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The microRNA miR-181 is a critical cellular metabolic rheostat essential for NKT cell ontogenesis and lymphocyte development and homeostasis.

Henao-Mejia J, Williams A, Goff LA, Staron M, Licona-Limón P, Kaech SM, Nakayama M, Rinn JL, Flavell RA.

Immunity. 2013 May 23;38(5):984-97. doi: 10.1016/j.immuni.2013.02.021. Epub 2013 Apr 25.


miR-181 and metabolic regulation in the immune system.

Williams A, Henao-Mejia J, Harman CC, Flavell RA.

Cold Spring Harb Symp Quant Biol. 2013;78:223-30. doi: 10.1101/sqb.2013.78.020024. Epub 2013 Oct 25.


T cell metabolism: microRNAs cap PTEN to feed the expanding crowd.

Vacchio MS, Bosselut R.

Immunity. 2013 May 23;38(5):847-8. doi: 10.1016/j.immuni.2013.05.006. No abstract available.


miR-214 promotes osteoclastogenesis by targeting Pten/PI3k/Akt pathway.

Zhao C, Sun W, Zhang P, Ling S, Li Y, Zhao D, Peng J, Wang A, Li Q, Song J, Wang C, Xu X, Xu Z, Zhong G, Han B, Chang YZ, Li Y.

RNA Biol. 2015;12(3):343-53. doi: 10.1080/15476286.2015.1017205.


Overexpression of Vα14Jα18 TCR promotes development of iNKT cells in the absence of miR-181a/b-1.

Blume J, Zur Lage S, Witzlau K, Georgiev H, Weiss S, Łyszkiewicz M, Ziȩtara N, Krueger A.

Immunol Cell Biol. 2016 Sep;94(8):741-6. doi: 10.1038/icb.2016.40. Epub 2016 May 10.


MicroRNA-181a/b-1 Is Not Required for Innate γδ NKT Effector Cell Development.

Sandrock I, Ziętara N, Łyszkiewicz M, Oberdörfer L, Witzlau K, Krueger A, Prinz I.

PLoS One. 2015 Dec 16;10(12):e0145010. doi: 10.1371/journal.pone.0145010. eCollection 2015.


Epigenetic silencing of microRNA-193a contributes to leukemogenesis in t(8;21) acute myeloid leukemia by activating the PTEN/PI3K signal pathway.

Li Y, Gao L, Luo X, Wang L, Gao X, Wang W, Sun J, Dou L, Li J, Xu C, Wang L, Zhou M, Jiang M, Zhou J, Caligiuri MA, Nervi C, Bloomfield CD, Marcucci G, Yu L.

Blood. 2013 Jan 17;121(3):499-509. doi: 10.1182/blood-2012-07-444729. Epub 2012 Dec 6.


Invariant NKT cell development and function in microRNA-223 knockout mice.

Li K, Seo KH, Gao T, Zheng Q, Qi RQ, Wang H, Weiland M, Dong Z, Mi QS, Zhou L.

Int Immunopharmacol. 2011 May;11(5):561-8. doi: 10.1016/j.intimp.2010.11.004. Epub 2010 Nov 19.


MicroRNA-21 accelerates hepatocyte proliferation in vitro via PI3K/Akt signaling by targeting PTEN.

Yan-nan B, Zhao-yan Y, Li-xi L, jiang Y, Qing-jie X, Yong Z.

Biochem Biophys Res Commun. 2014 Jan 17;443(3):802-7. doi: 10.1016/j.bbrc.2013.12.047. Epub 2013 Dec 14.


MicroRNA miR-150 is involved in Vα14 invariant NKT cell development and function.

Zheng Q, Zhou L, Mi QS.

J Immunol. 2012 Mar 1;188(5):2118-26. doi: 10.4049/jimmunol.1103342. Epub 2012 Jan 27.


Downregulated microRNA-32 expression induced by high glucose inhibits cell cycle progression via PTEN upregulation and Akt inactivation in bone marrow-derived mesenchymal stem cells.

Zhu G, Chai J, Ma L, Duan H, Zhang H.

Biochem Biophys Res Commun. 2013 Apr 19;433(4):526-31. doi: 10.1016/j.bbrc.2013.03.018. Epub 2013 Mar 21.


miR-205 targets PTEN and PHLPP2 to augment AKT signaling and drive malignant phenotypes in non-small cell lung cancer.

Cai J, Fang L, Huang Y, Li R, Yuan J, Yang Y, Zhu X, Chen B, Wu J, Li M.

Cancer Res. 2013 Sep 1;73(17):5402-15. doi: 10.1158/0008-5472.CAN-13-0297. Epub 2013 Jul 15.


MicroRNA-494 promotes cervical cancer proliferation through the regulation of PTEN.

Yang YK, Xi WY, Xi RX, Li JY, Li Q, Gao YE.

Oncol Rep. 2015 May;33(5):2393-401. doi: 10.3892/or.2015.3821. Epub 2015 Feb 26.


MiR-106b induces cell radioresistance via the PTEN/PI3K/AKT pathways and p21 in colorectal cancer.

Zheng L, Zhang Y, Liu Y, Zhou M, Lu Y, Yuan L, Zhang C, Hong M, Wang S, Li X.

J Transl Med. 2015 Aug 4;13:252. doi: 10.1186/s12967-015-0592-z.


Costimulation-dependent expression of microRNA-214 increases the ability of T cells to proliferate by targeting Pten.

Jindra PT, Bagley J, Godwin JG, Iacomini J.

J Immunol. 2010 Jul 15;185(2):990-7. doi: 10.4049/jimmunol.1000793. Epub 2010 Jun 14.


Mature miR-17-5p and passenger miR-17-3p induce hepatocellular carcinoma by targeting PTEN, GalNT7 and vimentin in different signal pathways.

Shan SW, Fang L, Shatseva T, Rutnam ZJ, Yang X, Du W, Lu WY, Xuan JW, Deng Z, Yang BB.

J Cell Sci. 2013 Mar 15;126(Pt 6):1517-30. doi: 10.1242/jcs.122895. Epub 2013 Feb 15.


MiRNA-21 reverses high glucose and high insulin induced insulin resistance in 3T3-L1 adipocytes through targeting phosphatase and tensin homologue.

Ling HY, Hu B, Hu XB, Zhong J, Feng SD, Qin L, Liu G, Wen GB, Liao DF.

Exp Clin Endocrinol Diabetes. 2012 Oct;120(9):553-9. doi: 10.1055/s-0032-1311644. Epub 2012 Sep 6.


MiR-21 regulates biological behavior through the PTEN/PI-3 K/Akt signaling pathway in human colorectal cancer cells.

Xiong B, Cheng Y, Ma L, Zhang C.

Int J Oncol. 2013 Jan;42(1):219-28. doi: 10.3892/ijo.2012.1707. Epub 2012 Nov 20.


MicroRNA-221 targeting PI3-K/Akt signaling axis induces cell proliferation and BCNU resistance in human glioblastoma.

Xie Q, Yan Y, Huang Z, Zhong X, Huang L.

Neuropathology. 2014 Oct;34(5):455-64. doi: 10.1111/neup.12129. Epub 2014 Apr 30.


MiR-499-5p Contributes to Hepatic Insulin Resistance by Suppressing PTEN.

Wang L, Zhang N, Pan HP, Wang Z, Cao ZY.

Cell Physiol Biochem. 2015;36(6):2357-65. doi: 10.1159/000430198. Epub 2015 Jul 27.

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