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AMPK: a contextual oncogene or tumor suppressor?

Liang J, Mills GB.

Cancer Res. 2013 May 15;73(10):2929-35. doi: 10.1158/0008-5472.CAN-12-3876. Epub 2013 May 3. Review.


The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress.

Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC.

Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3329-35. Epub 2004 Feb 25.


Dysfunctional AMPK activity, signalling through mTOR and survival in response to energetic stress in LKB1-deficient lung cancer.

Carretero J, Medina PP, Blanco R, Smit L, Tang M, Roncador G, Maestre L, Conde E, Lopez-Rios F, Clevers HC, Sanchez-Cespedes M.

Oncogene. 2007 Mar 8;26(11):1616-25. Epub 2006 Sep 4.


LKB1 tumor suppressor regulates AMP kinase/mTOR-independent cell growth and proliferation via the phosphorylation of Yap.

Nguyen HB, Babcock JT, Wells CD, Quilliam LA.

Oncogene. 2013 Aug 29;32(35):4100-9. doi: 10.1038/onc.2012.431. Epub 2012 Oct 1.


Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity.

Hahn-Windgassen A, Nogueira V, Chen CC, Skeen JE, Sonenberg N, Hay N.

J Biol Chem. 2005 Sep 16;280(37):32081-9. Epub 2005 Jul 15.


Phosphatidylinositol ether lipid analogues induce AMP-activated protein kinase-dependent death in LKB1-mutant non small cell lung cancer cells.

Memmott RM, Gills JJ, Hollingshead M, Powers MC, Chen Z, Kemp B, Kozikowski A, Dennis PA.

Cancer Res. 2008 Jan 15;68(2):580-8. doi: 10.1158/0008-5472.CAN-07-3091.


AMP-activated protein kinase and human cancer: cancer metabolism revisited.

Kuhajda FP.

Int J Obes (Lond). 2008 Sep;32 Suppl 4:S36-41. doi: 10.1038/ijo.2008.121. Review.


IGF-1 phosphorylates AMPK-alpha subunit in ATM-dependent and LKB1-independent manner.

Suzuki A, Kusakai G, Kishimoto A, Shimojo Y, Ogura T, Lavin MF, Esumi H.

Biochem Biophys Res Commun. 2004 Nov 19;324(3):986-92.


AMPK/TSC2/mTOR-signaling intermediates are not necessary for LKB1-mediated nuclear retention of PTEN tumor suppressor.

Liu JL, Mao Z, Gallick GE, Yung WK.

Neuro Oncol. 2011 Feb;13(2):184-94. doi: 10.1093/neuonc/noq163. Epub 2010 Dec 1.


Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling.

Baba M, Hong SB, Sharma N, Warren MB, Nickerson ML, Iwamatsu A, Esposito D, Gillette WK, Hopkins RF 3rd, Hartley JL, Furihata M, Oishi S, Zhen W, Burke TR Jr, Linehan WM, Schmidt LS, Zbar B.

Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15552-7. Epub 2006 Oct 6.


The AMP-activated protein kinase (AMPK) and cancer: many faces of a metabolic regulator.

Faubert B, Vincent EE, Poffenberger MC, Jones RG.

Cancer Lett. 2015 Jan 28;356(2 Pt A):165-70. doi: 10.1016/j.canlet.2014.01.018. Epub 2014 Jan 28. Review.


20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol suppresses UV-Induced MMP-1 expression through AMPK-mediated mTOR inhibition as a downstream of the PKA-LKB1 pathway.

Shin DJ, Kim JE, Lim TG, Jeong EH, Park G, Kang NJ, Park JS, Yeom MH, Oh DK, Bode AM, Dong Z, Lee HJ, Lee KW.

J Cell Biochem. 2014 Oct;115(10):1702-11. doi: 10.1002/jcb.24833.


Negative regulation of the LKB1/AMPK pathway by ERK in human acute myeloid leukemia cells.

Kawashima I, Mitsumori T, Nozaki Y, Yamamoto T, Shobu-Sueki Y, Nakajima K, Kirito K.

Exp Hematol. 2015 Jul;43(7):524-33.e1. doi: 10.1016/j.exphem.2015.03.005. Epub 2015 Apr 4.


The LKB1 tumor suppressor negatively regulates mTOR signaling.

Shaw RJ, Bardeesy N, Manning BD, Lopez L, Kosmatka M, DePinho RA, Cantley LC.

Cancer Cell. 2004 Jul;6(1):91-9.


The AMP-activated protein kinase pathway--new players upstream and downstream.

Hardie DG.

J Cell Sci. 2004 Nov 1;117(Pt 23):5479-87. Review.


The tumor suppressor gene TUSC2 (FUS1) sensitizes NSCLC to the AKT inhibitor MK2206 in LKB1-dependent manner.

Meng J, Majidi M, Fang B, Ji L, Bekele BN, Minna JD, Roth JA.

PLoS One. 2013 Oct 17;8(10):e77067. doi: 10.1371/journal.pone.0077067. eCollection 2013.


LKB1 and AMPK family signaling: the intimate link between cell polarity and energy metabolism.

Jansen M, Ten Klooster JP, Offerhaus GJ, Clevers H.

Physiol Rev. 2009 Jul;89(3):777-98. doi: 10.1152/physrev.00026.2008. Review.

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