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Items: 1 to 20 of 118

1.

MicroRNA-210 decreases heme levels by targeting ferrochelatase in cardiomyocytes.

Qiao A, Khechaduri A, Kannan Mutharasan R, Wu R, Nagpal V, Ardehali H.

J Am Heart Assoc. 2013 Apr 22;2(2):e000121. doi: 10.1161/JAHA.113.000121.

2.

Posttranslational stability of the heme biosynthetic enzyme ferrochelatase is dependent on iron availability and intact iron-sulfur cluster assembly machinery.

Crooks DR, Ghosh MC, Haller RG, Tong WH, Rouault TA.

Blood. 2010 Jan 28;115(4):860-9. doi: 10.1182/blood-2009-09-243105. Epub 2009 Nov 25.

3.

Regulation of ferrochelatase gene expression by hypoxia.

Liu YL, Ang SO, Weigent DA, Prchal JT, Bloomer JR.

Life Sci. 2004 Sep 10;75(17):2035-43.

PMID:
15312748
4.

The heme synthesis defect of mutants impaired in mitochondrial iron-sulfur protein biogenesis is caused by reversible inhibition of ferrochelatase.

Lange H, Mühlenhoff U, Denzel M, Kispal G, Lill R.

J Biol Chem. 2004 Jul 9;279(28):29101-8. Epub 2004 May 5.

5.

MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2.

Chan SY, Zhang YY, Hemann C, Mahoney CE, Zweier JL, Loscalzo J.

Cell Metab. 2009 Oct;10(4):273-84. doi: 10.1016/j.cmet.2009.08.015.

6.

microRNA-210 is upregulated in hypoxic cardiomyocytes through Akt- and p53-dependent pathways and exerts cytoprotective effects.

Mutharasan RK, Nagpal V, Ichikawa Y, Ardehali H.

Am J Physiol Heart Circ Physiol. 2011 Oct;301(4):H1519-30. doi: 10.1152/ajpheart.01080.2010. Epub 2011 Aug 12.

7.

MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU.

Favaro E, Ramachandran A, McCormick R, Gee H, Blancher C, Crosby M, Devlin C, Blick C, Buffa F, Li JL, Vojnovic B, Pires das Neves R, Glazer P, Iborra F, Ivan M, Ragoussis J, Harris AL.

PLoS One. 2010 Apr 26;5(4):e10345. doi: 10.1371/journal.pone.0010345.

8.

Ferrochelatase forms an oligomeric complex with mitoferrin-1 and Abcb10 for erythroid heme biosynthesis.

Chen W, Dailey HA, Paw BH.

Blood. 2010 Jul 29;116(4):628-30. doi: 10.1182/blood-2009-12-259614. Epub 2010 Apr 28.

9.

MiRNA-210 modulates a nickel-induced cellular energy metabolism shift by repressing the iron-sulfur cluster assembly proteins ISCU1/2 in Neuro-2a cells.

He M, Lu Y, Xu S, Mao L, Zhang L, Duan W, Liu C, Pi H, Zhang Y, Zhong M, Yu Z, Zhou Z.

Cell Death Dis. 2014 Feb 27;5:e1090. doi: 10.1038/cddis.2014.60.

10.

Heme biosynthesis modulation via δ-aminolevulinic acid administration attenuates chronic hypoxia-induced pulmonary hypertension.

Alhawaj R, Patel D, Kelly MR, Sun D, Wolin MS.

Am J Physiol Lung Cell Mol Physiol. 2015 Apr 1;308(7):L719-28. doi: 10.1152/ajplung.00155.2014. Epub 2015 Feb 6.

11.

Involvement of ABC7 in the biosynthesis of heme in erythroid cells: interaction of ABC7 with ferrochelatase.

Taketani S, Kakimoto K, Ueta H, Masaki R, Furukawa T.

Blood. 2003 Apr 15;101(8):3274-80. Epub 2002 Dec 12.

