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Items: 1 to 20 of 115


Withaferin A induces apoptosis by activating p38 mitogen-activated protein kinase signaling cascade in leukemic cells of lymphoid and myeloid origin through mitochondrial death cascade.

Mandal C, Dutta A, Mallick A, Chandra S, Misra L, Sangwan RS, Mandal C.

Apoptosis. 2008 Dec;13(12):1450-64. doi: 10.1007/s10495-008-0271-0.


Reactive oxygen species-mediated mitochondrial pathway is involved in Baohuoside I-induced apoptosis in human non-small cell lung cancer.

Song J, Shu L, Zhang Z, Tan X, Sun E, Jin X, Chen Y, Jia X.

Chem Biol Interact. 2012 Jul 30;199(1):9-17. doi: 10.1016/j.cbi.2012.05.005. Epub 2012 Jun 9.


Genipin induced apoptosis associated with activation of the c-Jun NH2-terminal kinase and p53 protein in HeLa cells.

Cao H, Feng Q, Xu W, Li X, Kang Z, Ren Y, Du L.

Biol Pharm Bull. 2010;33(8):1343-8.


Subamolide A, a component isolated from Cinnamomum subavenium, induces apoptosis mediated by mitochondria-dependent, p53 and ERK1/2 pathways in human urothelial carcinoma cell line NTUB1.

Liu CH, Chen CY, Huang AM, Li JH.

J Ethnopharmacol. 2011 Sep 1;137(1):503-11. doi: 10.1016/j.jep.2011.06.001. Epub 2011 Jun 17.


Curcumin induces mitochondria pathway mediated cell apoptosis in A549 lung adenocarcinoma cells.

Chen QY, Lu GH, Wu YQ, Zheng Y, Xu K, Wu LJ, Jiang ZY, Feng R, Zhou JY.

Oncol Rep. 2010 May;23(5):1285-92.


Ursolic acid induces apoptosis through mitochondrial intrinsic pathway and suppression of ERK1/2 MAPK in HeLa cells.

Li Y, Lu X, Qi H, Li X, Xiao X, Gao J.

J Pharmacol Sci. 2014;125(2):202-10. Epub 2014 May 30.


Induction of p53 contributes to apoptosis of HCT-116 human colon cancer cells induced by the dietary compound fisetin.

Lim DY, Park JH.

Am J Physiol Gastrointest Liver Physiol. 2009 May;296(5):G1060-8. doi: 10.1152/ajpgi.90490.2008. Epub 2009 Mar 5.


A novel synthetic analog of Militarin, MA-1 induces mitochondrial dependent apoptosis by ROS generation in human lung cancer cells.

Yoon DH, Lim MH, Lee YR, Sung GH, Lee TH, Jeon BH, Cho JY, Song WO, Park H, Choi S, Kim TW.

Toxicol Appl Pharmacol. 2013 Dec 15;273(3):659-71. doi: 10.1016/j.taap.2013.10.015. Epub 2013 Oct 22.


Activation of Bak and Bax through c-abl-protein kinase Cdelta-p38 MAPK signaling in response to ionizing radiation in human non-small cell lung cancer cells.

Choi SY, Kim MJ, Kang CM, Bae S, Cho CK, Soh JW, Kim JH, Kang S, Chung HY, Lee YS, Lee SJ.

J Biol Chem. 2006 Mar 17;281(11):7049-59. Epub 2006 Jan 12.


Gambogenic acid induced mitochondrial-dependent apoptosis and referred to phospho-Erk1/2 and phospho-p38 MAPK in human hepatoma HepG2 cells.

Yan F, Wang M, Li J, Cheng H, Su J, Wang X, Wu H, Xia L, Li X, Chang HC, Li Q.

Environ Toxicol Pharmacol. 2012 Mar;33(2):181-90. doi: 10.1016/j.etap.2011.12.006. Epub 2011 Dec 10.


Celastrol induces apoptosis in non-small-cell lung cancer A549 cells through activation of mitochondria- and Fas/FasL-mediated pathways.

Mou H, Zheng Y, Zhao P, Bao H, Fang W, Xu N.

Toxicol In Vitro. 2011 Aug;25(5):1027-32. doi: 10.1016/j.tiv.2011.03.023. Epub 2011 Apr 3.


Genipin-induced apoptosis in hepatoma cells is mediated by reactive oxygen species/c-Jun NH2-terminal kinase-dependent activation of mitochondrial pathway.

Kim BC, Kim HG, Lee SA, Lim S, Park EH, Kim SJ, Lim CJ.

Biochem Pharmacol. 2005 Nov 1;70(9):1398-407.


Suppression of extracellular signal-related kinase and activation of p38 MAPK are two critical events leading to caspase-8- and mitochondria-mediated cell death in phytosphingosine-treated human cancer cells.

Park MT, Choi JA, Kim MJ, Um HD, Bae S, Kang CM, Cho CK, Kang S, Chung HY, Lee YS, Lee SJ.

J Biol Chem. 2003 Dec 12;278(50):50624-34. Epub 2003 Sep 30.


Induction of apoptosis by fucoidan in human leukemia U937 cells through activation of p38 MAPK and modulation of Bcl-2 family.

Park HS, Hwang HJ, Kim GY, Cha HJ, Kim WJ, Kim ND, Yoo YH, Choi YH.

Mar Drugs. 2013 Jul 4;11(7):2347-64. doi: 10.3390/md11072347.


Magnolol-induced apoptosis in HCT-116 colon cancer cells is associated with the AMP-activated protein kinase signaling pathway.

Park JB, Lee MS, Cha EY, Lee JS, Sul JY, Song IS, Kim JY.

Biol Pharm Bull. 2012;35(9):1614-20.


Apoptosis inducing activity of fucoidan in HCT-15 colon carcinoma cells.

Hyun JH, Kim SC, Kang JI, Kim MK, Boo HJ, Kwon JM, Koh YS, Hyun JW, Park DB, Yoo ES, Kang HK.

Biol Pharm Bull. 2009 Oct;32(10):1760-4.


Casticin induces caspase-mediated apoptosis via activation of mitochondrial pathway and upregulation of DR5 in human lung cancer cells.

Zhou Y, Peng Y, Mao QQ, Li X, Chen MW, Su J, Tian L, Mao NQ, Long LZ, Quan MF, Liu F, Zhou SF, Zhao YX.

Asian Pac J Trop Med. 2013 May 13;6(5):372-8. doi: 10.1016/S1995-7645(13)60041-3.

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