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Items: 1 to 20 of 101

1.

Effect of MB327 and oximes on rat intestinal smooth muscle function.

Königer C, Worek F, Thiermann H, Wille T.

Chem Biol Interact. 2013 Jun 25;204(1):1-5. doi: 10.1016/j.cbi.2013.04.004. Epub 2013 Apr 18.

PMID:
23603452
2.

Restoration of soman-blocked neuromuscular transmission in human and rat muscle by the bispyridinium non-oxime MB327 in vitro.

Seeger T, Eichhorn M, Lindner M, Niessen KV, Tattersall JE, Timperley CM, Bird M, Green AC, Thiermann H, Worek F.

Toxicology. 2012 Apr 11;294(2-3):80-4. doi: 10.1016/j.tox.2012.02.002. Epub 2012 Feb 13.

PMID:
22349640
3.

Bispyridinium non-oximes: An evaluation of cardiac effects in isolated hearts and smooth muscle relaxing effects in jejunum.

Neumaier K, Worek F, Thiermann H, Wille T.

Toxicol In Vitro. 2016 Sep;35:11-6. doi: 10.1016/j.tiv.2016.05.005. Epub 2016 May 13.

PMID:
27184650
4.

Pharmacokinetic profile and quantitation of protection against soman poisoning by the antinicotinic compound MB327 in the guinea-pig.

Price ME, Docx CJ, Rice H, Fairhall SJ, Poole SJ, Bird M, Whiley L, Flint DP, Green AC, Timperley CM, Tattersall JE.

Toxicol Lett. 2016 Feb 26;244:154-60. doi: 10.1016/j.toxlet.2015.08.013. Epub 2015 Sep 19.

PMID:
26325216
5.

Evaluation of the benefit of the bispyridinium compound MB327 for the antidotal treatment of nerve agent-poisoned mice.

Kassa J, Pohanka M, Timperley CM, Bird M, Green AC, Tattersall JE.

Toxicol Mech Methods. 2016 Jun;26(5):334-9. doi: 10.3109/15376516.2016.1162249. Epub 2016 Apr 20.

PMID:
27097774
6.

Interaction of pyridinium oximes with acetylcholinesterase and their effect on organophosphate-poisoned mice.

Kovarik Z, Calić M, Vrdoljak AL, Radić B.

J Mol Neurosci. 2006;30(1-2):113-4.

PMID:
17192653
7.

The efficacy of some bis-pyridinium oximes as antidotes to soman in isolated muscles of several species including man.

Wolthuis O, Vanwersch RA, Van der Wiel HJ.

Eur J Pharmacol. 1981 Mar 26;70(3):355-69.

PMID:
6262098
8.
10.
11.

A comparison of the reactivating and therapeutic efficacy of newly developed bispyridinium oximes (K250, K251) with commonly used oximes against tabun in rats and mice.

Kassa J, Karasova J, Bajgar J, Kuca K, Musilek K, Kopelikova I.

J Enzyme Inhib Med Chem. 2009 Aug;24(4):1040-4. doi: 10.1080/14756360802608419.

PMID:
19552519
12.
13.

A comparison of reactivating and therapeutic efficacy of bispyridinium acetylcholinesterase reactivator KR-22934 with the oxime K203 and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice.

Kassa J, Karasova JZ, Pavlikova R, Musilek K, Kuca K, Bajgar J, Jung YS.

Toxicol Mech Methods. 2011 Mar;21(3):241-5. doi: 10.3109/15376516.2010.538750. Epub 2010 Dec 10.

PMID:
21142778
15.

Kinetic studies and structure-activity relationships of bispyridinium oximes as reactivators of acetylcholinesterase inhibited by organophosphorus compounds.

Su CT, Wang PH, Liu RF, Shih JH, Ma C, Lin CH, Liu CY, Wu MT.

Fundam Appl Toxicol. 1986 Apr;6(3):506-14.

PMID:
3699334
16.
17.

Bispyridinium oximes as antidotal treatment of cyclosarin poisoning-in vitro and in vivo testing.

Bartosova L, Kuca K, Jun D, Kunesova G.

Int J Toxicol. 2005 Nov-Dec;24(6):399-402.

PMID:
16393932
19.

Reactivation kinetics of a homologous series of bispyridinium bis-oximes with nerve agent-inhibited human acetylcholinesterase.

Worek F, von der Wellen J, Musilek K, Kuca K, Thiermann H.

Arch Toxicol. 2012 Sep;86(9):1379-86. doi: 10.1007/s00204-012-0842-2. Epub 2012 Mar 22.

PMID:
22437842
20.

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