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Items: 1 to 20 of 92

1.

Systems-wide analysis of K-Ras, Cdc42, and PAK4 signaling by quantitative phosphoproteomics.

Gnad F, Young A, Zhou W, Lyle K, Ong CC, Stokes MP, Silva JC, Belvin M, Friedman LS, Koeppen H, Minden A, Hoeflich KP.

Mol Cell Proteomics. 2013 Aug;12(8):2070-80. doi: 10.1074/mcp.M112.027052. Epub 2013 Apr 22.

2.

Cdc42- and Rac1-mediated endothelial lumen formation requires Pak2, Pak4 and Par3, and PKC-dependent signaling.

Koh W, Mahan RD, Davis GE.

J Cell Sci. 2008 Apr 1;121(Pt 7):989-1001. doi: 10.1242/jcs.020693. Epub 2008 Mar 4.

3.

Compartmentalized Ras proteins transform NIH 3T3 cells with different efficiencies.

Cheng CM, Li H, Gasman S, Huang J, Schiff R, Chang EC.

Mol Cell Biol. 2011 Mar;31(5):983-97. doi: 10.1128/MCB.00137-10. Epub 2010 Dec 28.

4.
5.

Functional cross-talk between Cdc42 and two downstream targets, Par6B and PAK4.

Jin D, Durgan J, Hall A.

Biochem J. 2015 Apr 15;467(2):293-302. doi: 10.1042/BJ20141352.

PMID:
25662318
6.

Group I and II mammalian PAKs have different modes of activation by Cdc42.

Baskaran Y, Ng YW, Selamat W, Ling FT, Manser E.

EMBO Rep. 2012 Jun 29;13(7):653-9. doi: 10.1038/embor.2012.75.

7.

PAK4 kinase-mediated SCG10 phosphorylation involved in gastric cancer metastasis.

Guo Q, Su N, Zhang J, Li X, Miao Z, Wang G, Cheng M, Xu H, Cao L, Li F.

Oncogene. 2014 Jun 19;33(25):3277-87. doi: 10.1038/onc.2013.296. Epub 2013 Jul 29.

PMID:
23893240
8.
9.

The Cdc42 Effector Kinase PAK4 Localizes to Cell-Cell Junctions and Contributes to Establishing Cell Polarity.

Selamat W, Tay PL, Baskaran Y, Manser E.

PLoS One. 2015 Jun 11;10(6):e0129634. doi: 10.1371/journal.pone.0129634. eCollection 2015.

10.

Functional phosphoproteomics of oncogenic KRAS signaling.

Sudhir PR, Chen JY.

Methods Mol Biol. 2014;1120:157-66. doi: 10.1007/978-1-62703-791-4_10.

PMID:
24470024
11.

The pak4 protein kinase plays a key role in cell survival and tumorigenesis in athymic mice.

Liu Y, Xiao H, Tian Y, Nekrasova T, Hao X, Lee HJ, Suh N, Yang CS, Minden A.

Mol Cancer Res. 2008 Jul;6(7):1215-24. doi: 10.1158/1541-7786.MCR-08-0087.

12.

Phosphoproteomics identifies oncogenic Ras signaling targets and their involvement in lung adenocarcinomas.

Sudhir PR, Hsu CL, Wang MJ, Wang YT, Chen YJ, Sung TY, Hsu WL, Yang UC, Chen JY.

PLoS One. 2011;6(5):e20199. doi: 10.1371/journal.pone.0020199. Epub 2011 May 26.

13.

Knockdown of PAK4 or PAK1 inhibits the proliferation of mutant KRAS colon cancer cells independently of RAF/MEK/ERK and PI3K/AKT signaling.

Tabusa H, Brooks T, Massey AJ.

Mol Cancer Res. 2013 Feb;11(2):109-21. doi: 10.1158/1541-7786.MCR-12-0466. Epub 2012 Dec 10.

14.

PAK4 kinase activity and somatic mutation promote carcinoma cell motility and influence inhibitor sensitivity.

Whale AD, Dart A, Holt M, Jones GE, Wells CM.

Oncogene. 2013 Apr 18;32(16):2114-20. doi: 10.1038/onc.2012.233. Epub 2012 Jun 11.

15.

Chronic Cigarette Smoke Mediated Global Changes in Lung Mucoepidermoid Cells: A Phosphoproteomic Analysis.

Solanki HS, Advani J, Khan AA, Radhakrishnan A, Sahasrabuddhe NA, Pinto SM, Chang X, Prasad TSK, Mathur PP, Sidransky D, Gowda H, Chatterjee A.

OMICS. 2017 Aug;21(8):474-487. doi: 10.1089/omi.2017.0090.

PMID:
28816646
16.

Formation of endothelial lumens requires a coordinated PKCepsilon-, Src-, Pak- and Raf-kinase-dependent signaling cascade downstream of Cdc42 activation.

Koh W, Sachidanandam K, Stratman AN, Sacharidou A, Mayo AM, Murphy EA, Cheresh DA, Davis GE.

J Cell Sci. 2009 Jun 1;122(Pt 11):1812-22. doi: 10.1242/jcs.045799. Epub 2009 May 12.

17.

Cdc42 regulates apical junction formation in human bronchial epithelial cells through PAK4 and Par6B.

Wallace SW, Durgan J, Jin D, Hall A.

Mol Biol Cell. 2010 Sep 1;21(17):2996-3006. doi: 10.1091/mbc.E10-05-0429. Epub 2010 Jul 14.

18.

PAK4 is required for regulation of the cell-cycle regulatory protein p21, and for control of cell-cycle progression.

Nekrasova T, Minden A.

J Cell Biochem. 2011 Jul;112(7):1795-806. doi: 10.1002/jcb.23092.

PMID:
21381077
19.
20.

The rho guanosine 5'-triphosphatase, cell division cycle 42, is required for insulin-induced actin remodeling and glucagon-like peptide-1 secretion in the intestinal endocrine L cell.

Lim GE, Xu M, Sun J, Jin T, Brubaker PL.

Endocrinology. 2009 Dec;150(12):5249-61. doi: 10.1210/en.2009-0508. Epub 2009 Oct 9.

PMID:
19819966

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