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Decreased fasting blood glucose is associated with impaired hepatic glucose production in thyroid-stimulating hormone receptor knockout mice.

Wang T, Xu J, Bo T, Zhou X, Jiang X, Gao L, Zhao J.

Endocr J. 2013;60(8):941-50. Epub 2013 May 10.


Thyrotropin increases hepatic triglyceride content through upregulation of SREBP-1c activity.

Yan F, Wang Q, Lu M, Chen W, Song Y, Jing F, Guan Y, Wang L, Lin Y, Bo T, Zhang J, Wang T, Xin W, Yu C, Guan Q, Zhou X, Gao L, Xu C, Zhao J.

J Hepatol. 2014 Dec;61(6):1358-64. doi: 10.1016/j.jhep.2014.06.037. Epub 2014 Jul 10.


Ginsenoside Compound K suppresses the hepatic gluconeogenesis via activating adenosine-5'monophosphate kinase: A study in vitro and in vivo.

Wei S, Li W, Yu Y, Yao F, A L, Lan X, Guan F, Zhang M, Chen L.

Life Sci. 2015 Oct 15;139:8-15. doi: 10.1016/j.lfs.2015.07.032. Epub 2015 Aug 15.


A novel role for thyroid-stimulating hormone: up-regulation of hepatic 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase expression through the cyclic adenosine monophosphate/protein kinase A/cyclic adenosine monophosphate-responsive element binding protein pathway.

Tian L, Song Y, Xing M, Zhang W, Ning G, Li X, Yu C, Qin C, Liu J, Tian X, Sun X, Fu R, Zhang L, Zhang X, Lu Y, Zou J, Wang L, Guan Q, Gao L, Zhao J.

Hepatology. 2010 Oct;52(4):1401-9. doi: 10.1002/hep.23800.


Effects of resistin expression on glucose metabolism and hepatic insulin resistance.

Li FP, He J, Li ZZ, Luo ZF, Yan L, Li Y.

Endocrine. 2009 Apr;35(2):243-51. doi: 10.1007/s12020-009-9148-4. Epub 2009 Jan 31.


Berberine inhibits hepatic gluconeogenesis via the LKB1-AMPK-TORC2 signaling pathway in streptozotocin-induced diabetic rats.

Jiang SJ, Dong H, Li JB, Xu LJ, Zou X, Wang KF, Lu FE, Yi P.

World J Gastroenterol. 2015 Jul 7;21(25):7777-85. doi: 10.3748/wjg.v21.i25.7777.


AMPK-dependent repression of hepatic gluconeogenesis via disruption of CREB.CRTC2 complex by orphan nuclear receptor small heterodimer partner.

Lee JM, Seo WY, Song KH, Chanda D, Kim YD, Kim DK, Lee MW, Ryu D, Kim YH, Noh JR, Lee CH, Chiang JY, Koo SH, Choi HS.

J Biol Chem. 2010 Oct 15;285(42):32182-91. doi: 10.1074/jbc.M110.134890. Epub 2010 Aug 5.


Extracellular visfatin activates gluconeogenesis in HepG2 cells through the classical PKA/CREB-dependent pathway.

Choi YJ, Choi SE, Ha ES, Kang Y, Han SJ, Kim DJ, Lee KW, Kim HJ.

Horm Metab Res. 2014 Apr;46(4):233-9. doi: 10.1055/s-0034-1370907. Epub 2014 Mar 13.


Intestinal gluconeogenesis is crucial to maintain a physiological fasting glycemia in the absence of hepatic glucose production in mice.

Penhoat A, Fayard L, Stefanutti A, Mithieux G, Rajas F.

Metabolism. 2014 Jan;63(1):104-11. doi: 10.1016/j.metabol.2013.09.005. Epub 2013 Oct 14.


Orphan nuclear receptor small heterodimer partner negatively regulates growth hormone-mediated induction of hepatic gluconeogenesis through inhibition of signal transducer and activator of transcription 5 (STAT5) transactivation.

Kim YD, Li T, Ahn SW, Kim DK, Lee JM, Hwang SL, Kim YH, Lee CH, Lee IK, Chiang JY, Choi HS.

J Biol Chem. 2012 Oct 26;287(44):37098-108. doi: 10.1074/jbc.M112.339887. Epub 2012 Sep 12.


