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Items: 1 to 20 of 247

1.

Evidence for tankyrases as antineoplastic targets in lung cancer.

Busch AM, Johnson KC, Stan RV, Sanglikar A, Ahmed Y, Dmitrovsky E, Freemantle SJ.

BMC Cancer. 2013 Apr 28;13:211. doi: 10.1186/1471-2407-13-211.

2.

Tankyrase inhibitors attenuate WNT/β-catenin signaling and inhibit growth of hepatocellular carcinoma cells.

Ma L, Wang X, Jia T, Wei W, Chua MS, So S.

Oncotarget. 2015 Sep 22;6(28):25390-401. doi: 10.18632/oncotarget.4455.

3.

Tankyrase Inhibitors Stimulate the Ability of Tankyrases to Bind Axin and Drive Assembly of β-Catenin Degradation-Competent Axin Puncta.

Martino-Echarri E, Brocardo MG, Mills KM, Henderson BR.

PLoS One. 2016 Mar 1;11(3):e0150484. doi: 10.1371/journal.pone.0150484. eCollection 2016.

4.

The Discovery and Characterization of K-756, a Novel Wnt/β-Catenin Pathway Inhibitor Targeting Tankyrase.

Okada-Iwasaki R, Takahashi Y, Watanabe Y, Ishida H, Saito J, Nakai R, Asai A.

Mol Cancer Ther. 2016 Jul;15(7):1525-34. doi: 10.1158/1535-7163.MCT-15-0938. Epub 2016 Apr 25.

5.

The Poly(ADP-ribose) Polymerase Enzyme Tankyrase Antagonizes Activity of the β-Catenin Destruction Complex through ADP-ribosylation of Axin and APC2.

Croy HE, Fuller CN, Giannotti J, Robinson P, Foley AV, Yamulla RJ, Cosgriff S, Greaves BD, von Kleeck RA, An HH, Powers CM, Tran JK, Tocker AM, Jacob KD, Davis BK, Roberts DM.

J Biol Chem. 2016 Jun 10;291(24):12747-60. doi: 10.1074/jbc.M115.705442. Epub 2016 Apr 11.

6.

E7449: A dual inhibitor of PARP1/2 and tankyrase1/2 inhibits growth of DNA repair deficient tumors and antagonizes Wnt signaling.

McGonigle S, Chen Z, Wu J, Chang P, Kolber-Simonds D, Ackermann K, Twine NC, Shie JL, Miu JT, Huang KC, Moniz GA, Nomoto K.

Oncotarget. 2015 Dec 1;6(38):41307-23. doi: 10.18632/oncotarget.5846.

7.

Disruption of Wnt/β-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells.

Kulak O, Chen H, Holohan B, Wu X, He H, Borek D, Otwinowski Z, Yamaguchi K, Garofalo LA, Ma Z, Wright W, Chen C, Shay JW, Zhang X, Lum L.

Mol Cell Biol. 2015 Jul;35(14):2425-35. doi: 10.1128/MCB.00392-15. Epub 2015 May 4.

8.

APC Mutations as a Potential Biomarker for Sensitivity to Tankyrase Inhibitors in Colorectal Cancer.

Tanaka N, Mashima T, Mizutani A, Sato A, Aoyama A, Gong B, Yoshida H, Muramatsu Y, Nakata K, Matsuura M, Katayama R, Nagayama S, Fujita N, Sugimoto Y, Seimiya H.

Mol Cancer Ther. 2017 Apr;16(4):752-762. doi: 10.1158/1535-7163.MCT-16-0578. Epub 2017 Feb 8.

PMID:
28179481
9.

Inhibition of tankyrases induces Axin stabilization and blocks Wnt signalling in breast cancer cells.

Bao R, Christova T, Song S, Angers S, Yan X, Attisano L.

PLoS One. 2012;7(11):e48670. doi: 10.1371/journal.pone.0048670. Epub 2012 Nov 7.

10.

A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice.

Waaler J, Machon O, Tumova L, Dinh H, Korinek V, Wilson SR, Paulsen JE, Pedersen NM, Eide TJ, Machonova O, Gradl D, Voronkov A, von Kries JP, Krauss S.