12.

Overexpression of the yeast frataxin homolog (Yfh1): contrasting effects on iron-sulfur cluster assembly, heme synthesis and resistance to oxidative stress.

Seguin A, Bayot A, Dancis A, Rogowska-Wrzesinska A, Auchère F, Camadro JM, Bulteau AL, Lesuisse E.

Mitochondrion. 2009 Apr;9(2):130-8. doi: 10.1016/j.mito.2009.01.007. Epub 2009 Jan 22.

PMID:
19460301
13.

Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension.

White K, Lu Y, Annis S, Hale AE, Chau BN, Dahlman JE, Hemann C, Opotowsky AR, Vargas SO, Rosas I, Perrella MA, Osorio JC, Haley KJ, Graham BB, Kumar R, Saggar R, Saggar R, Wallace WD, Ross DJ, Khan OF, Bader A, Gochuico BR, Matar M, Polach K, Johannessen NM, Prosser HM, Anderson DG, Langer R, Zweier JL, Bindoff LA, Systrom D, Waxman AB, Jin RC, Chan SY.

EMBO Mol Med. 2015 Jun;7(6):695-713. doi: 10.15252/emmm.201404511.

14.

Frataxin-mediated iron delivery to ferrochelatase in the final step of heme biosynthesis.

Yoon T, Cowan JA.

J Biol Chem. 2004 Jun 18;279(25):25943-6. Epub 2004 Apr 27.

15.

Salicylic acid induces mitochondrial injury by inhibiting ferrochelatase heme biosynthesis activity.

Gupta V, Liu S, Ando H, Ishii R, Tateno S, Kaneko Y, Yugami M, Sakamoto S, Yamaguchi Y, Nureki O, Handa H.

Mol Pharmacol. 2013 Dec;84(6):824-33. doi: 10.1124/mol.113.087940. Epub 2013 Sep 16.

16.

Hypoxia-regulated microRNA-210 modulates mitochondrial function and decreases ISCU and COX10 expression.

Chen Z, Li Y, Zhang H, Huang P, Luthra R.

Oncogene. 2010 Jul 29;29(30):4362-8. doi: 10.1038/onc.2010.193. Epub 2010 May 24.

PMID:
20498629
17.

MicroRNA-15b modulates cellular ATP levels and degenerates mitochondria via Arl2 in neonatal rat cardiac myocytes.

Nishi H, Ono K, Iwanaga Y, Horie T, Nagao K, Takemura G, Kinoshita M, Kuwabara Y, Mori RT, Hasegawa K, Kita T, Kimura T.

J Biol Chem. 2010 Feb 12;285(7):4920-30. doi: 10.1074/jbc.M109.082610. Epub 2009 Dec 10.

18.

The Structure of the Complex between Yeast Frataxin and Ferrochelatase: CHARACTERIZATION AND PRE-STEADY STATE REACTION OF FERROUS IRON DELIVERY AND HEME SYNTHESIS.

Söderberg C, Gillam ME, Ahlgren EC, Hunter GA, Gakh O, Isaya G, Ferreira GC, Al-Karadaghi S.

J Biol Chem. 2016 May 27;291(22):11887-98. doi: 10.1074/jbc.M115.701128. Epub 2016 Mar 29.

19.

Micromanaging Iron Homeostasis: hypoxia-inducible micro-RNA-210 suppresses iron homeostasis-related proteins.

Yoshioka Y, Kosaka N, Ochiya T, Kato T.

J Biol Chem. 2012 Oct 5;287(41):34110-9. doi: 10.1074/jbc.M112.356717. Epub 2012 Aug 15.

20.

Heme levels are increased in human failing hearts.

Khechaduri A, Bayeva M, Chang HC, Ardehali H.

J Am Coll Cardiol. 2013 May 7;61(18):1884-93. doi: 10.1016/j.jacc.2013.02.012. Epub 2013 Mar 6.

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