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Hyperhomocysteinemia induces cardiac injury by up-regulation of p53-dependent Noxa and Bax expression through the p53 DNA methylation in ApoE(-/-) mice.

Ma S, Zhang H, Sun W, Gong H, Wang Y, Ma C, Wang J, Cao C, Yang X, Tian J, Jiang Y.

Acta Biochim Biophys Sin (Shanghai). 2013 May;45(5):391-400. doi: 10.1093/abbs/gmt030.


The comprehensive effects of hyperlipidemia and hyperhomocysteinemia on pathogenesis of atherosclerosis and DNA hypomethylation in ApoE-/- mice.

Jiang Y, Zhang H, Sun T, Wang J, Sun W, Gong H, Yang B, Shi Y, Wei J.

Acta Biochim Biophys Sin (Shanghai). 2012 Oct;44(10):866-75.


Hyperhomocysteinemia-mediated DNA hypomethylation and its potential epigenetic role in rats.

Jiang Y, Sun T, Xiong J, Cao J, Li G, Wang S.

Acta Biochim Biophys Sin (Shanghai). 2007 Sep;39(9):657-67.


Homocysteine induces blood vessel global hypomethylation mediated by LOX-1.

Yang XL, Tian J, Liang Y, Ma CJ, Yang AN, Wang J, Ma SC, Cheng Y, Hua X, Jiang YD.

Genet Mol Res. 2014 May 16;13(2):3787-99. doi: 10.4238/2014.May.16.2.


p53 triggers apoptosis in oncogene-expressing fibroblasts by the induction of Noxa and mitochondrial Bax translocation.

Schuler M, Maurer U, Goldstein JC, Breitenb├╝cher F, Hoffarth S, Waterhouse NJ, Green DR.

Cell Death Differ. 2003 Apr;10(4):451-60.


[Folic acid prevents Bcl-2 hypomethylation in rats with hyperhomocysteinemia].

Cong G, Jia S, Luo C, Wang Y.

Wei Sheng Yan Jiu. 2012 Mar;41(2):268-72. Chinese.


Uteroplacental insufficiency increases apoptosis and alters p53 gene methylation in the full-term IUGR rat kidney.

Pham TD, MacLennan NK, Chiu CT, Laksana GS, Hsu JL, Lane RH.

Am J Physiol Regul Integr Comp Physiol. 2003 Nov;285(5):R962-70.


Nitric oxide inhibition of homocysteine-induced human endothelial cell apoptosis by down-regulation of p53-dependent Noxa expression through the formation of S-nitrosohomocysteine.

Lee SJ, Kim KM, Namkoong S, Kim CK, Kang YC, Lee H, Ha KS, Han JA, Chung HT, Kwon YG, Kim YM.

J Biol Chem. 2005 Feb 18;280(7):5781-8.


BCL-2, BAX and P53 expression profiles in endometrial carcinoma as studied by real-time PCR and immunohistochemistry.

Porichi O, Nikolaidou ME, Apostolaki A, Tserkezoglou A, Arnogiannaki N, Kassanos D, Margaritis L, Panotopoulou E.

Anticancer Res. 2009 Oct;29(10):3977-82.


[Cinnamaldehyde ofloxacin-3-ylhydrazone induces apoptosis of human hepatocarcinoma SMMC-7721 cells].

Ren Z, Kang YH, Shi ZY, Huang-Fu CS, Hu GQ, Liu B.

Yao Xue Xue Bao. 2010 Sep;45(9):1109-15. Chinese.


ApoE gene deficiency enhances the reduction of bone formation induced by a high-fat diet through the stimulation of p53-mediated apoptosis in osteoblastic cells.

Hirasawa H, Tanaka S, Sakai A, Tsutsui M, Shimokawa H, Miyata H, Moriwaki S, Niida S, Ito M, Nakamura T.

J Bone Miner Res. 2007 Jul;22(7):1020-30.


2-Phenylacetylenesulfonamide (PAS) induces p53-independent apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells.

Steele AJ, Prentice AG, Hoffbrand AV, Yogashangary BC, Hart SM, Lowdell MW, Samuel ER, North JM, Nacheva EP, Chanalaris A, Kottaridis P, Cwynarski K, Wickremasinghe RG.

Blood. 2009 Aug 6;114(6):1217-25. doi: 10.1182/blood-2008-11-190587.


[The effect of miR-124 on homocysteine-induced atherosclerosis via promoter region DNA methylation in ApoE(-/-) mice].

Zhao L, Jiao Y, Yang AN, Cao CJ, Kong FQ, Liu XM, Yang XL, Jiang YD.

Sheng Li Xue Bao. 2015 Apr 25;67(2):207-13. Chinese.


Angiotensin II-induced p53-dependent cardiac apoptotic cell death: its prevention by metallothionein.

Liu Q, Wang G, Zhou G, Tan Y, Wang X, Wei W, Liu L, Xue W, Feng W, Cai L.

Toxicol Lett. 2009 Dec 15;191(2-3):314-20. doi: 10.1016/j.toxlet.2009.09.015.


Hepatocyte proliferation during liver regeneration is impaired in mice with methionine diet-induced hyperhomocysteinemia.

Liu WH, Zhao YS, Gao SY, Li SD, Cao J, Zhang KQ, Zou CG.

Am J Pathol. 2010 Nov;177(5):2357-65. doi: 10.2353/ajpath.2010.091131.


Ionizing radiation induces a p53-dependent apoptotic mechanism in ARPE-19 cells.

Jiang YL, Esca├▒o MF, Sasaki R, Fujii S, Kusuhara S, Matsumoto A, Sugimura K, Negi A.

Jpn J Ophthalmol. 2004 Mar-Apr;48(2):106-14.

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