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Items: 1 to 20 of 103

1.

Designed biosynthesis of 36-methyl-FK506 by polyketide precursor pathway engineering.

Lechner A, Wilson MC, Ban YH, Hwang JY, Yoon YJ, Moore BS.

ACS Synth Biol. 2013 Jul 19;2(7):379-83. doi: 10.1021/sb3001062. Epub 2012 Nov 5.

3.

Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues.

Mo S, Kim DH, Lee JH, Park JW, Basnet DB, Ban YH, Yoo YJ, Chen SW, Park SR, Choi EA, Kim E, Jin YY, Lee SK, Park JY, Liu Y, Lee MO, Lee KS, Kim SJ, Kim D, Park BC, Lee SG, Kwon HJ, Suh JW, Moore BS, Lim SK, Yoon YJ.

J Am Chem Soc. 2011 Feb 2;133(4):976-85. doi: 10.1021/ja108399b. Epub 2010 Dec 22.

4.

The biosynthetic gene cluster for the macrolactone ring of the immunosuppressant FK506.

Motamedi H, Shafiee A.

Eur J Biochem. 1998 Sep 15;256(3):528-34.

5.
6.

Origin of the allyl group in FK506 biosynthesis.

Goranovic D, Kosec G, Mrak P, Fujs S, Horvat J, Kuscer E, Kopitar G, Petkovic H.

J Biol Chem. 2010 May 7;285(19):14292-300. doi: 10.1074/jbc.M109.059600. Epub 2010 Mar 1.

7.

Metabolic engineering of Streptomyces venezuelae for malonyl-CoA biosynthesis to enhance heterologous production of polyketides.

Maharjan S, Park JW, Yoon YJ, Lee HC, Sohng JK.

Biotechnol Lett. 2010 Feb;32(2):277-82. doi: 10.1007/s10529-009-0152-9. Epub 2009 Oct 17.

PMID:
19838628
8.

Roles of the crotonyl-CoA carboxylase/reductase homologues in acetate assimilation and biosynthesis of immunosuppressant FK506 in Streptomyces tsukubaensis.

Blažič M, Kosec G, Baebler Š, Gruden K, Petković H.

Microb Cell Fact. 2015 Oct 14;14:164. doi: 10.1186/s12934-015-0352-z.

9.
10.
11.

Roles of fkbN in positive regulation and tcs7 in negative regulation of FK506 biosynthesis in Streptomyces sp. strain KCTC 11604BP.

Mo S, Yoo YJ, Ban YH, Lee SK, Kim E, Suh JW, Yoon YJ.

Appl Environ Microbiol. 2012 Apr;78(7):2249-55. doi: 10.1128/AEM.06766-11. Epub 2012 Jan 20.

12.

Enhanced FK506 production in Streptomyces clavuligerus CKD1119 by engineering the supply of methylmalonyl-CoA precursor.

Mo S, Ban YH, Park JW, Yoo YJ, Yoon YJ.

J Ind Microbiol Biotechnol. 2009 Dec;36(12):1473-82. doi: 10.1007/s10295-009-0635-7. Epub 2009 Sep 12.

PMID:
19756799
13.
14.

Engineered biosynthesis of a complete macrolactone in a heterologous host.

Kao CM, Katz L, Khosla C.

Science. 1994 Jul 22;265(5171):509-12.

PMID:
8036492
15.
16.

Metabolic engineering of a methylmalonyl-CoA mutase-epimerase pathway for complex polyketide biosynthesis in Escherichia coli.

Dayem LC, Carney JR, Santi DV, Pfeifer BA, Khosla C, Kealey JT.

Biochemistry. 2002 Apr 23;41(16):5193-201.

PMID:
11955068
17.

A new substrate specificity for acyl transferase domains of the ascomycin polyketide synthase in Streptomyces hygroscopicus.

Reeves CD, Chung LM, Liu Y, Xue Q, Carney JR, Revill WP, Katz L.

J Biol Chem. 2002 Mar 15;277(11):9155-9. Epub 2002 Jan 10.

18.

Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.

Kantola J, Blanco G, Hautala A, Kunnari T, Hakala J, Mendez C, Ylihonko K, Mäntsälä P, Salas J.

Chem Biol. 1997 Oct;4(10):751-5.

PMID:
9375253
19.

Developing tools for engineering hybrid polyketide synthetic pathways.

Kittendorf JD, Sherman DH.

Curr Opin Biotechnol. 2006 Dec;17(6):597-605. Epub 2006 Oct 12. Review.

PMID:
17046237
20.

Mutational biosynthesis of tacrolimus analogues by fkbO deletion mutant of Streptomyces sp. KCTC 11604BP.

Kim DH, Ryu JH, Lee KS, Lee BM, Lee MO, Lim SK, Maeng PJ.

Appl Microbiol Biotechnol. 2013 Jul;97(13):5881-92. doi: 10.1007/s00253-013-4716-1. Epub 2013 Feb 8.

PMID:
23392766

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