Cancer Res. 2012 Jun 1;72(11):2822-32. doi: 10.1158/0008-5472.CAN-11-3336. Epub 2012 Mar 22.

11.

The Anti-Tumor Activity of Succinyl Macrolactin A Is Mediated through the β-Catenin Destruction Complex via the Suppression of Tankyrase and PI3K/Akt.

Regmi SC, Park SY, Kim SJ, Banskota S, Shah S, Kim DH, Kim JA.

PLoS One. 2015 Nov 6;10(11):e0141753. doi: 10.1371/journal.pone.0141753. eCollection 2015.

12.

Tankyrase 1 inhibitior XAV939 increases chemosensitivity in colon cancer cell lines via inhibition of the Wnt signaling pathway.

Wu X, Luo F, Li J, Zhong X, Liu K.

Int J Oncol. 2016 Apr;48(4):1333-40. doi: 10.3892/ijo.2016.3360. Epub 2016 Jan 26.

13.

Structure, Dynamics, and Functionality of Tankyrase Inhibitor-Induced Degradasomes.

Thorvaldsen TE, Pedersen NM, Wenzel EM, Schultz SW, Brech A, Liestøl K, Waaler J, Krauss S, Stenmark H.

Mol Cancer Res. 2015 Nov;13(11):1487-501. doi: 10.1158/1541-7786.MCR-15-0125. Epub 2015 Jun 29.

14.

A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth.

Lau T, Chan E, Callow M, Waaler J, Boggs J, Blake RA, Magnuson S, Sambrone A, Schutten M, Firestein R, Machon O, Korinek V, Choo E, Diaz D, Merchant M, Polakis P, Holsworth DD, Krauss S, Costa M.

Cancer Res. 2013 May 15;73(10):3132-44. doi: 10.1158/0008-5472.CAN-12-4562. Epub 2013 Mar 28.

15.

Formation of Tankyrase Inhibitor-Induced Degradasomes Requires Proteasome Activity.

Pedersen NM, Thorvaldsen TE, Schultz SW, Wenzel EM, Stenmark H.

PLoS One. 2016 Aug 2;11(8):e0160507. doi: 10.1371/journal.pone.0160507. eCollection 2016.

16.

Molecular insights on TNKS1/TNKS2 and inhibitor-IWR1 interactions.

Kirubakaran P, Kothandan G, Cho SJ, Muthusamy K.

Mol Biosyst. 2014 Feb;10(2):281-93. doi: 10.1039/c3mb70305c.

PMID:
24291818
17.

Tankyrase Sterile α Motif Domain Polymerization Is Required for Its Role in Wnt Signaling.

Riccio AA, McCauley M, Langelier MF, Pascal JM.

Structure. 2016 Sep 6;24(9):1573-81. doi: 10.1016/j.str.2016.06.022. Epub 2016 Aug 4.

18.

The ADP-ribose polymerase Tankyrase regulates adult intestinal stem cell proliferation during homeostasis in Drosophila.

Wang Z, Tian A, Benchabane H, Tacchelly-Benites O, Yang E, Nojima H, Ahmed Y.

Development. 2016 May 15;143(10):1710-20. doi: 10.1242/dev.127647.

19.

Wnt/Wingless Pathway Activation Is Promoted by a Critical Threshold of Axin Maintained by the Tumor Suppressor APC and the ADP-Ribose Polymerase Tankyrase.

Wang Z, Tacchelly-Benites O, Yang E, Thorne CA, Nojima H, Lee E, Ahmed Y.

Genetics. 2016 May;203(1):269-81. doi: 10.1534/genetics.115.183244. Epub 2016 Mar 14.

20.

XAV939, a tankyrase 1 inhibitior, promotes cell apoptosis in neuroblastoma cell lines by inhibiting Wnt/β-catenin signaling pathway.

Tian XH, Hou WJ, Fang Y, Fan J, Tong H, Bai SL, Chen Q, Xu H, Li Y.

J Exp Clin Cancer Res. 2013 Dec 5;32:100. doi: 10.1186/1756-9966-32-100.

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