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Items: 1 to 20 of 81

1.

LRIG1 modulates aggressiveness of head and neck cancers by regulating EGFR-MAPK-SPHK1 signaling and extracellular matrix remodeling.

Sheu JJ, Lee CC, Hua CH, Li CI, Lai MT, Lee SC, Cheng J, Chen CM, Chan C, Chao SC, Chen JY, Chang JY, Lee CH.

Oncogene. 2014 Mar 13;33(11):1375-84. doi: 10.1038/onc.2013.98. Epub 2013 Apr 29.

PMID:
23624915
2.

Restoration of LRIG1 suppresses bladder cancer cell growth by directly targeting EGFR activity.

Chang L, Shi R, Yang T, Li F, Li G, Guo Y, Lang B, Yang W, Zhuang Q, Xu H.

J Exp Clin Cancer Res. 2013 Dec 8;32:101. doi: 10.1186/1756-9966-32-101.

3.

LRIG1, a 3p tumor suppressor, represses EGFR signaling and is a novel epigenetic silenced gene in colorectal cancer.

Kou C, Zhou T, Han X, Zhuang H, Qian H.

Biochem Biophys Res Commun. 2015 Aug 21;464(2):519-25. doi: 10.1016/j.bbrc.2015.06.173. Epub 2015 Jul 6.

PMID:
26159916
4.

SRC family kinases mediate epidermal growth factor receptor ligand cleavage, proliferation, and invasion of head and neck cancer cells.

Zhang Q, Thomas SM, Xi S, Smithgall TE, Siegfried JM, Kamens J, Gooding WE, Grandis JR.

Cancer Res. 2004 Sep 1;64(17):6166-73.

5.

A soluble ectodomain of LRIG1 inhibits cancer cell growth by attenuating basal and ligand-dependent EGFR activity.

Goldoni S, Iozzo RA, Kay P, Campbell S, McQuillan A, Agnew C, Zhu JX, Keene DR, Reed CC, Iozzo RV.

Oncogene. 2007 Jan 18;26(3):368-81. Epub 2006 Jul 17.

PMID:
16847455
6.

Paracrine regulation of growth factor signaling by shed leucine-rich repeats and immunoglobulin-like domains 1.

Yi W, Holmlund C, Nilsson J, Inui S, Lei T, Itami S, Henriksson R, Hedman H.

Exp Cell Res. 2011 Feb 15;317(4):504-12. doi: 10.1016/j.yexcr.2010.11.005. Epub 2010 Nov 16.

PMID:
21087604
7.

LRIG1 expression in colorectal cancer.

Ljuslinder I, Golovleva I, Palmqvist R, Oberg A, Stenling R, Jonsson Y, Hedman H, Henriksson R, Malmer B.

Acta Oncol. 2007;46(8):1118-22.

PMID:
17851870
8.
9.

Protein kinase C zeta mediates epidermal growth factor-induced growth of head and neck tumor cells by regulating mitogen-activated protein kinase.

Cohen EE, Lingen MW, Zhu B, Zhu H, Straza MW, Pierce C, Martin LE, Rosner MR.

Cancer Res. 2006 Jun 15;66(12):6296-303.

10.

Increased copy number at 3p14 in breast cancer.

Ljuslinder I, Malmer B, Golovleva I, Thomasson M, Grankvist K, Höckenström T, Emdin S, Jonsson Y, Hedman H, Henriksson R.

Breast Cancer Res. 2005;7(5):R719-27. Epub 2005 Jul 6.

11.

LRIG1 and epidermal growth factor receptor in renal cell carcinoma: a quantitative RT--PCR and immunohistochemical analysis.

Thomasson M, Hedman H, Guo D, Ljungberg B, Henriksson R.

Br J Cancer. 2003 Oct 6;89(7):1285-9. Erratum in: Br J Cancer. 2004 Jun 14;90(12):2425.

12.

Downregulation of LRIG1 expression by RNA interference promotes the aggressive properties of glioma cells via EGFR/Akt/c-Myc activation.

Xie R, Yang H, Xiao Q, Mao F, Zhang S, Ye F, Wan F, Wang B, Lei T, Guo D.

Oncol Rep. 2013 Jan;29(1):177-84. doi: 10.3892/or.2012.2102. Epub 2012 Oct 23.

PMID:
23124613
13.

Mitogenic effects of gastrin-releasing peptide in head and neck squamous cancer cells are mediated by activation of the epidermal growth factor receptor.

Lui VW, Thomas SM, Zhang Q, Wentzel AL, Siegfried JM, Li JY, Grandis JR.

Oncogene. 2003 Sep 18;22(40):6183-93.

PMID:
13679857
14.

[Molecular mechanism of LRIG1 cDNA-induced apoptosis in human glioma cell line H4].

Ye F, Guo DS, Niu HQ, Tao SZ, Ou YB, Lu YP, Lei T.

Ai Zheng. 2004 Oct;23(10):1149-54. Chinese.

PMID:
15473925
15.

Adenovirus-mediated LRIG1 expression enhances the chemosensitivity of bladder cancer cells to cisplatin.

Yan Z, Jiang J, Li F, Yang W, Xie G, Zhou C, Xia S, Cheng Y.

Oncol Rep. 2015 Apr;33(4):1791-8. doi: 10.3892/or.2015.3807. Epub 2015 Feb 16.

PMID:
25695283
16.

Deoxycholic acid (DCA) causes ligand-independent activation of epidermal growth factor receptor (EGFR) and FAS receptor in primary hepatocytes: inhibition of EGFR/mitogen-activated protein kinase-signaling module enhances DCA-induced apoptosis.

Qiao L, Studer E, Leach K, McKinstry R, Gupta S, Decker R, Kukreja R, Valerie K, Nagarkatti P, El Deiry W, Molkentin J, Schmidt-Ullrich R, Fisher PB, Grant S, Hylemon PB, Dent P.

Mol Biol Cell. 2001 Sep;12(9):2629-45.

17.
18.

Overexpression of EGFR in head and neck squamous cell carcinoma is associated with inactivation of SH3GL2 and CDC25A genes.

Maiti GP, Mondal P, Mukherjee N, Ghosh A, Ghosh S, Dey S, Chakrabarty J, Roy A, Biswas J, Roychoudhury S, Panda CK.

PLoS One. 2013 May 10;8(5):e63440. doi: 10.1371/journal.pone.0063440. Print 2013.

19.

[Gene therapy study on bladder cancer with recombinant adenoviral vector carrying LRIG1 gene driven by Survivin promoter].

Yan ZJ, Cheng Y, Jiang JH, Hu JS, Shi XD.

Zhonghua Wai Ke Za Zhi. 2012 Aug;50(8):732-6. Chinese.

PMID:
23157908
20.

Is LRIG1 a tumour suppressor gene at chromosome 3p14.3?

Hedman H, Nilsson J, Guo D, Henriksson R.

Acta Oncol. 2002;41(4):352-4.

PMID:
12234026

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