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Impaired PIASy-Tip60 signaling weakens activation of p53 in melanoma.

Lakhter AJ, Kanginakudru S, Warren S, Touloukian CE, Boissy RE, Naidu SR.

Melanoma Res. 2013 Jun;23(3):213-7. doi: 10.1097/CMR.0b013e328361056d.


PIASy-mediated Tip60 sumoylation regulates p53-induced autophagy.

Naidu SR, Lakhter AJ, Androphy EJ.

Cell Cycle. 2012 Jul 15;11(14):2717-28. doi: 10.4161/cc.21091. Epub 2012 Jul 15.


The E3 SUMO ligase PIASy is a regulator of cellular senescence and apoptosis.

Bischof O, Schwamborn K, Martin N, Werner A, Sustmann C, Grosschedl R, Dejean A.

Mol Cell. 2006 Jun 23;22(6):783-94.


The Stress-responsive Gene ATF3 Mediates Dichotomous UV Responses by Regulating the Tip60 and p53 Proteins.

Cui H, Li X, Han C, Wang QE, Wang H, Ding HF, Zhang J, Yan C.

J Biol Chem. 2016 May 13;291(20):10847-57. doi: 10.1074/jbc.M115.713099. Epub 2016 Mar 18.


Negative regulation of the acetyltransferase TIP60-p53 interplay by UHRF1 (ubiquitin-like with PHD and RING finger domains 1).

Dai C, Shi D, Gu W.

J Biol Chem. 2013 Jul 5;288(27):19581-92. doi: 10.1074/jbc.M113.476606. Epub 2013 May 15.


Analysis of the functional integrity of the p53 tumor-suppressor gene in malignant melanoma.

Knopf A, Plettenberg C, Pickhard A, Bas M, Reifenberger J, Bier H, Balz V.

Melanoma Res. 2011 Oct;21(5):380-8. doi: 10.1097/CMR.0b013e328347ee04.


Deubiquitination of Tip60 by USP7 determines the activity of the p53-dependent apoptotic pathway.

Dar A, Shibata E, Dutta A.

Mol Cell Biol. 2013 Aug;33(16):3309-20. doi: 10.1128/MCB.00358-13. Epub 2013 Jun 17.


The role of miR-18b in MDM2-p53 pathway signaling and melanoma progression.

Dar AA, Majid S, Rittsteuer C, de Semir D, Bezrookove V, Tong S, Nosrati M, Sagebiel R, Miller JR 3rd, Kashani-Sabet M.

J Natl Cancer Inst. 2013 Mar 20;105(6):433-42. doi: 10.1093/jnci/djt003. Epub 2013 Jan 30.


Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response.

Gorrini C, Squatrito M, Luise C, Syed N, Perna D, Wark L, Martinato F, Sardella D, Verrecchia A, Bennett S, Confalonieri S, Cesaroni M, Marchesi F, Gasco M, Scanziani E, Capra M, Mai S, Nuciforo P, Crook T, Lough J, Amati B.

Nature. 2007 Aug 30;448(7157):1063-7.


Functional characterization of TIP60 sumoylation in UV-irradiated DNA damage response.

Cheng Z, Ke Y, Ding X, Wang F, Wang H, Wang W, Ahmed K, Liu Z, Xu Y, Aikhionbare F, Yan H, Liu J, Xue Y, Yu J, Powell M, Liang S, Wu Q, Reddy SE, Hu R, Huang H, Jin C, Yao X.

Oncogene. 2008 Feb 7;27(7):931-41. Epub 2007 Aug 20. Erratum in: Oncogene. 2008 Mar 13;27(12):1812. Wang, W [added]; Yu, J [added]; Wu, Q [added].


The stress-responsive gene ATF3 regulates the histone acetyltransferase Tip60.

Cui H, Guo M, Xu D, Ding ZC, Zhou G, Ding HF, Zhang J, Tang Y, Yan C.

Nat Commun. 2015 Apr 13;6:6752. doi: 10.1038/ncomms7752.


Directing p53 to induce autophagy.

Mayo LD.

Cell Cycle. 2012 Sep 15;11(18):3353-4. doi: 10.4161/cc.21849. Epub 2012 Aug 23.


The p53 binding protein PDCD5 is not rate-limiting in DNA damage induced cell death.

Bock FJ, Tanzer MC, Haschka MD, Krumschnabel G, Sohm B, Goetsch K, Kofler R, Villunger A.

Sci Rep. 2015 Jun 11;5:11268. doi: 10.1038/srep11268.


ING5 is a Tip60 cofactor that acetylates p53 in response to DNA damage.

Liu N, Wang J, Wang J, Wang R, Liu Z, Yu Y, Lu H.

Cancer Res. 2013 Jun 15;73(12):3749-60. doi: 10.1158/0008-5472.CAN-12-3684. Epub 2013 Apr 10.


Phosphorylation of protein inhibitor of activated STAT1 (PIAS1) by MAPK-activated protein kinase-2 inhibits endothelial inflammation via increasing both PIAS1 transrepression and SUMO E3 ligase activity.

Heo KS, Chang E, Takei Y, Le NT, Woo CH, Sullivan MA, Morrell C, Fujiwara K, Abe J.

Arterioscler Thromb Vasc Biol. 2013 Feb;33(2):321-9. doi: 10.1161/ATVBAHA.112.300619. Epub 2012 Nov 29.


High-level expression of wild-type p53 in melanoma cells is frequently associated with inactivity in p53 reporter gene assays.

Houben R, Hesbacher S, Schmid CP, Kauczok CS, Flohr U, Haferkamp S, Müller CS, Schrama D, Wischhusen J, Becker JC.

PLoS One. 2011;6(7):e22096. doi: 10.1371/journal.pone.0022096. Epub 2011 Jul 8.


PIASy-mediated sumoylation of SREBP1c regulates hepatic lipid metabolism upon fasting signaling.

Lee GY, Jang H, Lee JH, Huh JY, Choi S, Chung J, Kim JB.

Mol Cell Biol. 2014 Mar;34(6):926-38. doi: 10.1128/MCB.01166-13. Epub 2013 Dec 30. Erratum in: Mol Cell Biol. 2014 May;34(9):1720.


PIASy mediates NEMO sumoylation and NF-kappaB activation in response to genotoxic stress.

Mabb AM, Wuerzberger-Davis SM, Miyamoto S.

Nat Cell Biol. 2006 Sep;8(9):986-93. Epub 2006 Aug 13.


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