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PICK1 and ICA69 control insulin granule trafficking and their deficiencies lead to impaired glucose tolerance.

Cao M, Mao Z, Kam C, Xiao N, Cao X, Shen C, Cheng KK, Xu A, Lee KM, Jiang L, Xia J.

PLoS Biol. 2013;11(4):e1001541. doi: 10.1371/journal.pbio.1001541. Epub 2013 Apr 23.


PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance.

Holst B, Madsen KL, Jansen AM, Jin C, Rickhag M, Lund VK, Jensen M, Bhatia V, Sørensen G, Madsen AN, Xue Z, Møller SK, Woldbye D, Qvortrup K, Huganir R, Stamou D, Kjærulff O, Gether U.

PLoS Biol. 2013;11(4):e1001542. doi: 10.1371/journal.pbio.1001542. Epub 2013 Apr 23.


PICK1-ICA69 heteromeric BAR domain complex regulates synaptic targeting and surface expression of AMPA receptors.

Cao M, Xu J, Shen C, Kam C, Huganir RL, Xia J.

J Neurosci. 2007 Nov 21;27(47):12945-56.


C-terminal domain of ICA69 interacts with PICK1 and acts on trafficking of PICK1-PKCα complex and cerebellar plasticity.

Wang Z, Wang YN, Sun CL, Yang D, Su LD, Xie YJ, Zhou L, Wang Y, Shen Y.

PLoS One. 2013 Dec 16;8(12):e83862. doi: 10.1371/journal.pone.0083862. eCollection 2013 Dec 16.


Islet cell autoantigen of 69 kDa is an arfaptin-related protein associated with the Golgi complex of insulinoma INS-1 cells.

Spitzenberger F, Pietropaolo S, Verkade P, Habermann B, Lacas-Gervais S, Mziaut H, Pietropaolo M, Solimena M.

J Biol Chem. 2003 Jul 11;278(28):26166-73. Epub 2003 Apr 7.


ICA1L forms BAR-domain complexes with PICK1 and is crucial for acrosome formation in spermiogenesis.

He J, Xia M, Tsang WH, Chow KL, Xia J.

J Cell Sci. 2015 Oct 15;128(20):3822-36. doi: 10.1242/jcs.173534. Epub 2015 Aug 25.


ICA69 is a novel Rab2 effector regulating ER-Golgi trafficking in insulinoma cells.

Buffa L, Fuchs E, Pietropaolo M, Barr F, Solimena M.

Eur J Cell Biol. 2008 Apr;87(4):197-209. doi: 10.1016/j.ejcb.2007.11.003. Epub 2008 Jan 9.


A pair of crescent-shaped proteins shape vesicles at the golgi.

Robinson R.

PLoS Biol. 2013;11(4):e1001543. doi: 10.1371/journal.pbio.1001543. Epub 2013 Apr 23. No abstract available.


The BAR domain protein PICK1 controls vesicle number and size in adrenal chromaffin cells.

Pinheiro PS, Jansen AM, de Wit H, Tawfik B, Madsen KL, Verhage M, Gether U, Sørensen JB.

J Neurosci. 2014 Aug 6;34(32):10688-700. doi: 10.1523/JNEUROSCI.5132-13.2014.


PICK1 deficiency causes male infertility in mice by disrupting acrosome formation.

Xiao N, Kam C, Shen C, Jin W, Wang J, Lee KM, Jiang L, Xia J.

J Clin Invest. 2009 Apr;119(4):802-12. doi: 10.1172/JCI36230. Epub 2009 Mar 2.


Wolfram syndrome 1 gene (WFS1) product localizes to secretory granules and determines granule acidification in pancreatic beta-cells.

Hatanaka M, Tanabe K, Yanai A, Ohta Y, Kondo M, Akiyama M, Shinoda K, Oka Y, Tanizawa Y.

Hum Mol Genet. 2011 Apr 1;20(7):1274-84. doi: 10.1093/hmg/ddq568. Epub 2011 Jan 3.


BIG3 inhibits insulin granule biogenesis and insulin secretion.

Li H, Wei S, Cheng K, Gounko NV, Ericksen RE, Xu A, Hong W, Han W.

EMBO Rep. 2014 Jun;15(6):714-22. doi: 10.1002/embr.201338181. Epub 2014 Apr 7.


Cholesterol accumulation increases insulin granule size and impairs membrane trafficking.

Bogan JS, Xu Y, Hao M.

Traffic. 2012 Nov;13(11):1466-80. doi: 10.1111/j.1600-0854.2012.01407.x. Epub 2012 Sep 13.


Islet autoantigens: structure, function, localization, and regulation.

Arvan P, Pietropaolo M, Ostrov D, Rhodes CJ.

Cold Spring Harb Perspect Med. 2012 Aug 1;2(8). pii: a007658. doi: 10.1101/cshperspect.a007658. Review.


Loss of ICA69 potentiates long-lasting hyperalgesia after subcutaneous formalin injection into the mouse hindpaw.

Li QJ, Wang Z, Yao YX, Jin SH, Qian MZ, Li NN, Wang YN, Zhang YW, Chen BY, Jia DY, Shen Y, Wang JL.

Neurochem Res. 2015 Mar;40(3):579-90. doi: 10.1007/s11064-014-1503-z. Epub 2014 Dec 30.


Neuroendocrinology: regulated secretory cells go to the BAR for a bud.

Arvan P, Castle D.

Nat Rev Endocrinol. 2013 Aug;9(8):443-4. doi: 10.1038/nrendo.2013.121. Epub 2013 Jun 25.


Regulation of two insulin granule populations within the reserve pool by distinct calcium sources.

Hao M, Li X, Rizzo MA, Rocheleau JV, Dawant BM, Piston DW.

J Cell Sci. 2005 Dec 15;118(Pt 24):5873-84. Epub 2005 Nov 29.


Insulin granule biogenesis, trafficking and exocytosis.

Hou JC, Min L, Pessin JE.

Vitam Horm. 2009;80:473-506. doi: 10.1016/S0083-6729(08)00616-X. Review.


Impaired glucose tolerance in mice lacking cellular prion protein.

Strom A, Wang GS, Scott FW.

Pancreas. 2011 Mar;40(2):229-32.


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