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Items: 1 to 20 of 139

1.

Structure of parkin reveals mechanisms for ubiquitin ligase activation.

Trempe JF, Sauvé V, Grenier K, Seirafi M, Tang MY, Ménade M, Al-Abdul-Wahid S, Krett J, Wong K, Kozlov G, Nagar B, Fon EA, Gehring K.

Science. 2013 Jun 21;340(6139):1451-5. doi: 10.1126/science.1237908. Epub 2013 May 9.

2.

Identification of a novel Zn2+-binding domain in the autosomal recessive juvenile Parkinson-related E3 ligase parkin.

Hristova VA, Beasley SA, Rylett RJ, Shaw GS.

J Biol Chem. 2009 May 29;284(22):14978-86. doi: 10.1074/jbc.M808700200. Epub 2009 Apr 1.

3.

Structure of the human Parkin ligase domain in an autoinhibited state.

Wauer T, Komander D.

EMBO J. 2013 Jul 31;32(15):2099-112. doi: 10.1038/emboj.2013.125. Epub 2013 May 31.

4.
5.

A comprehensive computational study on pathogenic mis-sense mutations spanning the RING2 and REP domains of Parkin protein.

Biswas R, Bagchi A.

Gene. 2017 Apr 30;610:49-58. doi: 10.1016/j.gene.2017.02.008. Epub 2017 Feb 9.

PMID:
28189762
6.

A molecular explanation for the recessive nature of parkin-linked Parkinson's disease.

Spratt DE, Martinez-Torres RJ, Noh YJ, Mercier P, Manczyk N, Barber KR, Aguirre JD, Burchell L, Purkiss A, Walden H, Shaw GS.

Nat Commun. 2013;4:1983. doi: 10.1038/ncomms2983.

7.

Isolated RING2 domain of parkin is sufficient for E2-dependent E3 ligase activity.

Rankin CA, Galeva NA, Bae K, Ahmad MN, Witte TM, Richter ML.

Biochemistry. 2014 Jan 14;53(1):225-34. doi: 10.1021/bi401378p. Epub 2013 Dec 24.

PMID:
24328108
8.

Mechanism of phospho-ubiquitin-induced PARKIN activation.

Wauer T, Simicek M, Schubert A, Komander D.

Nature. 2015 Aug 20;524(7565):370-4. doi: 10.1038/nature14879. Epub 2015 Jul 10. Erratum in: Nature. 2015 Oct 29;526(7575):728.

9.

Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis.

Kumar A, Aguirre JD, Condos TE, Martinez-Torres RJ, Chaugule VK, Toth R, Sundaramoorthy R, Mercier P, Knebel A, Spratt DE, Barber KR, Shaw GS, Walden H.

EMBO J. 2015 Oct 14;34(20):2506-21. doi: 10.15252/embj.201592337. Epub 2015 Aug 7.

10.

Parkin-phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity.

Kumar A, Chaugule VK, Condos TEC, Barber KR, Johnson C, Toth R, Sundaramoorthy R, Knebel A, Shaw GS, Walden H.

Nat Struct Mol Biol. 2017 May;24(5):475-483. doi: 10.1038/nsmb.3400. Epub 2017 Apr 17.

PMID:
28414322
11.

Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases.

Riley BE, Lougheed JC, Callaway K, Velasquez M, Brecht E, Nguyen L, Shaler T, Walker D, Yang Y, Regnstrom K, Diep L, Zhang Z, Chiou S, Bova M, Artis DR, Yao N, Baker J, Yednock T, Johnston JA.

Nat Commun. 2013;4:1982. doi: 10.1038/ncomms2982.

12.
13.

A Ubl/ubiquitin switch in the activation of Parkin.

Sauvé V, Lilov A, Seirafi M, Vranas M, Rasool S, Kozlov G, Sprules T, Wang J, Trempe JF, Gehring K.

EMBO J. 2015 Oct 14;34(20):2492-505. doi: 10.15252/embj.201592237. Epub 2015 Aug 7.

14.

Autoregulation of Parkin activity through its ubiquitin-like domain.

Chaugule VK, Burchell L, Barber KR, Sidhu A, Leslie SJ, Shaw GS, Walden H.

EMBO J. 2011 Jun 21;30(14):2853-67. doi: 10.1038/emboj.2011.204.

15.

Phosphorylation by PINK1 releases the UBL domain and initializes the conformational opening of the E3 ubiquitin ligase Parkin.

Caulfield TR, Fiesel FC, Moussaud-Lamodière EL, Dourado DF, Flores SC, Springer W.

PLoS Comput Biol. 2014 Nov 6;10(11):e1003935. doi: 10.1371/journal.pcbi.1003935. eCollection 2014 Nov.

16.

Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity.

Kazlauskaite A, Kelly V, Johnson C, Baillie C, Hastie CJ, Peggie M, Macartney T, Woodroof HI, Alessi DR, Pedrioli PG, Muqit MM.

Open Biol. 2014 Mar 19;4:130213. doi: 10.1098/rsob.130213.

17.

A disease state mutation unfolds the parkin ubiquitin-like domain.

Safadi SS, Shaw GS.

Biochemistry. 2007 Dec 11;46(49):14162-9. Epub 2007 Nov 16.

PMID:
18004887
18.

Interaction between RING1 (R1) and the Ubiquitin-like (UBL) Domains Is Critical for the Regulation of Parkin Activity.

Ham SJ, Lee SY, Song S, Chung JR, Choi S, Chung J.

J Biol Chem. 2016 Jan 22;291(4):1803-16. doi: 10.1074/jbc.M115.687319. Epub 2015 Dec 2.

19.

Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity.

Yao D, Gu Z, Nakamura T, Shi ZQ, Ma Y, Gaston B, Palmer LA, Rockenstein EM, Zhang Z, Masliah E, Uehara T, Lipton SA.

Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10810-4. Epub 2004 Jul 13. Erratum in: Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13969.

20.

Compact Parkin only: insights into the structure of an autoinhibited ubiquitin ligase.

Byrd RA, Weissman AM.

EMBO J. 2013 Jul 31;32(15):2087-9. doi: 10.1038/emboj.2013.158. Epub 2013 Jul 12. Review.

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