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Items: 1 to 20 of 88


Lung tumor growth-promoting function of peroxiredoxin 6.

Jo M, Yun HM, Park KR, Hee Park M, Myoung Kim T, Ho Pak J, Jae Lee S, Moon DC, Park CW, Song S, Lee CK, Bae Han S, Tae Hong J.

Free Radic Biol Med. 2013 Aug;61:453-63. doi: 10.1016/j.freeradbiomed.2013.04.032. Epub 2013 May 3.


PRDX6 promotes lung tumor progression via its GPx and iPLA2 activities.

Yun HM, Park KR, Lee HP, Lee DH, Jo M, Shin DH, Yoon DY, Han SB, Hong JT.

Free Radic Biol Med. 2014 Apr;69:367-76. doi: 10.1016/j.freeradbiomed.2014.02.001. Epub 2014 Feb 7.


PRDX6 promotes tumor development via the JAK2/STAT3 pathway in a urethane-induced lung tumor model.

Yun HM, Park KR, Park MH, Kim DH, Jo MR, Kim JY, Kim EC, Yoon DY, Han SB, Hong JT.

Free Radic Biol Med. 2015 Mar;80:136-44. doi: 10.1016/j.freeradbiomed.2014.12.022. Epub 2015 Jan 10.


Anti-cancer effect of snake venom toxin through down regulation of AP-1 mediated PRDX6 expression.

Lee HL, Park MH, Son DJ, Song HS, Kim JH, Ko SC, Song MJ, Lee WH, Yoon JH, Ham YW, Han SB, Hong JT.

Oncotarget. 2015 Sep 8;6(26):22139-51.


Anti-cancer effect of thiacremonone through down regulation of peroxiredoxin 6.

Jo M, Yun HM, Park KR, Park MH, Lee DH, Cho SH, Yoo HS, Lee YM, Jeong HS, Kim Y, Jung JK, Hwang BY, Lee MK, Kim ND, Han SB, Hong JT.

PLoS One. 2014 Mar 11;9(3):e91508. doi: 10.1371/journal.pone.0091508. eCollection 2014.


Phospholipase A2 activity of peroxiredoxin 6 promotes invasion and metastasis of lung cancer cells.

Ho JN, Lee SB, Lee SS, Yoon SH, Kang GY, Hwang SG, Um HD.

Mol Cancer Ther. 2010 Apr;9(4):825-32. doi: 10.1158/1535-7163.MCT-09-0904. Epub 2010 Mar 30.


Loss of presenilin 2 is associated with increased iPLA2 activity and lung tumor development.

Yun HM, Park MH, Kim DH, Ahn YJ, Park KR, Kim TM, Yun NY, Jung YS, Hwang DY, Yoon DY, Han SB, Hong JT.

Oncogene. 2014 Oct 30;33(44):5193-200. doi: 10.1038/onc.2014.128. Epub 2014 May 26.


PRDX6 Exacerbates Dopaminergic Neurodegeneration in a MPTP Mouse Model of Parkinson's Disease.

Yun HM, Choi DY, Oh KW, Hong JT.

Mol Neurobiol. 2015 Aug;52(1):422-31. doi: 10.1007/s12035-014-8885-4. Epub 2014 Sep 6.


ZAK inhibits human lung cancer cell growth via ERK and JNK activation in an AP-1-dependent manner.

Yang JJ, Lee YJ, Hung HH, Tseng WP, Tu CC, Lee H, Wu WJ.

Cancer Sci. 2010 Jun;101(6):1374-81. doi: 10.1111/j.1349-7006.2010.01537.x. Epub 2010 Feb 18.


Peroxiredoxin 6 phosphorylation and subsequent phospholipase A2 activity are required for agonist-mediated activation of NADPH oxidase in mouse pulmonary microvascular endothelium and alveolar macrophages.

Chatterjee S, Feinstein SI, Dodia C, Sorokina E, Lien YC, Nguyen S, Debolt K, Speicher D, Fisher AB.

J Biol Chem. 2011 Apr 1;286(13):11696-706. doi: 10.1074/jbc.M110.206623. Epub 2011 Jan 24.


The roles of peroxidase and phospholipase A2 activities of peroxiredoxin 6 in protecting pulmonary microvascular endothelial cells against peroxidative stress.

Lien YC, Feinstein SI, Dodia C, Fisher AB.

Antioxid Redox Signal. 2012 Mar 1;16(5):440-51. doi: 10.1089/ars.2011.3950. Epub 2011 Dec 23.


Peroxiredoxin 6, a 1-Cys peroxiredoxin, functions in antioxidant defense and lung phospholipid metabolism.

Manevich Y, Fisher AB.

Free Radic Biol Med. 2005 Jun 1;38(11):1422-32. Review.


Mitogen-activated protein kinase-mediated phosphorylation of peroxiredoxin 6 regulates its phospholipase A(2) activity.

Wu Y, Feinstein SI, Manevich Y, Chowdhury I, Pak JH, Kazi A, Dodia C, Speicher DW, Fisher AB.

Biochem J. 2009 May 1;419(3):669-79. doi: 10.1042/BJ20082061.


Interaction of surfactant protein A with peroxiredoxin 6 regulates phospholipase A2 activity.

Wu YZ, Manevich Y, Baldwin JL, Dodia C, Yu K, Feinstein SI, Fisher AB.

J Biol Chem. 2006 Mar 17;281(11):7515-25. Epub 2005 Dec 5.


Peroxiredoxin 6 triggers melanoma cell growth by increasing arachidonic acid-dependent lipid signalling.

Schmitt A, Schmitz W, Hufnagel A, Schartl M, Meierjohann S.

Biochem J. 2015 Oct 15;471(2):267-79. doi: 10.1042/BJ20141204. Epub 2015 Aug 18.


MAPK/AP-1 signal pathway in tobacco smoke-induced cell proliferation and squamous metaplasia in the lungs of rats.

Zhong CY, Zhou YM, Douglas GC, Witschi H, Pinkerton KE.

Carcinogenesis. 2005 Dec;26(12):2187-95. Epub 2005 Jul 28.


H2O2-dependent hyperoxidation of peroxiredoxin 6 (Prdx6) plays a role in cellular toxicity via up-regulation of iPLA2 activity.

Kim SY, Jo HY, Kim MH, Cha YY, Choi SW, Shim JH, Kim TJ, Lee KY.

J Biol Chem. 2008 Nov 28;283(48):33563-8. doi: 10.1074/jbc.M806578200. Epub 2008 Sep 30.


Intracellular targeting of peroxiredoxin 6 to lysosomal organelles requires MAPK activity and binding to 14-3-3ε.

Sorokina EM, Feinstein SI, Zhou S, Fisher AB.

Am J Physiol Cell Physiol. 2011 Jun;300(6):C1430-41. doi: 10.1152/ajpcell.00285.2010. Epub 2011 Feb 23.


The phospholipase A2 activity of peroxiredoxin 6 promotes cancer cell death induced by tumor necrosis factor alpha in hepatocellular carcinoma.

Xu X, Lu D, Zhuang R, Wei X, Xie H, Wang C, Zhu Y, Wang J, Zhong C, Zhang X, Wei Q, He Z, Zhou L, Zheng S.

Mol Carcinog. 2016 Sep;55(9):1299-308. doi: 10.1002/mc.22371. Epub 2015 Aug 21.


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