

Lu W, Lin C, Roberts MJ, Waud WR, Piazza GA, Li Y.

PLoS One. 2011;6(12):e29290. doi: 10.1371/journal.pone.0029290.


Cripto-1 enhances the canonical Wnt/β-catenin signaling pathway by binding to LRP5 and LRP6 co-receptors.

Nagaoka T, Karasawa H, Turbyville T, Rangel MC, Castro NP, Gonzales M, Baker A, Seno M, Lockett S, Greer YE, Rubin JS, Salomon DS, Bianco C.

Cell Signal. 2013 Jan;25(1):178-89. doi: 10.1016/j.cellsig.2012.09.024.


Antiangiogenic and antineuroinflammatory effects of kallistatin through interactions with the canonical Wnt pathway.

Liu X, Zhang B, McBride JD, Zhou K, Lee K, Zhou Y, Liu Z, Ma JX.

Diabetes. 2013 Dec;62(12):4228-38. doi: 10.2337/db12-1710.


Nanoparticle-mediated expression of a Wnt pathway inhibitor ameliorates ocular neovascularization.

Wang Z, Cheng R, Lee K, Tyagi P, Ding L, Kompella UB, Chen J, Xu X, Ma JX.

Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):855-64. doi: 10.1161/ATVBAHA.114.304627.


Silibinin inhibits Wnt/β-catenin signaling by suppressing Wnt co-receptor LRP6 expression in human prostate and breast cancer cells.

Lu W, Lin C, King TD, Chen H, Reynolds RC, Li Y.

Cell Signal. 2012 Dec;24(12):2291-6. doi: 10.1016/j.cellsig.2012.07.009.


Effect of pantoprazole on human gastric adenocarcinoma SGC7901 cells through regulation of phospho‑LRP6 expression in Wnt/β-catenin signaling.

Shen W, Zou X, Chen M, Shen Y, Huang S, Guo H, Zhang L, Liu P.

Oncol Rep. 2013 Aug;30(2):851-5. doi: 10.3892/or.2013.2524.


Protein kinase C delta negatively modulates canonical Wnt pathway and cell proliferation in colon tumor cell lines.

Hernández-Maqueda JG, Luna-Ulloa LB, Santoyo-Ramos P, Castañeda-Patlán MC, Robles-Flores M.

PLoS One. 2013;8(3):e58540. doi: 10.1371/journal.pone.0058540.


Oncogenic KRAS signalling promotes the Wnt/β-catenin pathway through LRP6 in colorectal cancer.

Lemieux E, Cagnol S, Beaudry K, Carrier J, Rivard N.

Oncogene. 2015 Sep 17;34(38):4914-27. doi: 10.1038/onc.2014.416.


β-arrestin promotes Wnt-induced low density lipoprotein receptor-related protein 6 (Lrp6) phosphorylation via increased membrane recruitment of Amer1 protein.

Kríz V, Pospíchalová V, Masek J, Kilander MB, Slavík J, Tanneberger K, Schulte G, Machala M, Kozubík A, Behrens J, Bryja V.

J Biol Chem. 2014 Jan 10;289(2):1128-41. doi: 10.1074/jbc.M113.498444.


EMILIN2 down-modulates the Wnt signalling pathway and suppresses breast cancer cell growth and migration.

Marastoni S, Andreuzzi E, Paulitti A, Colladel R, Pellicani R, Todaro F, Schiavinato A, Bonaldo P, Colombatti A, Mongiat M.

J Pathol. 2014 Mar;232(4):391-404. doi: 10.1002/path.4316.


Receptor tyrosine kinase-like orphan receptor 2 (Ror2) expression creates a poised state of Wnt signaling in renal cancer.

Rasmussen NR, Wright TM, Brooks SA, Hacker KE, Debebe Z, Sendor AB, Walker MP, Major MB, Green J, Wahl GM, Rathmell WK.

J Biol Chem. 2013 Sep 6;288(36):26301-10. doi: 10.1074/jbc.M113.466086.


Upregulation of the Wnt co-receptor LRP6 promotes hepatocarcinogenesis and enhances cell invasion.

Tung EK, Wong BY, Yau TO, Ng IO.

PLoS One. 2012;7(5):e36565. doi: 10.1371/journal.pone.0036565.


Modulation of canonical Wnt signaling by the extracellular matrix component biglycan.

Berendsen AD, Fisher LW, Kilts TM, Owens RT, Robey PG, Gutkind JS, Young MF.

Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):17022-7. doi: 10.1073/pnas.1110629108.


Tyrosine-based signal mediates LRP6 receptor endocytosis and desensitization of Wnt/β-catenin pathway signaling.

Liu CC, Kanekiyo T, Roth B, Bu G.

J Biol Chem. 2014 Oct 3;289(40):27562-70. doi: 10.1074/jbc.M113.533927.


Inhibition by chondroitin sulfate E can specify functional Wnt/β-catenin signaling thresholds in NIH3T3 fibroblasts.

Willis CM, Klüppel M.

J Biol Chem. 2012 Oct 26;287(44):37042-56. doi: 10.1074/jbc.M112.391490.


Wnt signaling in age-related macular degeneration: human macular tissue and mouse model.

Tuo J, Wang Y, Cheng R, Li Y, Chen M, Qiu F, Qian H, Shen D, Penalva R, Xu H, Ma JX, Chan CC.

J Transl Med. 2015 Oct 17;13:330. doi: 10.1186/s12967-015-0683-x.

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