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Items: 1 to 20 of 112

1.

Intestinal acyl-CoA:diacylglycerol acyltransferase 2 overexpression enhances postprandial triglyceridemic response and exacerbates high fat diet-induced hepatic triacylglycerol storage.

Uchida A, Slipchenko MN, Eustaquio T, Leary JF, Cheng JX, Buhman KK.

Biochim Biophys Acta. 2013 Aug;1831(8):1377-85. doi: 10.1016/j.bbalip.2013.04.013. Epub 2013 May 2.

2.

Intestine-specific expression of acyl CoA:diacylglycerol acyltransferase 1 reverses resistance to diet-induced hepatic steatosis and obesity in Dgat1-/- mice.

Lee B, Fast AM, Zhu J, Cheng JX, Buhman KK.

J Lipid Res. 2010 Jul;51(7):1770-80. doi: 10.1194/jlr.M002311. Epub 2010 Feb 10.

3.

Dgat1 and Dgat2 regulate enterocyte triacylglycerol distribution and alter proteins associated with cytoplasmic lipid droplets in response to dietary fat.

Hung YH, Carreiro AL, Buhman KK.

Biochim Biophys Acta. 2017 Jun;1862(6):600-614. doi: 10.1016/j.bbalip.2017.02.014. Epub 2017 Feb 27.

PMID:
28249764
4.

Knockdown of acyl-CoA:diacylglycerol acyltransferase 2 with antisense oligonucleotide reduces VLDL TG and ApoB secretion in mice.

Liu Y, Millar JS, Cromley DA, Graham M, Crooke R, Billheimer JT, Rader DJ.

Biochim Biophys Acta. 2008 Mar;1781(3):97-104. doi: 10.1016/j.bbalip.2008.01.001. Epub 2008 Jan 17.

PMID:
18252207
5.

Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance.

Choi CS, Savage DB, Kulkarni A, Yu XX, Liu ZX, Morino K, Kim S, Distefano A, Samuel VT, Neschen S, Zhang D, Wang A, Zhang XM, Kahn M, Cline GW, Pandey SK, Geisler JG, Bhanot S, Monia BP, Shulman GI.

J Biol Chem. 2007 Aug 3;282(31):22678-88. Epub 2007 May 27.

6.

Specific role for acyl CoA:Diacylglycerol acyltransferase 1 (Dgat1) in hepatic steatosis due to exogenous fatty acids.

Villanueva CJ, Monetti M, Shih M, Zhou P, Watkins SM, Bhanot S, Farese RV Jr.

Hepatology. 2009 Aug;50(2):434-42. doi: 10.1002/hep.22980.

7.
8.

Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese mice.

Yu XX, Murray SF, Pandey SK, Booten SL, Bao D, Song XZ, Kelly S, Chen S, McKay R, Monia BP, Bhanot S.

Hepatology. 2005 Aug;42(2):362-71.

PMID:
16001399
9.

Roles of Acyl-CoA:Diacylglycerol Acyltransferases 1 and 2 in Triacylglycerol Synthesis and Secretion in Primary Hepatocytes.

Li C, Li L, Lian J, Watts R, Nelson R, Goodwin B, Lehner R.

Arterioscler Thromb Vasc Biol. 2015 May;35(5):1080-91. doi: 10.1161/ATVBAHA.114.304584. Epub 2015 Mar 19.

10.

Diacylglycerol acyltransferase-2 (DGAT2) and monoacylglycerol acyltransferase-2 (MGAT2) interact to promote triacylglycerol synthesis.

Jin Y, McFie PJ, Banman SL, Brandt C, Stone SJ.

J Biol Chem. 2014 Oct 10;289(41):28237-48. doi: 10.1074/jbc.M114.571190. Epub 2014 Aug 27.

11.

Diacylglycerol acyltransferase-1 inhibition enhances intestinal fatty acid oxidation and reduces energy intake in rats.

Schober G, Arnold M, Birtles S, Buckett LK, Pacheco-López G, Turnbull AV, Langhans W, Mansouri A.

