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Items: 1 to 20 of 390

1.

Differential coordination demands in Fe versus Mn water-soluble cationic metalloporphyrins translate into remarkably different aqueous redox chemistry and biology.

Tovmasyan A, Weitner T, Sheng H, Lu M, Rajic Z, Warner DS, Spasojevic I, Reboucas JS, Benov L, Batinic-Haberle I.

Inorg Chem. 2013 May 20;52(10):5677-91. doi: 10.1021/ic3012519. Epub 2013 May 6.

2.

A comprehensive evaluation of catalase-like activity of different classes of redox-active therapeutics.

Tovmasyan A, Maia CG, Weitner T, Carballal S, Sampaio RS, Lieb D, Ghazaryan R, Ivanovic-Burmazovic I, Ferrer-Sueta G, Radi R, Reboucas JS, Spasojevic I, Benov L, Batinic-Haberle I.

Free Radic Biol Med. 2015 Sep;86:308-21. doi: 10.1016/j.freeradbiomed.2015.05.018. Epub 2015 May 28.

3.

Methoxy-derivatization of alkyl chains increases the in vivo efficacy of cationic Mn porphyrins. Synthesis, characterization, SOD-like activity, and SOD-deficient E. coli study of meta Mn(III) N-methoxyalkylpyridylporphyrins.

Tovmasyan AG, Rajic Z, Spasojevic I, Reboucas JS, Chen X, Salvemini D, Sheng H, Warner DS, Benov L, Batinic-Haberle I.

Dalton Trans. 2011 Apr 28;40(16):4111-21. doi: 10.1039/c0dt01321h. Epub 2011 Mar 8.

4.

Rational design of superoxide dismutase (SOD) mimics: the evaluation of the therapeutic potential of new cationic Mn porphyrins with linear and cyclic substituents.

Tovmasyan A, Carballal S, Ghazaryan R, Melikyan L, Weitner T, Maia CG, Reboucas JS, Radi R, Spasojevic I, Benov L, Batinic-Haberle I.

Inorg Chem. 2014 Nov 3;53(21):11467-83. doi: 10.1021/ic501329p. Epub 2014 Oct 21.

5.

SOD-like activity of Mn(II) beta-octabromo-meso-tetrakis(N-methylpyridinium-3-yl)porphyrin equals that of the enzyme itself.

DeFreitas-Silva G, Rebouças JS, Spasojević I, Benov L, Idemori YM, Batinić-Haberle I.

Arch Biochem Biophys. 2008 Sep 1;477(1):105-12. doi: 10.1016/j.abb.2008.04.032. Epub 2008 Apr 30.

6.

New class of potent catalysts of O2.-dismutation. Mn(III) ortho-methoxyethylpyridyl- and di-ortho-methoxyethylimidazolylporphyrins.

Batinić-Haberle I, Spasojević I, Stevens RD, Hambright P, Neta P, Okado-Matsumoto A, Fridovich I.

Dalton Trans. 2004 Jun 7;(11):1696-702. Epub 2004 May 5.

PMID:
15252564
7.

Redox modulation of oxidative stress by Mn porphyrin-based therapeutics: the effect of charge distribution.

Rebouças JS, Spasojević I, Tjahjono DH, Richaud A, Méndez F, Benov L, Batinić-Haberle I.

Dalton Trans. 2008 Mar 7;(9):1233-42. doi: 10.1039/b716517j. Epub 2008 Jan 7.

PMID:
18283384
8.

Impact of electrostatics in redox modulation of oxidative stress by Mn porphyrins: protection of SOD-deficient Escherichia coli via alternative mechanism where Mn porphyrin acts as a Mn carrier.

Rebouças JS, DeFreitas-Silva G, Spasojević I, Idemori YM, Benov L, Batinić-Haberle I.

Free Radic Biol Med. 2008 Jul 15;45(2):201-10. doi: 10.1016/j.freeradbiomed.2008.04.009. Epub 2008 May 5.

9.

A comparative mechanistic study of the reversible binding of NO to a water-soluble octa-cationic Fe(III) porphyrin complex.

Jee JE, Wolak M, Balbinot D, Jux N, Zahl A, van Eldik R.

Inorg Chem. 2006 Feb 6;45(3):1326-37.

PMID:
16441145
10.

Anticancer therapeutic potential of Mn porphyrin/ascorbate system.

