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Items: 1 to 20 of 90

1.

Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction.

Manka J, Daniels RN, Dawson E, Daniels JS, Southall N, Jadhav A, Zheng W, Austin C, Grembecka J, Cierpicki T, Lindsley CW, Stauffer SR.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2011 Mar 31 [updated 2013 Feb 28].

2.

Progress towards small molecule inhibitors of the Menin-Mixed Lineage Leukemia (MLL) interaction with in vivo utility.

Senter T, Gogliotti R, Han C, Locuson CW II, Morrison R, Daniels JS, Cierpicki T, Grembecka J, Lindsley CW, Stauffer SR.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2013 Apr 15 [updated 2015 Feb 11].

3.

Molecular basis of the mixed lineage leukemia-menin interaction: implications for targeting mixed lineage leukemias.

Grembecka J, Belcher AM, Hartley T, Cierpicki T.

J Biol Chem. 2010 Dec 24;285(52):40690-8. doi: 10.1074/jbc.M110.172783. Epub 2010 Oct 20.

4.

High-affinity small-molecule inhibitors of the menin-mixed lineage leukemia (MLL) interaction closely mimic a natural protein-protein interaction.

He S, Senter TJ, Pollock J, Han C, Upadhyay SK, Purohit T, Gogliotti RD, Lindsley CW, Cierpicki T, Stauffer SR, Grembecka J.

J Med Chem. 2014 Feb 27;57(4):1543-56. doi: 10.1021/jm401868d. Epub 2014 Feb 6.

5.

Identification of novel small-molecule inhibitors targeting menin-MLL interaction, repurposing the antidiarrheal loperamide.

Yue L, Du J, Ye F, Chen Z, Li L, Lian F, Zhang B, Zhang Y, Jiang H, Chen K, Li Y, Zhou B, Zhang N, Yang Y, Luo C.

Org Biomol Chem. 2016 Sep 28;14(36):8503-19. doi: 10.1039/c6ob01248e. Epub 2016 Aug 19.

PMID:
27541268
6.

Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia.

Shi A, Murai MJ, He S, Lund G, Hartley T, Purohit T, Reddy G, Chruszcz M, Grembecka J, Cierpicki T.

Blood. 2012 Nov 29;120(23):4461-9. doi: 10.1182/blood-2012-05-429274. Epub 2012 Aug 30.

7.

Crystal structure of menin reveals binding site for mixed lineage leukemia (MLL) protein.

Murai MJ, Chruszcz M, Reddy G, Grembecka J, Cierpicki T.

J Biol Chem. 2011 Sep 9;286(36):31742-8. doi: 10.1074/jbc.M111.258186. Epub 2011 Jul 13.

8.

Progress towards small molecule menin-mixed lineage leukemia (MLL) interaction inhibitors with in vivo utility.

Senter T, Gogliotti RD, Han C, Locuson CW, Morrison R, Daniels JS, Cierpicki T, Grembecka J, Lindsley CW, Stauffer SR.

Bioorg Med Chem Lett. 2015 Jul 1;25(13):2720-5. doi: 10.1016/j.bmcl.2015.04.026. Epub 2015 Apr 25.

PMID:
25987377
9.

Design and synthesis of benzylpiperidine inhibitors targeting the menin-MLL1 interface.

Ren J, Xu W, Tang L, Su M, Chen D, Chen YL, Zang Y, Li J, Shen J, Zhou Y, Xiong B.

Bioorg Med Chem Lett. 2016 Sep 15;26(18):4472-6. doi: 10.1016/j.bmcl.2016.07.074. Epub 2016 Aug 2.

PMID:
27528435
10.

Discovery of two aminoglycoside antibiotics as inhibitors targeting the menin-mixed lineage leukaemia interface.

Li L, Zhou R, Geng H, Yue L, Ye F, Xie Y, Liu J, Kong X, Jiang H, Huang J, Luo C.

Bioorg Med Chem Lett. 2014 May 1;24(9):2090-3. doi: 10.1016/j.bmcl.2014.03.055. Epub 2014 Mar 26.

PMID:
24709560
11.

Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia.

Grembecka J, He S, Shi A, Purohit T, Muntean AG, Sorenson RJ, Showalter HD, Murai MJ, Belcher AM, Hartley T, Hess JL, Cierpicki T.

Nat Chem Biol. 2012 Jan 29;8(3):277-84. doi: 10.1038/nchembio.773.

12.

Pharmacologic inhibition of the Menin-MLL interaction blocks progression of MLL leukemia in vivo.

Borkin D, He S, Miao H, Kempinska K, Pollock J, Chase J, Purohit T, Malik B, Zhao T, Wang J, Wen B, Zong H, Jones M, Danet-Desnoyers G, Guzman ML, Talpaz M, Bixby DL, Sun D, Hess JL, Muntean AG, Maillard I, Cierpicki T, Grembecka J.

Cancer Cell. 2015 Apr 13;27(4):589-602. doi: 10.1016/j.ccell.2015.02.016. Epub 2015 Mar 26.

13.

[Interaction between mixed-lineage leukemia and Menin proteins].

Liu L, Li BS, Ye QD, He YY, Tang JY.

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2009 Oct;17(5):1130-4. Chinese.

PMID:
19840436
14.

Challenges and opportunities in targeting the menin-MLL interaction.

Cierpicki T, Grembecka J.

Future Med Chem. 2014 Mar;6(4):447-62. doi: 10.4155/fmc.13.214. Review.

15.

Discovery of Novel Inhibitors Targeting the Menin-Mixed Lineage Leukemia Interface Using Pharmacophore- and Docking-Based Virtual Screening.

Xu Y, Yue L, Wang Y, Xing J, Chen Z, Shi Z, Liu R, Liu YC, Luo X, Jiang H, Chen K, Luo C, Zheng M.

J Chem Inf Model. 2016 Sep 26;56(9):1847-55. doi: 10.1021/acs.jcim.6b00185. Epub 2016 Aug 24.

PMID:
27513308
16.

Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL).

Borkin D, Pollock J, Kempinska K, Purohit T, Li X, Wen B, Zhao T, Miao H, Shukla S, He M, Sun D, Cierpicki T, Grembecka J.

J Med Chem. 2016 Feb 11;59(3):892-913. doi: 10.1021/acs.jmedchem.5b01305. Epub 2016 Jan 25.

17.

Menin expression is regulated by transforming growth factor beta signaling in leukemia cells.

Zhang H, Liu ZG, Hua XX.

Chin Med J (Engl). 2011 May;124(10):1556-62.

PMID:
21740816
18.

The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis.

Yokoyama A, Somervaille TC, Smith KS, Rozenblatt-Rosen O, Meyerson M, Cleary ML.

Cell. 2005 Oct 21;123(2):207-18.

19.

Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression.

Yokoyama A, Wang Z, Wysocka J, Sanyal M, Aufiero DJ, Kitabayashi I, Herr W, Cleary ML.

Mol Cell Biol. 2004 Jul;24(13):5639-49.

20.

Interaction of MLL amino terminal sequences with menin is required for transformation.

Caslini C, Yang Z, El-Osta M, Milne TA, Slany RK, Hess JL.

Cancer Res. 2007 Aug 1;67(15):7275-83.

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