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Items: 1 to 20 of 89


Characterization of drug-induced transcriptional modules: towards drug repositioning and functional understanding.

Iskar M, Zeller G, Blattmann P, Campillos M, Kuhn M, Kaminska KH, Runz H, Gavin AC, Pepperkok R, van Noort V, Bork P.

Mol Syst Biol. 2013;9:662. doi: 10.1038/msb.2013.20.


Identification of transcription factors for drug-associated gene modules and biomedical implications.

Xiong M, Li B, Zhu Q, Wang YX, Zhang HY.

Bioinformatics. 2014 Feb 1;30(3):305-9. doi: 10.1093/bioinformatics/btt683. Epub 2013 Nov 20.


Comparative analysis of acute and chronic corticosteroid pharmacogenomic effects in rat liver: transcriptional dynamics and regulatory structures.

Nguyen TT, Almon RR, Dubois DC, Jusko WJ, Androulakis IP.

BMC Bioinformatics. 2010 Oct 14;11:515. doi: 10.1186/1471-2105-11-515.


In vitro gene regulatory networks predict in vivo function of liver.

Deng Y, Johnson DR, Guan X, Ang CY, Ai J, Perkins EJ.

BMC Syst Biol. 2010 Nov 12;4:153. doi: 10.1186/1752-0509-4-153.


Molecular conservation of estrogen-response associated with cell cycle regulation, hormonal carcinogenesis and cancer in zebrafish and human cancer cell lines.

Lam SH, Lee SG, Lin CY, Thomsen JS, Fu PY, Murthy KR, Li H, Govindarajan KR, Nick LC, Bourque G, Gong Z, Lufkin T, Liu ET, Mathavan S.

BMC Med Genomics. 2011 May 16;4:41. doi: 10.1186/1755-8794-4-41.


Genomewide analyses define different modes of transcriptional regulation by peroxisome proliferator-activated receptor-β/δ (PPARβ/δ).

Adhikary T, Kaddatz K, Finkernagel F, Schönbauer A, Meissner W, Scharfe M, Jarek M, Blöcker H, Müller-Brüsselbach S, Müller R.

PLoS One. 2011 Jan 19;6(1):e16344. doi: 10.1371/journal.pone.0016344.


Multi-tissue analysis of co-expression networks by higher-order generalized singular value decomposition identifies functionally coherent transcriptional modules.

Xiao X, Moreno-Moral A, Rotival M, Bottolo L, Petretto E.

PLoS Genet. 2014 Jan;10(1):e1004006. doi: 10.1371/journal.pgen.1004006. Epub 2014 Jan 2.


Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes.

Rushmore TH, Kong AN.

Curr Drug Metab. 2002 Oct;3(5):481-90. Review.


Systematic identification of functional plant modules through the integration of complementary data sources.

Heyndrickx KS, Vandepoele K.

Plant Physiol. 2012 Jul;159(3):884-901. doi: 10.1104/pp.112.196725. Epub 2012 May 15. Erratum in: Plant Physiol. 2012 aUG;159(4):1875.


Cross-talk between fatty acid and cholesterol metabolism mediated by liver X receptor-alpha.

Tobin KA, Steineger HH, Alberti S, Spydevold O, Auwerx J, Gustafsson JA, Nebb HI.

Mol Endocrinol. 2000 May;14(5):741-52.


Transcriptional data: a new gateway to drug repositioning?

Iorio F, Rittman T, Ge H, Menden M, Saez-Rodriguez J.

Drug Discov Today. 2013 Apr;18(7-8):350-7. doi: 10.1016/j.drudis.2012.07.014. Epub 2012 Aug 7.


The dissection of transcriptional modules regulated by various drugs of abuse in the mouse striatum.

Piechota M, Korostynski M, Solecki W, Gieryk A, Slezak M, Bilecki W, Ziolkowska B, Kostrzewa E, Cymerman I, Swiech L, Jaworski J, Przewlocki R.

Genome Biol. 2010;11(5):R48. doi: 10.1186/gb-2010-11-5-r48. Epub 2010 May 4.


Reconstruction of gene regulatory modules in cancer cell cycle by multi-source data integration.

Zhang Y, Xuan J, de los Reyes BG, Clarke R, Ressom HW.

PLoS One. 2010 Apr 21;5(4):e10268. doi: 10.1371/journal.pone.0010268.


Integrating systems biology sources illuminates drug action.

Gottlieb A, Altman RB.

Clin Pharmacol Ther. 2014 Jun;95(6):663-9. doi: 10.1038/clpt.2014.51. Epub 2014 Feb 27.


Transcriptional regulation of human and rat hepatic lipid metabolism by the grapefruit flavonoid naringenin: role of PPARalpha, PPARgamma and LXRalpha.

Goldwasser J, Cohen PY, Yang E, Balaguer P, Yarmush ML, Nahmias Y.

PLoS One. 2010 Aug 25;5(8):e12399. doi: 10.1371/journal.pone.0012399.


Pharmacogenomics of cardiovascular pharmacology: development of an informatics system for analysis of DNA microarray data with a focus on lipid metabolism.

Takahara Y, Kobayashi T, Takemoto K, Adachi T, Osaki K, Kawahara K, Tsujimoto G.

J Pharmacol Sci. 2008 May;107(1):1-7. Review.


Reconstruction of gene regulatory modules from RNA silencing of IFN-α modulators: experimental set-up and inference method.

Grassi A, Di Camillo B, Ciccarese F, Agnusdei V, Zanovello P, Amadori A, Finesso L, Indraccolo S, Toffolo GM.

BMC Genomics. 2016 Mar 12;17:228. doi: 10.1186/s12864-016-2525-5.


Characterization of the species-specificity of peroxisome proliferators in rat and human hepatocytes.

Ammerschlaeger M, Beigel J, Klein KU, Mueller SO.

Toxicol Sci. 2004 Apr;78(2):229-40. Epub 2004 Feb 19.


Projection of gene-protein networks to the functional space of the proteome and its application to analysis of organism complexity.

Kanapin AA, Mulder N, Kuznetsov VA.

BMC Genomics. 2010 Feb 10;11 Suppl 1:S4. doi: 10.1186/1471-2164-11-S1-S4.

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