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Items: 1 to 20 of 105

1.

GANP regulates recruitment of AID to immunoglobulin variable regions by modulating transcription and nucleosome occupancy.

Singh SK, Maeda K, Eid MM, Almofty SA, Ono M, Pham P, Goodman MF, Sakaguchi N.

Nat Commun. 2013;4:1830. doi: 10.1038/ncomms2823.

2.

GANP-mediated recruitment of activation-induced cytidine deaminase to cell nuclei and to immunoglobulin variable region DNA.

Maeda K, Singh SK, Eda K, Kitabatake M, Pham P, Goodman MF, Sakaguchi N.

J Biol Chem. 2010 Jul 30;285(31):23945-53. doi: 10.1074/jbc.M110.131441. Epub 2010 May 27.

3.

GANP regulates the choice of DNA repair pathway by DNA-PKcs interaction in AID-dependent IgV region diversification.

Eid MM, Maeda K, Almofty SA, Singh SK, Shimoda M, Sakaguchi N.

J Immunol. 2014 Jun 15;192(12):5529-39. doi: 10.4049/jimmunol.1400021. Epub 2014 May 7.

4.

Germinal Center B-Cell-Associated Nuclear Protein (GANP) Involved in RNA Metabolism for B Cell Maturation.

Sakaguchi N, Maeda K.

Adv Immunol. 2016;131:135-86. doi: 10.1016/bs.ai.2016.02.003. Epub 2016 Mar 29. Review.

PMID:
27235683
5.

Molecular mechanism of immunoglobulin V-region diversification regulated by transcription and RNA metabolism in antigen-driven B cells.

Sakaguchi N, Maeda K, Kuwahara K.

Scand J Immunol. 2011 Jun;73(6):520-6. doi: 10.1111/j.1365-3083.2011.02557.x. Review.

6.

AID-targeting and hypermutation of non-immunoglobulin genes does not correlate with proximity to immunoglobulin genes in germinal center B cells.

Gramlich HS, Reisbig T, Schatz DG.

PLoS One. 2012;7(6):e39601. doi: 10.1371/journal.pone.0039601. Epub 2012 Jun 29.

7.

Spt5 accumulation at variable genes distinguishes somatic hypermutation in germinal center B cells from ex vivo-activated cells.

Maul RW, Cao Z, Venkataraman L, Giorgetti CA, Press JL, Denizot Y, Du H, Sen R, Gearhart PJ.

J Exp Med. 2014 Oct 20;211(11):2297-306. doi: 10.1084/jem.20131512. Epub 2014 Oct 6.

8.

Germinal center-associated nuclear protein (GANP) has a phosphorylation-dependent DNA-primase activity that is up-regulated in germinal center regions.

Kuwahara K, Tomiyasu S, Fujimura S, Nomura K, Xing Y, Nishiyama N, Ogawa M, Imajoh-Ohmi S, Izuta S, Sakaguchi N.

Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10279-83.

9.

Cutting edge: double-stranded DNA breaks in the IgV region gene were detected at lower frequency in affinity-maturation impeded GANP-/- mice.

Kawatani Y, Igarashi H, Matsui T, Kuwahara K, Fujimura S, Okamoto N, Takagi K, Sakaguchi N.

J Immunol. 2005 Nov 1;175(9):5615-8.

10.

mRNA export from mammalian cell nuclei is dependent on GANP.

Wickramasinghe VO, McMurtrie PI, Mills AD, Takei Y, Penrhyn-Lowe S, Amagase Y, Main S, Marr J, Stewart M, Laskey RA.

Curr Biol. 2010 Jan 12;20(1):25-31. doi: 10.1016/j.cub.2009.10.078. Epub 2009 Dec 10.

11.

Topoisomerase I deficiency causes RNA polymerase II accumulation and increases AID abundance in immunoglobulin variable genes.

Maul RW, Saribasak H, Cao Z, Gearhart PJ.

DNA Repair (Amst). 2015 Jun;30:46-52. doi: 10.1016/j.dnarep.2015.03.004. Epub 2015 Mar 18.

12.

Replication protein A interacts with AID to promote deamination of somatic hypermutation targets.

Chaudhuri J, Khuong C, Alt FW.

Nature. 2004 Aug 26;430(7003):992-8. Epub 2004 Jul 25.

13.

A combined nuclear and nucleolar localization motif in activation-induced cytidine deaminase (AID) controls immunoglobulin class switching.

Hu Y, Ericsson I, Torseth K, Methot SP, Sundheim O, Liabakk NB, Slupphaug G, Di Noia JM, Krokan HE, Kavli B.

J Mol Biol. 2013 Jan 23;425(2):424-43. doi: 10.1016/j.jmb.2012.11.026. Epub 2012 Nov 23.

PMID:
23183374
14.
15.

Nucleosome stability dramatically impacts the targeting of somatic hypermutation.

Kodgire P, Mukkawar P, North JA, Poirier MG, Storb U.

Mol Cell Biol. 2012 May;32(10):2030-40. doi: 10.1128/MCB.06722-11. Epub 2012 Mar 5.

16.

The histone chaperone Spt6 is required for activation-induced cytidine deaminase target determination through H3K4me3 regulation.

Begum NA, Stanlie A, Nakata M, Akiyama H, Honjo T.

J Biol Chem. 2012 Sep 21;287(39):32415-29. Epub 2012 Jul 26.

17.

The IgH 3' regulatory region controls somatic hypermutation in germinal center B cells.

Rouaud P, Vincent-Fabert C, Saintamand A, Fiancette R, Marquet M, Robert I, Reina-San-Martin B, Pinaud E, Cogné M, Denizot Y.

J Exp Med. 2013 Jul 29;210(8):1501-7. doi: 10.1084/jem.20130072. Epub 2013 Jul 1.

18.

Integrity of immunoglobulin variable regions is supported by GANP during AID-induced somatic hypermutation in germinal center B cells.

Eid MMA, Shimoda M, Singh SK, Almofty SA, Pham P, Goodman MF, Maeda K, Sakaguchi N.

Int Immunol. 2017 May 1;29(5):211-220. doi: 10.1093/intimm/dxx032.

PMID:
28541550
19.

E3-ubiquitin ligase Nedd4 determines the fate of AID-associated RNA polymerase II in B cells.

Sun J, Keim CD, Wang J, Kazadi D, Oliver PM, Rabadan R, Basu U.

Genes Dev. 2013 Aug 15;27(16):1821-33. doi: 10.1101/gad.210211.112.

20.

The activation-induced cytidine deaminase (AID) efficiently targets DNA in nucleosomes but only during transcription.

Shen HM, Poirier MG, Allen MJ, North J, Lal R, Widom J, Storb U.

J Exp Med. 2009 May 11;206(5):1057-71. doi: 10.1084/jem.20082678. Epub 2009 Apr 20.

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