Irisin inhibits hepatic gluconeogenesis and increases glycogen synthesis via the PI3K/Akt pathway in type 2 diabetic mice and hepatocytes.

Liu TY, Shi CX, Gao R, Sun HJ, Xiong XQ, Ding L, Chen Q, Li YH, Wang JJ, Kang YM, Zhu GQ.

Clin Sci (Lond). 2015 Nov;129(10):839-50. doi: 10.1042/CS20150009. Epub 2015 Jul 13.


CREB regulates hepatic gluconeogenesis through the coactivator PGC-1.

Herzig S, Long F, Jhala US, Hedrick S, Quinn R, Bauer A, Rudolph D, Schutz G, Yoon C, Puigserver P, Spiegelman B, Montminy M.

Nature. 2001 Sep 13;413(6852):179-83. Erratum in: Nature 2001 Oct 11;413(6856):652.


AMP-activated protein kinase activation increases phosphorylation of glycogen synthase kinase 3beta and thereby reduces cAMP-responsive element transcriptional activity and phosphoenolpyruvate carboxykinase C gene expression in the liver.

Horike N, Sakoda H, Kushiyama A, Ono H, Fujishiro M, Kamata H, Nishiyama K, Uchijima Y, Kurihara Y, Kurihara H, Asano T.

J Biol Chem. 2008 Dec 5;283(49):33902-10. doi: 10.1074/jbc.M802537200. Epub 2008 Sep 17.


B-cell translocation gene-2 increases hepatic gluconeogenesis via induction of CREB.

Hwang SL, Kwon O, Lee SJ, Roh SS, Kim YD, Choi JH.

Biochem Biophys Res Commun. 2012 Nov 2;427(4):801-5. doi: 10.1016/j.bbrc.2012.09.146. Epub 2012 Oct 9.


Mechanisms by which liver-specific PEPCK knockout mice preserve euglycemia during starvation.

She P, Burgess SC, Shiota M, Flakoll P, Donahue EP, Malloy CR, Sherry AD, Magnuson MA.

Diabetes. 2003 Jul;52(7):1649-54.


Hepatic protein phosphatase 1 regulatory subunit 3B (Ppp1r3b) promotes hepatic glycogen synthesis and thereby regulates fasting energy homeostasis.

Mehta MB, Shewale SV, Sequeira RN, Millar JS, Hand NJ, Rader DJ.

J Biol Chem. 2017 Jun 23;292(25):10444-10454. doi: 10.1074/jbc.M116.766329. Epub 2017 May 4.


FGF21 maintains glucose homeostasis by mediating the cross talk between liver and brain during prolonged fasting.

Liang Q, Zhong L, Zhang J, Wang Y, Bornstein SR, Triggle CR, Ding H, Lam KS, Xu A.

Diabetes. 2014 Dec;63(12):4064-75. doi: 10.2337/db14-0541. Epub 2014 Jul 14.


Role of PGC-1α in exercise and fasting-induced adaptations in mouse liver.

Haase TN, Ringholm S, Leick L, Biensø RS, Kiilerich K, Johansen S, Nielsen MM, Wojtaszewski JF, Hidalgo J, Pedersen PA, Pilegaard H.

Am J Physiol Regul Integr Comp Physiol. 2011 Nov;301(5):R1501-9. doi: 10.1152/ajpregu.00775.2010. Epub 2011 Aug 10.


Gluconeogenic signals regulate iron homeostasis via hepcidin in mice.

Vecchi C, Montosi G, Garuti C, Corradini E, Sabelli M, Canali S, Pietrangelo A.

Gastroenterology. 2014 Apr;146(4):1060-9. doi: 10.1053/j.gastro.2013.12.016. Epub 2013 Dec 17.


Endoplasmic reticulum stress-induced activation of activating transcription factor 6 decreases cAMP-stimulated hepatic gluconeogenesis via inhibition of CREB.

Seo HY, Kim MK, Min AK, Kim HS, Ryu SY, Kim NK, Lee KM, Kim HJ, Choi HS, Lee KU, Park KG, Lee IK.

Endocrinology. 2010 Feb;151(2):561-8. doi: 10.1210/en.2009-0641. Epub 2009 Dec 18.


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