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Chromosomal instability triggered by Rrm2b loss leads to IL-6 secretion and plasmacytic neoplasms.

Chang L, Guo R, Huang Q, Yen Y.

Cell Rep. 2013 May 30;3(5):1389-97. doi: 10.1016/j.celrep.2013.03.040. Epub 2013 May 2.


ATM mediates constitutive NF-kappaB activation in high-risk myelodysplastic syndrome and acute myeloid leukemia.

Grosjean-Raillard J, Tailler M, Adès L, Perfettini JL, Fabre C, Braun T, De Botton S, Fenaux P, Kroemer G.

Oncogene. 2009 Feb 26;28(8):1099-109. doi: 10.1038/onc.2008.457. Epub 2008 Dec 15.


RRM2B suppresses activation of the oxidative stress pathway and is up-regulated by p53 during senescence.

Kuo ML, Sy AJ, Xue L, Chi M, Lee MT, Yen T, Chiang MI, Chang L, Chu P, Yen Y.

Sci Rep. 2012;2:822. doi: 10.1038/srep00822. Epub 2012 Nov 8.


IL6-mediated suppression of miR-200c directs constitutive activation of inflammatory signaling circuit driving transformation and tumorigenesis.

Rokavec M, Wu W, Luo JL.

Mol Cell. 2012 Mar 30;45(6):777-89. doi: 10.1016/j.molcel.2012.01.015. Epub 2012 Feb 23.


Impaired function of p53R2 in Rrm2b-null mice causes severe renal failure through attenuation of dNTP pools.

Kimura T, Takeda S, Sagiya Y, Gotoh M, Nakamura Y, Arakawa H.

Nat Genet. 2003 Aug;34(4):440-5.


Tumor suppressor FOXO3 regulates ribonucleotide reductase subunit RRM2B and impacts on survival of cancer patients.

Cho EC, Kuo ML, Liu X, Yang L, Hsieh YC, Wang J, Cheng Y, Yen Y.

Oncotarget. 2014 Jul 15;5(13):4834-44.


Exclusive ubiquitination and sumoylation on overlapping lysine residues mediate NF-kappaB activation by the human T-cell leukemia virus tax oncoprotein.

Lamsoul I, Lodewick J, Lebrun S, Brasseur R, Burny A, Gaynor RB, Bex F.

Mol Cell Biol. 2005 Dec;25(23):10391-406.


Activation of peroxisome proliferator-activated receptor beta/delta inhibits lipopolysaccharide-induced cytokine production in adipocytes by lowering nuclear factor-kappaB activity via extracellular signal-related kinase 1/2.

Rodríguez-Calvo R, Serrano L, Coll T, Moullan N, Sánchez RM, Merlos M, Palomer X, Laguna JC, Michalik L, Wahli W, Vázquez-Carrera M.

Diabetes. 2008 Aug;57(8):2149-57. doi: 10.2337/db08-0176. Epub 2008 Apr 28.


RRM2B-Mediated Regulation of Mitochondrial Activity and Inflammation under Oxidative Stress.

Cho EC, Kuo ML, Cheng JH, Cheng YC, Hsieh YC, Liu YR, Hsieh RH, Yen Y.

Mediators Inflamm. 2015;2015:287345. doi: 10.1155/2015/287345. Epub 2015 May 18.


Induction of MET by ionizing radiation and its role in radioresistance and invasive growth of cancer.

De Bacco F, Luraghi P, Medico E, Reato G, Girolami F, Perera T, Gabriele P, Comoglio PM, Boccaccio C.

J Natl Cancer Inst. 2011 Apr 20;103(8):645-61. doi: 10.1093/jnci/djr093. Epub 2011 Apr 4.


An RNA-binding protein alphaCP-1 is involved in the STAT3-mediated suppression of NF-kappaB transcriptional activity.

Nishinakamura H, Minoda Y, Saeki K, Koga K, Takaesu G, Onodera M, Yoshimura A, Kobayashi T.

Int Immunol. 2007 May;19(5):609-19. Epub 2007 Mar 22.


IL-32γ inhibits cancer cell growth through inactivation of NF-κB and STAT3 signals.

Oh JH, Cho MC, Kim JH, Lee SY, Kim HJ, Park ES, Ban JO, Kang JW, Lee DH, Shim JH, Han SB, Moon DC, Park YH, Yu DY, Kim JM, Kim SH, Yoon DY, Hong JT.

Oncogene. 2011 Jul 28;30(30):3345-59. doi: 10.1038/onc.2011.52. Epub 2011 Mar 21.


Genistein sensitizes bladder cancer cells to HCPT treatment in vitro and in vivo via ATM/NF-κB/IKK pathway-induced apoptosis.

Wang Y, Wang H, Zhang W, Shao C, Xu P, Shi CH, Shi JG, Li YM, Fu Q, Xue W, Lei YH, Gao JY, Wang JY, Gao XP, Li JQ, Yuan JL, Zhang YT.

PLoS One. 2013;8(1):e50175. doi: 10.1371/journal.pone.0050175. Epub 2013 Jan 24.


Induction of a pro-apoptotic ATM-NF-kappaB pathway and its repression by ATR in response to replication stress.

Wu ZH, Miyamoto S.

EMBO J. 2008 Jul 23;27(14):1963-73. doi: 10.1038/emboj.2008.127. Epub 2008 Jun 26.


Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion.

Bourdon A, Minai L, Serre V, Jais JP, Sarzi E, Aubert S, Chrétien D, de Lonlay P, Paquis-Flucklinger V, Arakawa H, Nakamura Y, Munnich A, Rötig A.

Nat Genet. 2007 Jun;39(6):776-80. Epub 2007 May 7.


Requirement of NEMO/IKKγ for effective expansion of KRAS-induced precancerous lesions in the pancreas.

Maier HJ, Wagner M, Schips TG, Salem HH, Baumann B, Wirth T.

Oncogene. 2013 May 23;32(21):2690-5. doi: 10.1038/onc.2012.272. Epub 2012 Jul 2.


STAT3 regulates NF-kappaB recruitment to the IL-12p40 promoter in dendritic cells.

Hoentjen F, Sartor RB, Ozaki M, Jobin C.

Blood. 2005 Jan 15;105(2):689-96. Epub 2004 Jul 13.


Inhibitor of growth-4 promotes IkappaB promoter activation to suppress NF-kappaB signaling and innate immunity.

Coles AH, Gannon H, Cerny A, Kurt-Jones E, Jones SN.

Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11423-8. doi: 10.1073/pnas.0912116107. Epub 2010 Jun 7. Erratum in: Proc Natl Acad Sci U S A. 2012 Jan 17;109(3):994.

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