Tovmasyan A, Sampaio RS, Boss MK, Bueno-Janice JC, Bader BH, Thomas M, Reboucas JS, Orr M, Chandler JD, Go YM, Jones DP, Venkatraman TN, Haberle S, Kyui N, Lascola CD, Dewhirst MW, Spasojevic I, Benov L, Batinic-Haberle I.

Free Radic Biol Med. 2015 Dec;89:1231-47. doi: 10.1016/j.freeradbiomed.2015.10.416. Epub 2015 Oct 20.

11.

Chemical properties of water-soluble porphyrins. 5. Reactions of some manganese (III) porphyrins with the superoxide and other reducing radicals.

Weinraub D, Levy P, Faraggi M.

Int J Radiat Biol Relat Stud Phys Chem Med. 1986 Oct;50(4):649-58.

PMID:
3019912
12.

An educational overview of the chemistry, biochemistry and therapeutic aspects of Mn porphyrins--From superoxide dismutation to H2O2-driven pathways.

Batinic-Haberle I, Tovmasyan A, Spasojevic I.

Redox Biol. 2015 Aug;5:43-65. doi: 10.1016/j.redox.2015.01.017. Epub 2015 Feb 7. Review. Erratum in: Redox Biol. 2015 Dec;6:656.

13.

Robust rat pulmonary radioprotection by a lipophilic Mn N-alkylpyridylporphyrin, MnTnHex-2-PyP(5+).

Gauter-Fleckenstein B, Reboucas JS, Fleckenstein K, Tovmasyan A, Owzar K, Jiang C, Batinic-Haberle I, Vujaskovic Z.

Redox Biol. 2014 Jan 9;2:400-10. doi: 10.1016/j.redox.2013.12.017. eCollection 2014.

14.

A new SOD mimic, Mn(III) ortho N-butoxyethylpyridylporphyrin, combines superb potency and lipophilicity with low toxicity.

Rajic Z, Tovmasyan A, Spasojevic I, Sheng H, Lu M, Li AM, Gralla EB, Warner DS, Benov L, Batinic-Haberle I.

Free Radic Biol Med. 2012 May 1;52(9):1828-34. doi: 10.1016/j.freeradbiomed.2012.02.006. Epub 2012 Feb 13.

16.

Comprehensive pharmacokinetic studies and oral bioavailability of two Mn porphyrin-based SOD mimics, MnTE-2-PyP5+ and MnTnHex-2-PyP5+.

Weitner T, Kos I, Sheng H, Tovmasyan A, Reboucas JS, Fan P, Warner DS, Vujaskovic Z, Batinic-Haberle I, Spasojevic I.

Free Radic Biol Med. 2013 May;58:73-80. doi: 10.1016/j.freeradbiomed.2013.01.006. Epub 2013 Jan 15.

17.

Diverse functions of cationic Mn(III) N-substituted pyridylporphyrins, recognized as SOD mimics.

Batinic-Haberle I, Rajic Z, Tovmasyan A, Reboucas JS, Ye X, Leong KW, Dewhirst MW, Vujaskovic Z, Benov L, Spasojevic I.

Free Radic Biol Med. 2011 Sep 1;51(5):1035-53. doi: 10.1016/j.freeradbiomed.2011.04.046. Epub 2011 May 6. Review.

18.

A potent superoxide dismutase mimic: manganese beta-octabromo-meso-tetrakis-(N-methylpyridinium-4-yl) porphyrin.

Batinić-Haberle I, Liochev SI, Spasojević I, Fridovich I.

Arch Biochem Biophys. 1997 Jul 15;343(2):225-33.

PMID:
9224734
19.

New PEG-ylated Mn(III) porphyrins approaching catalytic activity of SOD enzyme.

Batinić-Haberle I, Spasojević I, Stevens RD, Bondurant B, Okado-Matsumoto A, Fridovich I, Vujasković Z, Dewhirst MW.

Dalton Trans. 2006 Jan 28;(4):617-24. Epub 2005 Dec 19.

PMID:
16402149
20.

Lipophilicity of potent porphyrin-based antioxidants: comparison of ortho and meta isomers of Mn(III) N-alkylpyridylporphyrins.

Kos I, Rebouças JS, DeFreitas-Silva G, Salvemini D, Vujaskovic Z, Dewhirst MW, Spasojević I, Batinić-Haberle I.

Free Radic Biol Med. 2009 Jul 1;47(1):72-8. doi: 10.1016/j.freeradbiomed.2009.04.002. Epub 2009 Apr 8.

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