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Items: 1 to 20 of 110

1.

Inhibition of the proton-coupled folate transporter (PCFT-SLC46A1) by bicarbonate and other anions.

Zhao R, Visentin M, Suadicani SO, Goldman ID.

Mol Pharmacol. 2013 Jul;84(1):95-103. doi: 10.1124/mol.113.085605. Epub 2013 Apr 22.

2.

The functional roles of the His247 and His281 residues in folate and proton translocation mediated by the human proton-coupled folate transporter SLC46A1.

Unal ES, Zhao R, Chang MH, Fiser A, Romero MF, Goldman ID.

J Biol Chem. 2009 Jun 26;284(26):17846-57. doi: 10.1074/jbc.M109.008060. Epub 2009 Apr 23.

3.

Role of the glutamate 185 residue in proton translocation mediated by the proton-coupled folate transporter SLC46A1.

Unal ES, Zhao R, Goldman ID.

Am J Physiol Cell Physiol. 2009 Jul;297(1):C66-74. doi: 10.1152/ajpcell.00096.2009. Epub 2009 Apr 29.

4.

Functional roles of the A335 and G338 residues of the proton-coupled folate transporter (PCFT-SLC46A1) mutated in hereditary folate malabsorption.

Shin DS, Zhao R, Fiser A, Goldman DI.

Am J Physiol Cell Physiol. 2012 Oct 15;303(8):C834-42. doi: 10.1152/ajpcell.00171.2012. Epub 2012 Jul 25.

5.

Properties of the Arg376 residue of the proton-coupled folate transporter (PCFT-SLC46A1) and a glutamine mutant causing hereditary folate malabsorption.

Mahadeo K, Diop-Bove N, Shin D, Unal ES, Teo J, Zhao R, Chang MH, Fulterer A, Romero MF, Goldman ID.

Am J Physiol Cell Physiol. 2010 Nov;299(5):C1153-61. doi: 10.1152/ajpcell.00113.2010. Epub 2010 Aug 4.

6.

A role for the proton-coupled folate transporter (PCFT-SLC46A1) in folate receptor-mediated endocytosis.

Zhao R, Min SH, Wang Y, Campanella E, Low PS, Goldman ID.

J Biol Chem. 2009 Feb 13;284(7):4267-74. doi: 10.1074/jbc.M807665200. Epub 2008 Dec 11.

7.

Identification of Tyr residues that enhance folate substrate binding and constrain oscillation of the proton-coupled folate transporter (PCFT-SLC46A1).

Visentin M, Unal ES, Najmi M, Fiser A, Zhao R, Goldman ID.

Am J Physiol Cell Physiol. 2015 Apr 15;308(8):C631-41. doi: 10.1152/ajpcell.00238.2014. Epub 2015 Jan 21.

8.

Rodent intestinal folate transporters (SLC46A1): secondary structure, functional properties, and response to dietary folate restriction.

Qiu A, Min SH, Jansen M, Malhotra U, Tsai E, Cabelof DC, Matherly LH, Zhao R, Akabas MH, Goldman ID.

Am J Physiol Cell Physiol. 2007 Nov;293(5):C1669-78. Epub 2007 Sep 26.

9.

The obligatory intestinal folate transporter PCFT (SLC46A1) is regulated by nuclear respiratory factor 1.

Gonen N, Assaraf YG.

J Biol Chem. 2010 Oct 29;285(44):33602-13. doi: 10.1074/jbc.M110.135640. Epub 2010 Aug 19.

10.

Role of the tryptophan residues in proton-coupled folate transporter (PCFT-SLC46A1) function.

Najmi M, Zhao R, Fiser A, Goldman ID.

Am J Physiol Cell Physiol. 2016 Jul 1;311(1):C150-7. doi: 10.1152/ajpcell.00084.2016. Epub 2016 Jun 1.

11.

Identification and functional impact of homo-oligomers of the human proton-coupled folate transporter.

Hou Z, Kugel Desmoulin S, Etnyre E, Olive M, Hsiung B, Cherian C, Wloszczynski PA, Moin K, Matherly LH.

J Biol Chem. 2012 Feb 10;287(7):4982-95. doi: 10.1074/jbc.M111.306860. Epub 2011 Dec 16.

12.

The proton-coupled folate transporter: impact on pemetrexed transport and on antifolates activities compared with the reduced folate carrier.

Zhao R, Qiu A, Tsai E, Jansen M, Akabas MH, Goldman ID.

Mol Pharmacol. 2008 Sep;74(3):854-62. doi: 10.1124/mol.108.045443. Epub 2008 Jun 4.

13.

Identification of a functionally critical GXXG motif and its relationship to the folate binding site of the proton-coupled folate transporter (PCFT-SLC46A1).

Zhao R, Shin DS, Fiser A, Goldman ID.

Am J Physiol Cell Physiol. 2012 Sep 15;303(6):C673-81. doi: 10.1152/ajpcell.00123.2012. Epub 2012 Jul 11.

14.

Methotrexate influx via folate transporters into alveolar epithelial cell line A549.

Kawami M, Miyamoto M, Yumoto R, Takano M.

Drug Metab Pharmacokinet. 2015 Aug;30(4):276-81. doi: 10.1016/j.dmpk.2015.04.005. Epub 2015 May 16.

PMID:
26190800
15.

Hypermethylation of the human proton-coupled folate transporter (SLC46A1) minimal transcriptional regulatory region in an antifolate-resistant HeLa cell line.

Diop-Bove NK, Wu J, Zhao R, Locker J, Goldman ID.

Mol Cancer Ther. 2009 Aug;8(8):2424-31. doi: 10.1158/1535-7163.MCT-08-0938. Epub 2009 Aug 11.

16.

Biology of the major facilitative folate transporters SLC19A1 and SLC46A1.

Hou Z, Matherly LH.

Curr Top Membr. 2014;73:175-204. doi: 10.1016/B978-0-12-800223-0.00004-9. Review.

17.

The monomeric state of the proton-coupled folate transporter represents the functional unit in the plasma membrane.

Duddempudi PK, Nakashe P, Blanton MP, Jansen M.

FEBS J. 2013 Jun;280(12):2900-15. doi: 10.1111/febs.12293. Epub 2013 May 28.

18.

A P425R mutation of the proton-coupled folate transporter causing hereditary folate malabsorption produces a highly selective alteration in folate binding.

Shin DS, Zhao R, Yap EH, Fiser A, Goldman ID.

Am J Physiol Cell Physiol. 2012 May 1;302(9):C1405-12. doi: 10.1152/ajpcell.00435.2011. Epub 2012 Feb 15.

19.

Functional roles of aspartate residues of the proton-coupled folate transporter (PCFT-SLC46A1); a D156Y mutation causing hereditary folate malabsorption.

Shin DS, Min SH, Russell L, Zhao R, Fiser A, Goldman ID.

Blood. 2010 Dec 9;116(24):5162-9. doi: 10.1182/blood-2010-06-291237. Epub 2010 Aug 30.

20.

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