Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 105

1.

Maintenance of endothelial guanosine triphosphate cyclohydrolase I ameliorates diabetic nephropathy.

Kidokoro K, Satoh M, Channon KM, Yada T, Sasaki T, Kashihara N.

J Am Soc Nephrol. 2013 Jun;24(7):1139-50. doi: 10.1681/ASN.2012080783. Epub 2013 Apr 25.

2.

Proteasome-dependent degradation of guanosine 5'-triphosphate cyclohydrolase I causes tetrahydrobiopterin deficiency in diabetes mellitus.

Xu J, Wu Y, Song P, Zhang M, Wang S, Zou MH.

Circulation. 2007 Aug 21;116(8):944-53. Epub 2007 Aug 6.

3.
4.

Endothelium-specific GTP cyclohydrolase I overexpression attenuates blood pressure progression in salt-sensitive low-renin hypertension.

Du YH, Guan YY, Alp NJ, Channon KM, Chen AF.

Circulation. 2008 Feb 26;117(8):1045-54. doi: 10.1161/CIRCULATIONAHA.107.748236. Epub 2008 Feb 11.

5.

Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression.

Alp NJ, Mussa S, Khoo J, Cai S, Guzik T, Jefferson A, Goh N, Rockett KA, Channon KM.

J Clin Invest. 2003 Sep;112(5):725-35.

6.

HMG-CoA reductase inhibitor increases GTP cyclohydrolase I mRNA and tetrahydrobiopterin in vascular endothelial cells.

Hattori Y, Nakanishi N, Akimoto K, Yoshida M, Kasai K.

Arterioscler Thromb Vasc Biol. 2003 Feb 1;23(2):176-82.

7.
8.

Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: insights from cells with tet-regulated GTP cyclohydrolase I expression.

Crabtree MJ, Tatham AL, Al-Wakeel Y, Warrick N, Hale AB, Cai S, Channon KM, Alp NJ.

J Biol Chem. 2009 Jan 9;284(2):1136-44. doi: 10.1074/jbc.M805403200. Epub 2008 Nov 14.

10.

Characterization of cerebral microvasculature in transgenic mice with endothelium targeted over-expression of GTP-cyclohydrolase I.

Santhanam AV, d'Uscio LV, Katusic ZS.

Brain Res. 2015 Nov 2;1625:198-205. doi: 10.1016/j.brainres.2015.08.034. Epub 2015 Sep 3.

11.
12.

GTP cyclohydrolase I prevents diabetic-impaired endothelial progenitor cells and wound healing by suppressing oxidative stress/thrombospondin-1.

Tie L, Chen LY, Chen DD, Xie HH, Channon KM, Chen AF.

Am J Physiol Endocrinol Metab. 2014 May 15;306(10):E1120-31. doi: 10.1152/ajpendo.00696.2013. Epub 2014 Mar 18.

13.

In vivo activation of AMP-activated protein kinase attenuates diabetes-enhanced degradation of GTP cyclohydrolase I.

Wang S, Xu J, Song P, Viollet B, Zou MH.

Diabetes. 2009 Aug;58(8):1893-901. doi: 10.2337/db09-0267. Epub 2009 Jun 15.

14.

Gene transfer of human guanosine 5'-triphosphate cyclohydrolase I restores vascular tetrahydrobiopterin level and endothelial function in low renin hypertension.

Zheng JS, Yang XQ, Lookingland KJ, Fink GD, Hesslinger C, Kapatos G, Kovesdi I, Chen AF.

Circulation. 2003 Sep 9;108(10):1238-45. Epub 2003 Aug 18.

15.

Angiotensin II type 1 receptor blocker ameliorates uncoupled endothelial nitric oxide synthase in rats with experimental diabetic nephropathy.

Satoh M, Fujimoto S, Arakawa S, Yada T, Namikoshi T, Haruna Y, Horike H, Sasaki T, Kashihara N.

Nephrol Dial Transplant. 2008 Dec;23(12):3806-13. doi: 10.1093/ndt/gfn357. Epub 2008 Jul 2.

16.

Guanosine triphosphate cyclohydrolase I expression and enzymatic activity are present in caveolae of endothelial cells.

Peterson TE, d'Uscio LV, Cao S, Wang XL, Katusic ZS.

Hypertension. 2009 Feb;53(2):189-95. doi: 10.1161/HYPERTENSIONAHA.108.115709. Epub 2008 Dec 22.

17.

Hydrogen peroxide stimulates tetrahydrobiopterin synthesis through the induction of GTP-cyclohydrolase I and increases nitric oxide synthase activity in vascular endothelial cells.

Shimizu S, Shiota K, Yamamoto S, Miyasaka Y, Ishii M, Watabe T, Nishida M, Mori Y, Yamamoto T, Kiuchi Y.

Free Radic Biol Med. 2003 May 15;34(10):1343-52.

PMID:
12726922
18.

Tetrahydrobiopterin recycling, a key determinant of endothelial nitric-oxide synthase-dependent signaling pathways in cultured vascular endothelial cells.

Sugiyama T, Levy BD, Michel T.

J Biol Chem. 2009 May 8;284(19):12691-700. doi: 10.1074/jbc.M809295200. Epub 2009 Mar 12.

19.

Simvastatin ameliorates angiotensin II-induced endothelial dysfunction through restoration of Rho-BH4-eNOS-NO pathway.

Zhang Z, Wang M, Xue SJ, Liu DH, Tang YB.

Cardiovasc Drugs Ther. 2012 Feb;26(1):31-40. doi: 10.1007/s10557-011-6351-3.

PMID:
22083280
20.

Relationships between nitric oxide-mediated endothelial function, eNOS coupling and blood pressure revealed by eNOS-GTP cyclohydrolase 1 double transgenic mice.

Adlam D, Bendall JK, De Bono JP, Alp NJ, Khoo J, Nicoli T, Yokoyama M, Kawashima S, Channon KM.

Exp Physiol. 2007 Jan;92(1):119-26. Epub 2006 Sep 28.

Supplemental Content

Support Center