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Items: 1 to 20 of 176


Conserved allosteric hot spots in the transmembrane domains of cystic fibrosis transmembrane conductance regulator (CFTR) channels and multidrug resistance protein (MRP) pumps.

Wei S, Roessler BC, Chauvet S, Guo J, Hartman JL 4th, Kirk KL.

J Biol Chem. 2014 Jul 18;289(29):19942-57. doi: 10.1074/jbc.M114.562116.


ATP-independent CFTR channel gating and allosteric modulation by phosphorylation.

Wang W, Wu J, Bernard K, Li G, Wang G, Bevensee MO, Kirk KL.

Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3888-93. doi: 10.1073/pnas.0913001107.


Differential interactions of nucleotides at the two nucleotide binding domains of the cystic fibrosis transmembrane conductance regulator.

Aleksandrov L, Mengos A, Chang X, Aleksandrov A, Riordan JR.

J Biol Chem. 2001 Apr 20;276(16):12918-23.


Mechanism of G551D-CFTR (cystic fibrosis transmembrane conductance regulator) potentiation by a high affinity ATP analog.

Bompadre SG, Li M, Hwang TC.

J Biol Chem. 2008 Feb 29;283(9):5364-9. doi: 10.1074/jbc.M709417200.


The most common cystic fibrosis-associated mutation destabilizes the dimeric state of the nucleotide-binding domains of CFTR.

Jih KY, Li M, Hwang TC, Bompadre SG.

J Physiol. 2011 Jun 1;589(Pt 11):2719-31. doi: 10.1113/jphysiol.2010.202861.


Potentiation of disease-associated cystic fibrosis transmembrane conductance regulator mutants by hydrolyzable ATP analogs.

Miki H, Zhou Z, Li M, Hwang TC, Bompadre SG.

J Biol Chem. 2010 Jun 25;285(26):19967-75. doi: 10.1074/jbc.M109.092684.


Nucleotide-binding domains of cystic fibrosis transmembrane conductance regulator, an ABC transporter, catalyze adenylate kinase activity but not ATP hydrolysis.

Gross CH, Abdul-Manan N, Fulghum J, Lippke J, Liu X, Prabhakar P, Brennan D, Willis MS, Faerman C, Connelly P, Raybuck S, Moore J.

J Biol Chem. 2006 Feb 17;281(7):4058-68.


Pyrophosphate stimulates wild-type and mutant cystic fibrosis transmembrane conductance regulator Cl- channels.

Carson MR, Winter MC, Travis SM, Welsh MJ.

J Biol Chem. 1995 Sep 1;270(35):20466-72.


Stable ATP binding mediated by a partial NBD dimer of the CFTR chloride channel.

Tsai MF, Li M, Hwang TC.

J Gen Physiol. 2010 May;135(5):399-414. doi: 10.1085/jgp.201010399.

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