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Items: 1 to 20 of 168

1.

PTEN protein phosphatase activity regulates hepatitis C virus secretion through modulation of cholesterol metabolism.

Peyrou M, Clément S, Maier C, Bourgoin L, Branche E, Conzelmann S, Kaddai V, Foti M, Negro F.

J Hepatol. 2013 Sep;59(3):420-6. doi: 10.1016/j.jhep.2013.04.012. Epub 2013 Apr 23.

PMID:
23623999
2.

Down-regulation of phosphatase and tensin homolog by hepatitis C virus core 3a in hepatocytes triggers the formation of large lipid droplets.

Clément S, Peyrou M, Sanchez-Pareja A, Bourgoin L, Ramadori P, Suter D, Vinciguerra M, Guilloux K, Pascarella S, Rubbia-Brandt L, Negro F, Foti M.

Hepatology. 2011 Jul;54(1):38-49. doi: 10.1002/hep.24340.

PMID:
21465511
3.

Arylacetamide deacetylase: a novel host factor with important roles in the lipolysis of cellular triacylglycerol stores, VLDL assembly and HCV production.

Nourbakhsh M, Douglas DN, Pu CH, Lewis JT, Kawahara T, Lisboa LF, Wei E, Asthana S, Quiroga AD, Law LM, Chen C, Addison WR, Nelson R, Houghton M, Lehner R, Kneteman NM.

J Hepatol. 2013 Aug;59(2):336-43. doi: 10.1016/j.jhep.2013.03.022. Epub 2013 Mar 28.

PMID:
23542347
4.

Hepatitis C Virus Increases Occludin Expression via the Upregulation of Adipose Differentiation-Related Protein.

Branche E, Conzelmann S, Parisot C, Bedert L, Lévy PL, Bartosch B, Clément S, Negro F.

PLoS One. 2016 Jan 5;11(1):e0146000. doi: 10.1371/journal.pone.0146000. eCollection 2016.

5.

Inhibition of IRS-1 by hepatitis C virus infection leads to insulin resistance in a PTEN-dependent manner.

Gao TT, Qin ZL, Ren H, Zhao P, Qi ZT.

Virol J. 2015 Feb 3;12:12. doi: 10.1186/s12985-015-0241-4.

6.

N-Myc Downstream-Regulated Gene 1 Restricts Hepatitis C Virus Propagation by Regulating Lipid Droplet Biogenesis and Viral Assembly.

Schweitzer CJ, Zhang F, Boyer A, Valdez K, Cam M, Liang TJ.

J Virol. 2018 Jan 2;92(2). pii: e01166-17. doi: 10.1128/JVI.01166-17. Print 2018 Jan 15.

7.

Modulation of triglyceride and cholesterol ester synthesis impairs assembly of infectious hepatitis C virus.

Liefhebber JM, Hague CV, Zhang Q, Wakelam MJ, McLauchlan J.

J Biol Chem. 2014 Aug 1;289(31):21276-88. doi: 10.1074/jbc.M114.582999. Epub 2014 Jun 10.

8.

Treatment with PTEN-Long protein inhibits hepatitis C virus replication.

Wu Q, Li Z, Liu Q.

Virology. 2017 Nov;511:1-8. doi: 10.1016/j.virol.2017.08.002. Epub 2017 Aug 4.

9.

FIG4 is a hepatitis C virus particle-bound protein implicated in virion morphogenesis and infectivity with cholesteryl ester modulation potential.

Cottarel J, Plissonnier ML, Kullolli M, Pitteri S, Clément S, Millarte V, Si-Ahmed SN, Farhan H, Zoulim F, Parent R.

J Gen Virol. 2016 Jan;97(1):69-81. doi: 10.1099/jgv.0.000331. Epub 2015 Oct 29.

PMID:
26519381
10.

HCV 3a core protein increases lipid droplet cholesteryl ester content via a mechanism dependent on sphingolipid biosynthesis.

Loizides-Mangold U, Clément S, Alfonso-Garcia A, Branche E, Conzelmann S, Parisot C, Potma EO, Riezman H, Negro F.