J Lipid Res. 2013 May;54(5):1369-84. doi: 10.1194/jlr.M035154. Epub 2013 Feb 28.

12.

Pharmacological inhibition to examine the role of DGAT1 in dietary lipid absorption in rodents and humans.

Maciejewski BS, LaPerle JL, Chen D, Ghosh A, Zavadoski WJ, McDonald TS, Manion TB, Mather D, Patterson TA, Hanna M, Watkins S, Gibbs EM, Calle RA, Steppan CM.

Am J Physiol Gastrointest Liver Physiol. 2013 Jun 1;304(11):G958-69. doi: 10.1152/ajpgi.00384.2012. Epub 2013 Apr 4.

13.

Intestine-specific deletion of acyl-CoA:monoacylglycerol acyltransferase (MGAT) 2 protects mice from diet-induced obesity and glucose intolerance.

Nelson DW, Gao Y, Yen MI, Yen CL.

J Biol Chem. 2014 Jun 20;289(25):17338-49. doi: 10.1074/jbc.M114.555961. Epub 2014 May 1.

14.

Acylation of acylglycerols by acyl coenzyme A:diacylglycerol acyltransferase 1 (DGAT1). Functional importance of DGAT1 in the intestinal fat absorption.

Cheng D, Iqbal J, Devenny J, Chu CH, Chen L, Dong J, Seethala R, Keim WJ, Azzara AV, Lawrence RM, Pelleymounter MA, Hussain MM.

J Biol Chem. 2008 Oct 31;283(44):29802-11. doi: 10.1074/jbc.M800494200. Epub 2008 Sep 3.

15.

The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2.

Qi J, Lang W, Geisler JG, Wang P, Petrounia I, Mai S, Smith C, Askari H, Struble GT, Williams R, Bhanot S, Monia BP, Bayoumy S, Grant E, Caldwell GW, Todd MJ, Liang Y, Gaul MD, Demarest KT, Connelly MA.

J Lipid Res. 2012 Jun;53(6):1106-16. doi: 10.1194/jlr.M020156. Epub 2012 Apr 3.

16.

Involvement and mechanism of DGAT2 upregulation in the pathogenesis of alcoholic fatty liver disease.

Wang Z, Yao T, Song Z.

J Lipid Res. 2010 Nov;51(11):3158-65. doi: 10.1194/jlr.M007948. Epub 2010 Aug 25.

17.

Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver.

Monetti M, Levin MC, Watt MJ, Sajan MP, Marmor S, Hubbard BK, Stevens RD, Bain JR, Newgard CB, Farese RV Sr, Hevener AL, Farese RV Jr.

Cell Metab. 2007 Jul;6(1):69-78.

18.

Paradoxical coupling of triglyceride synthesis and fatty acid oxidation in skeletal muscle overexpressing DGAT1.

Liu L, Shi X, Choi CS, Shulman GI, Klaus K, Nair KS, Schwartz GJ, Zhang Y, Goldberg IJ, Yu YH.

Diabetes. 2009 Nov;58(11):2516-24. doi: 10.2337/db08-1096. Epub 2009 Aug 12.

19.

Methionine restriction prevents the progression of hepatic steatosis in leptin-deficient obese mice.

Malloy VL, Perrone CE, Mattocks DA, Ables GP, Caliendo NS, Orentreich DS, Orentreich N.

Metabolism. 2013 Nov;62(11):1651-61. doi: 10.1016/j.metabol.2013.06.012. Epub 2013 Aug 5.

PMID:
23928105
20.

Comparative effects of dietary fat types on hepatic enzyme activities related to the synthesis and oxidation of fatty acid and to lipogenesis in rats.

Takeuchi H, Nakamoto T, Mori Y, Kawakami M, Mabuchi H, Ohishi Y, Ichikawa N, Koike A, Masuda K.

Biosci Biotechnol Biochem. 2001 Aug;65(8):1748-54.

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