Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 175

1.

The fatty acid receptor FFA1/GPR40 a decade later: how much do we know?

Mancini AD, Poitout V.

Trends Endocrinol Metab. 2013 Aug;24(8):398-407. doi: 10.1016/j.tem.2013.03.003. Epub 2013 Apr 27. Review.

PMID:
23631851
2.

The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse.

Steneberg P, Rubins N, Bartoov-Shifman R, Walker MD, Edlund H.

Cell Metab. 2005 Apr;1(4):245-58.

3.

Long-term in vitro treatment of INS-1 rat pancreatic β-cells by unsaturated free fatty acids protects cells against gluco- and lipotoxicities via activation of GPR40 receptors.

Tuo Y, Feng DD, Wang DF, Sun J, Li SB, Chen C.

Clin Exp Pharmacol Physiol. 2012 May;39(5):423-8. doi: 10.1111/j.1440-1681.2012.05691.x.

PMID:
22332921
4.

β-Arrestin Recruitment and Biased Agonism at Free Fatty Acid Receptor 1.

Mancini AD, Bertrand G, Vivot K, Carpentier É, Tremblay C, Ghislain J, Bouvier M, Poitout V.

J Biol Chem. 2015 Aug 21;290(34):21131-40. doi: 10.1074/jbc.M115.644450. Epub 2015 Jul 8.

5.

[Membrane fatty acid receptors in the β-cell: novel therapeutic targets for type 2 diabetes].

Mancini AD, Poitout V.

Med Sci (Paris). 2013 Aug-Sep;29(8-9):715-21. doi: 10.1051/medsci/2013298009. Epub 2013 Sep 5. Review. French.

6.

Free fatty acids increase cytosolic free calcium and stimulate insulin secretion from beta-cells through activation of GPR40.

Schnell S, Schaefer M, Schöfl C.

Mol Cell Endocrinol. 2007 Jan 15;263(1-2):173-80. Epub 2006 Nov 13.

PMID:
17101212
7.

Modulating GPR40: therapeutic promise and potential in diabetes.

Poitout V, Lin DC.

Drug Discov Today. 2013 Dec;18(23-24):1301-8. doi: 10.1016/j.drudis.2013.09.003. Epub 2013 Sep 16. Review.

PMID:
24051395
8.

The relationship between GPR40 and lipotoxicity of the pancreatic β-cells as well as the effect of pioglitazone.

Wu P, Yang L, Shen X.

Biochem Biophys Res Commun. 2010 Dec 3;403(1):36-9. doi: 10.1016/j.bbrc.2010.10.105. Epub 2010 Oct 29.

PMID:
21036144
9.

PPAR-γ activation increases insulin secretion through the up-regulation of the free fatty acid receptor GPR40 in pancreatic β-cells.

Kim HS, Hwang YC, Koo SH, Park KS, Lee MS, Kim KW, Lee MK.

PLoS One. 2013;8(1):e50128. doi: 10.1371/journal.pone.0050128. Epub 2013 Jan 23.

10.

G-protein-coupled receptor 40 (GPR40) expression and its regulation in human pancreatic islets: the role of type 2 diabetes and fatty acids.

Del Guerra S, Bugliani M, D'Aleo V, Del Prato S, Boggi U, Mosca F, Filipponi F, Lupi R.

Nutr Metab Cardiovasc Dis. 2010 Jan;20(1):22-5. doi: 10.1016/j.numecd.2009.02.008. Epub 2009 Sep 15.

PMID:
19758793
11.

GPR40: a therapeutic target for mediating insulin secretion (review).

Feng XT, Leng J, Xie Z, Li SL, Zhao W, Tang QL.

Int J Mol Med. 2012 Dec;30(6):1261-6. doi: 10.3892/ijmm.2012.1142. Epub 2012 Sep 26. Review.

PMID:
23023155
12.

GPR40, a free fatty acid receptor on pancreatic beta cells, regulates insulin secretion.

Itoh Y, Hinuma S.

Hepatol Res. 2005 Oct;33(2):171-3. Epub 2005 Oct 6.

PMID:
16214394
13.

GPR40 Agonists for the Treatment of Type 2 Diabetes Mellitus: Benefits and Challenges.

Mohammad S.

Curr Drug Targets. 2016;17(11):1292-300. Review.

PMID:
26648068
14.

A Single Amino Acid Mutation (R104P) in the E/DRY Motif of GPR40 Impairs Receptor Function.

Guo S, Zhang J, Zhang S, Li J.

PLoS One. 2015 Oct 27;10(10):e0141303. doi: 10.1371/journal.pone.0141303. eCollection 2015.

15.

Physiology and therapeutics of the free fatty acid receptor GPR40.

Huang H, Dai MH, Tao YX.

Prog Mol Biol Transl Sci. 2014;121:67-94. doi: 10.1016/B978-0-12-800101-1.00003-X. Review.

PMID:
24373235
16.

The fatty acid receptor GPR40 plays a role in insulin secretion in vivo after high-fat feeding.

Kebede M, Alquier T, Latour MG, Semache M, Tremblay C, Poitout V.

Diabetes. 2008 Sep;57(9):2432-7. doi: 10.2337/db08-0553. Epub 2008 Jun 16. Erratum in: Diabetes. 2008 Nov;57(11):3166.

17.

TAK-875, an orally available G protein-coupled receptor 40/free fatty acid receptor 1 agonist, enhances glucose-dependent insulin secretion and improves both postprandial and fasting hyperglycemia in type 2 diabetic rats.

Tsujihata Y, Ito R, Suzuki M, Harada A, Negoro N, Yasuma T, Momose Y, Takeuchi K.

J Pharmacol Exp Ther. 2011 Oct;339(1):228-37. doi: 10.1124/jpet.111.183772. Epub 2011 Jul 13.

18.

[Free fatty acid receptors and their physiological role in metabolic regulation].

Hirasawa A, Hara T, Ichimura A, Tsujimoto G.

Yakugaku Zasshi. 2011;131(12):1683-9. Review. Japanese.

19.

Conjugated linoleic acids mediate insulin release through islet G protein-coupled receptor FFA1/GPR40.

Schmidt J, Liebscher K, Merten N, Grundmann M, Mielenz M, Sauerwein H, Christiansen E, Due-Hansen ME, Ulven T, Ullrich S, Gomeza J, Drewke C, Kostenis E.

J Biol Chem. 2011 Apr 8;286(14):11890-4. doi: 10.1074/jbc.C110.200477. Epub 2011 Feb 21.

20.

Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules.

Briscoe CP, Peat AJ, McKeown SC, Corbett DF, Goetz AS, Littleton TR, McCoy DC, Kenakin TP, Andrews JL, Ammala C, Fornwald JA, Ignar DM, Jenkinson S.

Br J Pharmacol. 2006 Jul;148(5):619-28. Epub 2006 May 15.

Supplemental Content

Support Center