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Indole-3-carbinol inhibits cell proliferation and induces apoptosis in Hep-2 laryngeal cancer cells.

Wang YQ, Chen C, Chen Z, Xu Y, Wang Y, Xiao BK, Chen SM, Tao ZZ.

Oncol Rep. 2013 Jul;30(1):227-33. doi: 10.3892/or.2013.2411. Epub 2013 Apr 22.


Akt inactivation is a key event in indole-3-carbinol-induced apoptosis in PC-3 cells.

Chinni SR, Sarkar FH.

Clin Cancer Res. 2002 Apr;8(4):1228-36.


Indole-3-carbinol inhibits nasopharyngeal carcinoma cell growth in vivo and in vitro through inhibition of the PI3K/Akt pathway.

Mao CG, Tao ZZ, Chen Z, Chen C, Chen SM, Wan LJ.

Exp Ther Med. 2014 Jul;8(1):207-212. Epub 2014 Apr 25.


Indole-3-carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest and apoptosis in prostate cancer cells.

Chinni SR, Li Y, Upadhyay S, Koppolu PK, Sarkar FH.

Oncogene. 2001 May 24;20(23):2927-36.


Anti-proliferative and pro-apoptotic effects of 3,3'-diindolylmethane in human cervical cancer cells.

Zhu J, Li Y, Guan C, Chen Z.

Oncol Rep. 2012 Sep;28(3):1063-8. doi: 10.3892/or.2012.1877. Epub 2012 Jun 20.


3,3'-Diindolylmethane downregulates pro-survival pathway in hormone independent prostate cancer.

Garikapaty VP, Ashok BT, Tadi K, Mittelman A, Tiwari RK.

Biochem Biophys Res Commun. 2006 Feb 10;340(2):718-25. Epub 2005 Dec 20.


Indole-3-carbinol (I3C) exhibits inhibitory and preventive effects on prostate tumors in mice.

Souli E, Machluf M, Morgenstern A, Sabo E, Yannai S.

Food Chem Toxicol. 2008 Mar;46(3):863-70. Epub 2007 Oct 30.


SB365 inhibits angiogenesis and induces apoptosis of hepatocellular carcinoma through modulation of PI3K/Akt/mTOR signaling pathway.

Hong SW, Jung KH, Lee HS, Choi MJ, Son MK, Zheng HM, Hong SS.

Cancer Sci. 2012 Nov;103(11):1929-37. doi: 10.1111/j.1349-7006.2012.02409.x. Epub 2012 Sep 25. Erratum in: Cancer Sci. 2013 Oct;104(10):1389.


S9, a novel anticancer agent, exerts its anti-proliferative activity by interfering with both PI3K-Akt-mTOR signaling and microtubule cytoskeleton.

Zhang C, Yang N, Yang CH, Ding HS, Luo C, Zhang Y, Wu MJ, Zhang XW, Shen X, Jiang HL, Meng LH, Ding J.

PLoS One. 2009;4(3):e4881. doi: 10.1371/journal.pone.0004881. Epub 2009 Mar 18.


Translocation of Bax to mitochondria induces apoptotic cell death in indole-3-carbinol (I3C) treated breast cancer cells.

Rahman KM, Aranha O, Glazyrin A, Chinni SR, Sarkar FH.

Oncogene. 2000 Nov 23;19(50):5764-71.


HS-116, a novel phosphatidylinositol 3-kinase inhibitor induces apoptosis and suppresses angiogenesis of hepatocellular carcinoma through inhibition of the PI3K/AKT/mTOR pathway.

Jung KH, Choi MJ, Hong S, Lee H, Hong SW, Zheng HM, Lee HS, Hong S, Hong SS.

Cancer Lett. 2012 Mar 28;316(2):187-95. doi: 10.1016/j.canlet.2011.10.037. Epub 2011 Nov 4.


In vivo and in vitro study on the role of 3,3'-diindolylmethane in treatment and prevention of nasopharyngeal carcinoma.

Chen C, Chen SM, Xu B, Chen Z, Wang F, Ren J, Xu Y, Wang Y, Xiao BK, Tao ZZ.

Carcinogenesis. 2013 Aug;34(8):1815-21. doi: 10.1093/carcin/bgt122. Epub 2013 Apr 8.


(3-Chloroacetyl)-indole, a novel allosteric AKT inhibitor, suppresses colon cancer growth in vitro and in vivo.

Kim DJ, Reddy K, Kim MO, Li Y, Nadas J, Cho YY, Kim JE, Shim JH, Song NR, Carper A, Lubet RA, Bode AM, Dong Z.

Cancer Prev Res (Phila). 2011 Nov;4(11):1842-51. doi: 10.1158/1940-6207.CAPR-11-0158. Epub 2011 Sep 1.


KRC-408, a novel c-Met inhibitor, suppresses cell proliferation and angiogenesis of gastric cancer.

Hong SW, Jung KH, Park BH, Zheng HM, Lee HS, Choi MJ, Yun JI, Kang NS, Lee J, Hong SS.

Cancer Lett. 2013 May 10;332(1):74-82. doi: 10.1016/j.canlet.2013.01.015. Epub 2013 Jan 21.


[Effects of deguelin on proliferation and apoptosis of MCF-7 breast cancer cells by phosphatidylinositol 3-kinase/Akt signaling pathway].

Chu ZH, Liang XH, Zhou XL, Huang RF, Zhan Qz, Jiang JW.

Zhong Xi Yi Jie He Xue Bao. 2011 May;9(5):533-8. Chinese.


Targeted inhibition of phosphatidyl inositol-3-kinase p110β, but not p110α, enhances apoptosis and sensitivity to paclitaxel in chemoresistant ovarian cancers.

Jeong JY, Kim KS, Moon JS, Song JA, Choi SH, Kim KI, Kim TH, An HJ.

Apoptosis. 2013 Apr;18(4):509-20. doi: 10.1007/s10495-013-0807-9.


In vitro suppression of growth of murine WEHI-3 leukemia cells and in vivo promotion of phagocytosis in a leukemia mice model by indole-3-carbinol.

Lu HF, Tung WL, Yang JS, Huang FM, Lee CS, Huang YP, Liao WY, Chen YL, Chung JG.

J Agric Food Chem. 2012 Aug 8;60(31):7634-43. doi: 10.1021/jf300963t. Epub 2012 Jul 26.


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