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Items: 1 to 20 of 127

1.

LXR agonists: new potential therapeutic drug for neurodegenerative diseases.

Xu P, Li D, Tang X, Bao X, Huang J, Tang Y, Yang Y, Xu H, Fan X.

Mol Neurobiol. 2013 Dec;48(3):715-28. doi: 10.1007/s12035-013-8461-3. Epub 2013 Apr 27. Review.

PMID:
23625315
2.

The liver X receptor: control of cellular lipid homeostasis and beyond Implications for drug design.

Oosterveer MH, Grefhorst A, Groen AK, Kuipers F.

Prog Lipid Res. 2010 Oct;49(4):343-52. doi: 10.1016/j.plipres.2010.03.002. Epub 2010 Apr 2. Review.

PMID:
20363253
3.

Lipid metabolism and neuroinflammation in Alzheimer's disease: a role for liver X receptors.

Kang J, Rivest S.

Endocr Rev. 2012 Oct;33(5):715-46. doi: 10.1210/er.2011-1049. Epub 2012 Jul 5. Review.

PMID:
22766509
4.

Transcriptional and posttranscriptional control of cholesterol homeostasis by liver X receptors.

Tontonoz P.

Cold Spring Harb Symp Quant Biol. 2011;76:129-37. doi: 10.1101/sqb.2011.76.010702. Epub 2011 Aug 22. Review.

PMID:
21859674
5.

Liver X receptors as potential therapeutic targets in atherosclerosis.

Zhu Y, Li Y.

Clin Invest Med. 2009 Oct 1;32(5):E383-94. Review.

PMID:
19796580
6.

Role of liver X receptors in cholesterol efflux and inflammatory signaling (review).

Zhu R, Ou Z, Ruan X, Gong J.

Mol Med Rep. 2012 Apr;5(4):895-900. doi: 10.3892/mmr.2012.758. Epub 2012 Jan 17. Review.

7.

Liver X receptors as integrators of metabolic and inflammatory signaling.

Zelcer N, Tontonoz P.

J Clin Invest. 2006 Mar;116(3):607-14. Review.

8.

Natural modulators of liver X receptors.

Huang C.

J Integr Med. 2014 Mar;12(2):76-85. doi: 10.1016/S2095-4964(14)60013-3. Review.

PMID:
24666673
9.

LXR-activating oxysterols induce the expression of inflammatory markers in endothelial cells through LXR-independent mechanisms.

Morello F, Saglio E, Noghero A, Schiavone D, Williams TA, Verhovez A, Bussolino F, Veglio F, Mulatero P.

Atherosclerosis. 2009 Nov;207(1):38-44. doi: 10.1016/j.atherosclerosis.2009.04.001. Epub 2009 Apr 11.

PMID:
19426978
10.

Targeting liver X receptors in inflammation.

Steffensen KR, Jakobsson T, Gustafsson JÅ.

Expert Opin Ther Targets. 2013 Aug;17(8):977-90. doi: 10.1517/14728222.2013.806490. Epub 2013 Jun 6. Review.

PMID:
23738533
11.

The discovery of tertiary-amine LXR agonists with potent cholesterol efflux activity in macrophages.

Marino JP Jr, Kallander LS, Ma C, Oh HJ, Lee D, Gaitanopoulos DE, Krawiec JA, Parks DJ, Webb CL, Ziegler K, Jaye M, Thompson SK.

Bioorg Med Chem Lett. 2009 Oct 1;19(19):5617-21. doi: 10.1016/j.bmcl.2009.08.036. Epub 2009 Aug 13.

PMID:
19717304
12.

Liver X receptor-mediated gene regulation and cholesterol homeostasis in brain: relevance to Alzheimer's disease therapeutics.

Cao G, Bales KR, DeMattos RB, Paul SM.

Curr Alzheimer Res. 2007 Apr;4(2):179-84. Review.

PMID:
17430244
13.

A systems biology approach to the hepatic role of the oxysterol receptor LXR in the regulation of lipogenesis highlights a cross-talk with PPARα.

Ducheix S, Podechard N, Lasserre F, Polizzi A, Pommier A, Murzilli S, Di Lisio C, D'Amore S, Bertrand-Michel J, Montagner A, Pineau T, Loiseau N, Lobaccaro JM, Martin PG, Guillou H.

Biochimie. 2013 Mar;95(3):556-67. doi: 10.1016/j.biochi.2012.09.028. Epub 2012 Oct 10.

PMID:
23063693
14.

Liver X receptors, nervous system, and lipid metabolism.

Cermenati G, Brioschi E, Abbiati F, Melcangi RC, Caruso D, Mitro N.

J Endocrinol Invest. 2013 Jun;36(6):435-43. doi: 10.3275/8941. Epub 2013 Apr 18. Review.

PMID:
23609963
15.

Reciprocal negative cross-talk between liver X receptors (LXRs) and STAT1: effects on IFN-γ-induced inflammatory responses and LXR-dependent gene expression.

Pascual-García M, Rué L, León T, Julve J, Carbó JM, Matalonga J, Auer H, Celada A, Escolà-Gil JC, Steffensen KR, Pérez-Navarro E, Valledor AF.

J Immunol. 2013 Jun 15;190(12):6520-32. doi: 10.4049/jimmunol.1201393. Epub 2013 May 17.

16.

Liver X receptor biology and pharmacology: new pathways, challenges and opportunities.

Jakobsson T, Treuter E, Gustafsson JÅ, Steffensen KR.

Trends Pharmacol Sci. 2012 Jul;33(7):394-404. doi: 10.1016/j.tips.2012.03.013. Epub 2012 Apr 27. Review.

PMID:
22541735
17.

Liver X receptor and retinoid X receptor agonists inhibit inflammatory responses of microglia and astrocytes.

Zhang-Gandhi CX, Drew PD.

J Neuroimmunol. 2007 Feb;183(1-2):50-9. Epub 2006 Dec 18.

18.

Liver X receptor-dependent inhibition of microglial nitric oxide synthase 2.

Secor McVoy JR, Oughli HA, Oh U.

J Neuroinflammation. 2015 Feb 10;12:27. doi: 10.1186/s12974-015-0247-2.

19.

A novel role for c-Jun N-terminal kinase and phosphoinositide 3-kinase in the liver X receptor-mediated induction of macrophage gene expression.

Huwait EA, Greenow KR, Singh NN, Ramji DP.

Cell Signal. 2011 Mar;23(3):542-9. doi: 10.1016/j.cellsig.2010.11.002. Epub 2010 Nov 8.

20.

Liver X receptors (LXRs). Part I: structure, function, regulation of activity, and role in lipid metabolism.

Wójcicka G, Jamroz-Wiśniewska A, Horoszewicz K, Bełtowski J.

Postepy Hig Med Dosw (Online). 2007 Dec 3;61:736-59. Review.

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