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Suppression of mitochondrial complex I influences cell metastatic properties.

He X, Zhou A, Lu H, Chen Y, Huang G, Yue X, Zhao P, Wu Y.

PLoS One. 2013 Apr 22;8(4):e61677. doi: 10.1371/journal.pone.0061677. Print 2013.


GRIM-19 inhibition induced autophagy through activation of ERK and HIF-1α not STAT3 in Hela cells.

Yue X, Zhao P, Wu K, Huang J, Zhang W, Wu Y, Liang X, He X.

Tumour Biol. 2016 Jul;37(7):9789-96. doi: 10.1007/s13277-016-4877-5. Epub 2016 Jan 25.


Tumor suppressive protein gene associated with retinoid-interferon-induced mortality (GRIM)-19 inhibits src-induced oncogenic transformation at multiple levels.

Kalakonda S, Nallar SC, Gong P, Lindner DJ, Goldblum SE, Reddy SP, Kalvakolanu DV.

Am J Pathol. 2007 Oct;171(4):1352-68. Epub 2007 Sep 6.


GRIM-19, a cell death regulatory protein, is essential for assembly and function of mitochondrial complex I.

Huang G, Lu H, Hao A, Ng DC, Ponniah S, Guo K, Lufei C, Zeng Q, Cao X.

Mol Cell Biol. 2004 Oct;24(19):8447-56.


The cell death regulator GRIM-19 is involved in HIV-1 induced T-cell apoptosis.

Tripathy MK, Ahmed Z, Ladha JS, Mitra D.

Apoptosis. 2010 Dec;15(12):1453-60. doi: 10.1007/s10495-010-0527-3.


Dysfunctions of cellular oxidative metabolism in patients with mutations in the NDUFS1 and NDUFS4 genes of complex I.

Iuso A, Scacco S, Piccoli C, Bellomo F, Petruzzella V, Trentadue R, Minuto M, Ripoli M, Capitanio N, Zeviani M, Papa S.

J Biol Chem. 2006 Apr 14;281(15):10374-80. Epub 2006 Feb 13.


ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis.

Ishikawa K, Takenaga K, Akimoto M, Koshikawa N, Yamaguchi A, Imanishi H, Nakada K, Honma Y, Hayashi J.

Science. 2008 May 2;320(5876):661-4. doi: 10.1126/science.1156906. Epub 2008 Apr 3.


Glutathione peroxidase 4 has a major role in protecting mitochondria from oxidative damage and maintaining oxidative phosphorylation complexes in gut epithelial cells.

Cole-Ezea P, Swan D, Shanley D, Hesketh J.

Free Radic Biol Med. 2012 Aug 1;53(3):488-97. doi: 10.1016/j.freeradbiomed.2012.05.029. Epub 2012 May 25.


NADPH oxidase-dependent formation of reactive oxygen species contributes to angiotensin II-induced epithelial-mesenchymal transition in rat peritoneal mesothelial cells.

Chang J, Jiang Z, Zhang H, Zhu H, Zhou SF, Yu X.

Int J Mol Med. 2011 Sep;28(3):405-12. doi: 10.3892/ijmm.2011.683. Epub 2011 Apr 28.


Supernumerary subunits NDUFA3, NDUFA5 and NDUFA12 are required for the formation of the extramembrane arm of human mitochondrial complex I.

Rak M, Rustin P.

FEBS Lett. 2014 May 2;588(9):1832-8. doi: 10.1016/j.febslet.2014.03.046. Epub 2014 Apr 6.


Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain.

Ricci JE, Muñoz-Pinedo C, Fitzgerald P, Bailly-Maitre B, Perkins GA, Yadava N, Scheffler IE, Ellisman MH, Green DR.

Cell. 2004 Jun 11;117(6):773-86.


Upregulation of the GRIM-19 gene suppresses invasion and metastasis of human gastric cancer SGC-7901 cell line.

Huang Y, Yang M, Yang H, Zeng Z.

Exp Cell Res. 2010 Aug 1;316(13):2061-70. doi: 10.1016/j.yexcr.2010.05.010. Epub 2010 May 15.


A heteroplasmic, not homoplasmic, mitochondrial DNA mutation promotes tumorigenesis via alteration in reactive oxygen species generation and apoptosis.

Park JS, Sharma LK, Li H, Xiang R, Holstein D, Wu J, Lechleiter J, Naylor SL, Deng JJ, Lu J, Bai Y.

Hum Mol Genet. 2009 May 1;18(9):1578-89. doi: 10.1093/hmg/ddp069. Epub 2009 Feb 10.


Complex I (NADH:ubiquinone oxidoreductase) is active in but non-essential for procyclic Trypanosoma brucei.

Verner Z, Cermáková P, Skodová I, Kriegová E, Horváth A, Lukes J.

Mol Biochem Parasitol. 2011 Feb;175(2):196-200. doi: 10.1016/j.molbiopara.2010.11.003. Epub 2010 Nov 11.


The import of the transcription factor STAT3 into mitochondria depends on GRIM-19, a component of the electron transport chain.

Tammineni P, Anugula C, Mohammed F, Anjaneyulu M, Larner AC, Sepuri NB.

J Biol Chem. 2013 Feb 15;288(7):4723-32. doi: 10.1074/jbc.M112.378984. Epub 2012 Dec 27.


GRIM-19 opposes reprogramming of glioblastoma cell metabolism via HIF1α destabilization.

Liu Q, Wang L, Wang Z, Yang Y, Tian J, Liu G, Guan D, Cao X, Zhang Y, Hao A.

Carcinogenesis. 2013 Aug;34(8):1728-36. doi: 10.1093/carcin/bgt125. Epub 2013 Apr 11.


The mitochondrial respiratory chain controls intracellular calcium signaling and NFAT activity essential for heart formation in Xenopus laevis.

Chen Y, Yuen WH, Fu J, Huang G, Melendez AJ, Ibrahim FB, Lu H, Cao X.

Mol Cell Biol. 2007 Sep;27(18):6420-32. Epub 2007 Jul 16.


Different mtDNA mutations modify tumor progression in dependence of the degree of respiratory complex I impairment.

Iommarini L, Kurelac I, Capristo M, Calvaruso MA, Giorgio V, Bergamini C, Ghelli A, Nanni P, De Giovanni C, Carelli V, Fato R, Lollini PL, Rugolo M, Gasparre G, Porcelli AM.

Hum Mol Genet. 2014 Mar 15;23(6):1453-66. doi: 10.1093/hmg/ddt533. Epub 2013 Oct 24.


GRIM-19 in Health and Disease.

Máximo V, Lima J, Soares P, Silva A, Bento I, Sobrinho-Simões M.

Adv Anat Pathol. 2008 Jan;15(1):46-53.


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