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Items: 1 to 20 of 109

1.

Molecular modelling, synthesis, cytotoxicity and anti-tumour mechanisms of 2-aryl-6-substituted quinazolinones as dual-targeted anti-cancer agents.

Hour MJ, Lee KH, Chen TL, Lee KT, Zhao Y, Lee HZ.

Br J Pharmacol. 2013 Aug;169(7):1574-86. doi: 10.1111/bph.12233.

2.

2-(Naphthalene-1-yl)-6-pyrrolidinyl-4-quinazolinone inhibits skin cancer M21 cell proliferation through aberrant expression of microtubules and the cell cycle.

Wu YC, Hour MJ, Leung WC, Wu CY, Liu WZ, Chang YH, Lee HZ.

J Pharmacol Exp Ther. 2011 Sep;338(3):942-51. doi: 10.1124/jpet.110.176115. Epub 2011 Jun 7.

3.

A novel antitubulin agent, DPQZ, induces cell apoptosis in human oral cancer cells through Ras/Raf inhibition and MAP kinases activation.

Hour MJ, Lee KT, Wu YC, Wu CY, You BJ, Chen TL, Lee HZ.

Arch Toxicol. 2013 May;87(5):835-46. doi: 10.1007/s00204-012-0991-3. Epub 2012 Dec 5.

PMID:
23212307
4.

The newly synthesized 2-arylnaphthyridin-4-one, CSC-3436, induces apoptosis of non-small cell lung cancer cells by inhibiting tubulin dynamics and activating CDK1.

Chang LC, Yu YL, Liu CY, Cheng YY, Chou RH, Hsieh MT, Lin HY, Hung HY, Huang LJ, Wu YC, Kuo SC.

Cancer Chemother Pharmacol. 2015 Jun;75(6):1303-15. doi: 10.1007/s00280-015-2765-0. Epub 2015 May 7.

PMID:
25947085
5.

Arsenic trioxide produces polymerization of microtubules and mitotic arrest before apoptosis in human tumor cell lines.

Ling YH, Jiang JD, Holland JF, Perez-Soler R.

Mol Pharmacol. 2002 Sep;62(3):529-38.

6.

Investigation of anti-tumor mechanisms of K2154: characterization of tubulin isotypes, mitotic arrest and apoptotic machinery.

Lu PH, Kung FL, Kuo SC, Chueh SC, Guh JH.

Naunyn Schmiedebergs Arch Pharmacol. 2006 Dec;374(3):223-33. Epub 2006 Nov 11.

PMID:
17102938
7.

Design and synthesis of aminostilbene-arylpropenones as tubulin polymerization inhibitors.

Kamal A, Kumar GB, Polepalli S, Shaik AB, Reddy VS, Reddy MK, Reddy ChR, Mahesh R, Kapure JS, Jain N.

ChemMedChem. 2014 Nov;9(11):2565-79. doi: 10.1002/cmdc.201402256. Epub 2014 Aug 21.

PMID:
25146959
8.
9.

CIL-102 interacts with microtubule polymerization and causes mitotic arrest following apoptosis in the human prostate cancer PC-3 cell line.

Huang YT, Huang DM, Guh JH, Chen IL, Tzeng CC, Teng CM.

J Biol Chem. 2005 Jan 28;280(4):2771-9. Epub 2004 Nov 9.

10.
11.

MJ-66 induces malignant glioma cells G2/M phase arrest and mitotic catastrophe through regulation of cyclin B1/Cdk1 complex.

Liu WT, Chen C, Lu IC, Kuo SC, Lee KH, Chen TL, Song TS, Lu YL, Gean PW, Hour MJ.

Neuropharmacology. 2014 Nov;86:219-27. doi: 10.1016/j.neuropharm.2014.07.014. Epub 2014 Aug 5.

12.

An overview on 2-arylquinolin-4(1H)-ones and related structures as tubulin polymerisation inhibitors.

Carta D, Ferlin MG.

Curr Top Med Chem. 2014;14(20):2322-45. Review.

PMID:
25440493
13.

Tubulin-binding agents down-regulate matrix metalloproteinase-2 and -9 in human hormone-refractory prostate cancer cells – a critical role of Cdk1 in mitotic entry.

Chang WL, Yu CC, Chen CS, Guh JH.

Biochem Pharmacol. 2015 Mar 1;94(1):12-21. doi: 10.1016/j.bcp.2015.01.005. Epub 2015 Jan 20.

PMID:
25615907
14.

Discovery of novel 2-N-aryl-substituted benzenesulfonamidoacetamides: orally bioavailable tubulin polymerization inhibitors with marked antitumor activities.

Liu Z, Zhou Z, Tian W, Fan X, Xue D, Yu L, Yu Q, Long YQ.

ChemMedChem. 2012 Apr;7(4):680-93. doi: 10.1002/cmdc.201100529. Epub 2012 Feb 6.

PMID:
22311585
15.

Synthesis and biological evaluation of quinazolin-4(3H)-one derivatives bearing dithiocarbamate side chain at C2-position as potential antitumor agents.

Ding PP, Gao M, Mao BB, Cao SL, Liu CH, Yang CR, Li ZF, Liao J, Zhao H, Li Z, Li J, Wang H, Xu X.

Eur J Med Chem. 2016 Jan 27;108:364-373. doi: 10.1016/j.ejmech.2015.11.044. Epub 2015 Nov 28.

PMID:
26703795
16.

Design, synthesis, and molecular docking studies of 2-(furan-2-yl)quinazolin-4-one derivatives as potential antiproliferative agents.

Ahmed MF, Belal A.

Arch Pharm (Weinheim). 2015 Jul;348(7):487-97. doi: 10.1002/ardp.201400468. Epub 2015 Apr 29.

PMID:
25921702
17.

Novel antitumour indole alkaloid, Jerantinine A, evokes potent G2/M cell cycle arrest targeting microtubules.

Raja VJ, Lim KH, Leong CO, Kam TS, Bradshaw TD.

Invest New Drugs. 2014 Oct;32(5):838-50. doi: 10.1007/s10637-014-0126-1. Epub 2014 Jun 15.

PMID:
24927857
18.

Discovery of 3-phenylquinolinylchalcone derivatives as potent and selective anticancer agents against breast cancers.

Tseng CH, Tzeng CC, Hsu CY, Cheng CM, Yang CN, Chen YL.

Eur J Med Chem. 2015 Jun 5;97:306-19. doi: 10.1016/j.ejmech.2015.04.054. Epub 2015 Apr 30.

PMID:
26005780
19.

The Bcl-2/xL inhibitor ABT-263 increases the stability of Mcl-1 mRNA and protein in hepatocellular carcinoma cells.

Wang B, Ni Z, Dai X, Qin L, Li X, Xu L, Lian J, He F.

Mol Cancer. 2014 Apr 30;13:98. doi: 10.1186/1476-4598-13-98.

20.

Phosphorylation of Bcl-2 is a marker of M phase events and not a determinant of apoptosis.

Ling YH, Tornos C, Perez-Soler R.

J Biol Chem. 1998 Jul 24;273(30):18984-91.

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