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Items: 1 to 20 of 100

1.

Integrative toxicoproteomics implicates impaired mitochondrial glutathione import as an off-target effect of troglitazone.

Lee YH, Goh WW, Ng CK, Raida M, Wong L, Lin Q, Boelsterli UA, Chung MC.

J Proteome Res. 2013 Jun 7;12(6):2933-45. doi: 10.1021/pr400219s. Epub 2013 May 28.

2.

Troglitazone-induced hepatic necrosis in an animal model of silent genetic mitochondrial abnormalities.

Ong MM, Latchoumycandane C, Boelsterli UA.

Toxicol Sci. 2007 May;97(1):205-13. Epub 2006 Dec 5.

PMID:
17150972
3.
4.

Troglitazone-induced hepatic mitochondrial proteome expression dynamics in heterozygous Sod2(+/-) mice: two-stage oxidative injury.

Lee YH, Chung MC, Lin Q, Boelsterli UA.

Toxicol Appl Pharmacol. 2008 Aug 15;231(1):43-51. doi: 10.1016/j.taap.2008.03.025. Epub 2008 Apr 12.

PMID:
18495193
5.

Troglitazone hepatotoxicity: are we getting closer to understanding idiosyncratic liver injury?

Jaeschke H.

Toxicol Sci. 2007 May;97(1):1-3. No abstract available.

PMID:
17575588
7.

Characterizing the mechanism of thiazolidinedione-induced hepatotoxicity: An in vitro model in mitochondria.

Hu D, Wu CQ, Li ZJ, Liu Y, Fan X, Wang QJ, Ding RG.

Toxicol Appl Pharmacol. 2015 Apr 15;284(2):134-41. doi: 10.1016/j.taap.2015.02.018. Epub 2015 Feb 27.

PMID:
25727309
8.

Studies on the metabolism of troglitazone to reactive intermediates in vitro and in vivo. Evidence for novel biotransformation pathways involving quinone methide formation and thiazolidinedione ring scission.

Kassahun K, Pearson PG, Tang W, McIntosh I, Leung K, Elmore C, Dean D, Wang R, Doss G, Baillie TA.

Chem Res Toxicol. 2001 Jan;14(1):62-70.

PMID:
11170509
9.

Multiple mechanisms underlying troglitazone-induced mitochondrial permeability transition.

Okuda T, Norioka M, Shitara Y, Horie T.

Toxicol Appl Pharmacol. 2010 Nov 1;248(3):242-8. doi: 10.1016/j.taap.2010.08.007. Epub 2010 Aug 12.

PMID:
20709092
11.

Troglitazone induces cytotoxicity in part by promoting the degradation of peroxisome proliferator-activated receptor γ co-activator-1α protein.

Liao X, Wang Y, Wong CW.

Br J Pharmacol. 2010 Oct;161(4):771-81. doi: 10.1111/j.1476-5381.2010.00900.x.

12.

Mitochondrial permeability transition as a potential determinant of hepatotoxicity of antidiabetic thiazolidinediones.

Masubuchi Y, Kano S, Horie T.

Toxicology. 2006 May 15;222(3):233-9. Epub 2006 Apr 18.

PMID:
16621215
13.

Sensitivity of liver injury in heterozygous Sod2 knockout mice treated with troglitazone or acetaminophen.

Fujimoto K, Kumagai K, Ito K, Arakawa S, Ando Y, Oda S, Yamoto T, Manabe S.

Toxicol Pathol. 2009 Feb;37(2):193-200. doi: 10.1177/0192623308329282.

PMID:
19332662
14.

Species-specific toxicity of troglitazone on rats and human by gel entrapped hepatocytes.

Shen C, Meng Q, Zhang G.

Toxicol Appl Pharmacol. 2012 Jan 1;258(1):19-25. doi: 10.1016/j.taap.2011.10.020. Epub 2011 Nov 6.

PMID:
22085495
15.

Direct toxicity effects of sulfo-conjugated troglitazone on human hepatocytes.

Saha S, New LS, Ho HK, Chui WK, Chan EC.

Toxicol Lett. 2010 Jun 2;195(2-3):135-41. doi: 10.1016/j.toxlet.2010.03.010. Epub 2010 Mar 20.

PMID:
20307632
16.

Role of mitogen-activated protein kinase (MAPK) in troglitazone-induced osteoblastic cell death.

Jung JY, Yoo CI, Kim HT, Kwon CH, Park JY, Kim YK.

Toxicology. 2007 May 5;234(1-2):73-82. Epub 2007 Feb 20.

PMID:
17363128
17.

Investigation of the role of the thiazolidinedione ring of troglitazone in inducing hepatotoxicity.

Saha S, New LS, Ho HK, Chui WK, Chan EC.

Toxicol Lett. 2010 Feb 1;192(2):141-9. doi: 10.1016/j.toxlet.2009.10.014. Epub 2009 Oct 23.

PMID:
19854250
18.

Involvement of organic anion transporting polypeptides in the transport of troglitazone sulfate: implications for understanding troglitazone hepatotoxicity.

Nozawa T, Sugiura S, Nakajima M, Goto A, Yokoi T, Nezu J, Tsuji A, Tamai I.

Drug Metab Dispos. 2004 Mar;32(3):291-4.

19.

The impact of partial manganese superoxide dismutase (SOD2)-deficiency on mitochondrial oxidant stress, DNA fragmentation and liver injury during acetaminophen hepatotoxicity.

Ramachandran A, Lebofsky M, Weinman SA, Jaeschke H.

Toxicol Appl Pharmacol. 2011 Mar 15;251(3):226-33. doi: 10.1016/j.taap.2011.01.004. Epub 2011 Jan 15.

20.

Chimeric mice with a humanized liver as an animal model of troglitazone-induced liver injury.

Kakuni M, Morita M, Matsuo K, Katoh Y, Nakajima M, Tateno C, Yokoi T.

Toxicol Lett. 2012 Oct 2;214(1):9-18. doi: 10.1016/j.toxlet.2012.08.001. Epub 2012 Aug 10.

PMID:
22902350

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