PLoS One. 2014 Dec 18;9(12):e115309. doi: 10.1371/journal.pone.0115309. eCollection 2014.

11.

Up-regulation of the ATP-binding cassette transporter A1 inhibits hepatitis C virus infection.

Bocchetta S, Maillard P, Yamamoto M, Gondeau C, Douam F, Lebreton S, Lagaye S, Pol S, Helle F, Plengpanich W, Guérin M, Bourgine M, Michel ML, Lavillette D, Roingeard P, le Goff W, Budkowska A.

PLoS One. 2014 Mar 19;9(3):e92140. doi: 10.1371/journal.pone.0092140. eCollection 2014.

12.

Forkhead box transcription factor regulation and lipid accumulation by hepatitis C virus.

Bose SK, Kim H, Meyer K, Wolins N, Davidson NO, Ray R.

J Virol. 2014 Apr;88(8):4195-203. doi: 10.1128/JVI.03327-13. Epub 2014 Jan 29.

13.

Hepatitis C Virus-Induced Degradation of Cell Death-Inducing DFFA-Like Effector B Leads to Hepatic Lipid Dysregulation.

Lee EM, Alsagheir A, Wu X, Hammack C, McLauchlan J, Watanabe N, Wakita T, Kneteman NM, Douglas DN, Tang H.

J Virol. 2016 Mar 28;90(8):4174-85. doi: 10.1128/JVI.02891-15. Print 2016 Apr.

14.

Hepatitis C virus NS5A drives a PTEN-PI3K/Akt feedback loop to support cell survival.

Cheng D, Zhang L, Yang G, Zhao L, Peng F, Tian Y, Xiao X, Chung RT, Gong G.

Liver Int. 2015 Jun;35(6):1682-91. doi: 10.1111/liv.12733. Epub 2014 Dec 4.

PMID:
25388655
15.

Simvastatin and metformin inhibit cell growth in hepatitis C virus infected cells via mTOR increasing PTEN and autophagy.

Del Campo JA, García-Valdecasas M, Gil-Gómez A, Rojas Á, Gallego P, Ampuero J, Gallego-Durán R, Pastor H, Grande L, Padillo FJ, Muntané J, Romero-Gómez M.

PLoS One. 2018 Jan 31;13(1):e0191805. doi: 10.1371/journal.pone.0191805. eCollection 2018.

16.

Hepatitis C virus, cholesterol and lipoproteins--impact for the viral life cycle and pathogenesis of liver disease.

Felmlee DJ, Hafirassou ML, Lefevre M, Baumert TF, Schuster C.

Viruses. 2013 May 23;5(5):1292-324. doi: 10.3390/v5051292. Review.

17.

Avasimibe: A novel hepatitis C virus inhibitor that targets the assembly of infectious viral particles.

Hu L, Li J, Cai H, Yao W, Xiao J, Li YP, Qiu X, Xia H, Peng T.

Antiviral Res. 2017 Dec;148:5-14. doi: 10.1016/j.antiviral.2017.10.016. Epub 2017 Oct 23.

PMID:
29074218
18.

Proteomic profiling of lipid droplet proteins in hepatoma cell lines expressing hepatitis C virus core protein.

Sato S, Fukasawa M, Yamakawa Y, Natsume T, Suzuki T, Shoji I, Aizaki H, Miyamura T, Nishijima M.

J Biochem. 2006 May;139(5):921-30.

PMID:
16751600
19.

Release of Infectious Hepatitis C Virus from Huh7 Cells Occurs via a trans-Golgi Network-to-Endosome Pathway Independent of Very-Low-Density Lipoprotein Secretion.

Mankouri J, Walter C, Stewart H, Bentham M, Park WS, Heo WD, Fukuda M, Griffin S, Harris M.

J Virol. 2016 Jul 27;90(16):7159-70. doi: 10.1128/JVI.00826-16. Print 2016 Aug 15.

20.

The role of PTEN - HCV core interaction in hepatitis C virus replication.

Wu Q, Li Z, Mellor P, Zhou Y, Anderson DH, Liu Q.

Sci Rep. 2017 Jun 16;7(1):3695. doi: 10.1038/s41598-017-03052-w.

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