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Bone marrow lesions identified by MRI in knee osteoarthritis are associated with locally increased bone mineral density measured by QCT.

Lowitz T, Museyko O, Bousson V, Laouisset L, Kalender WA, Laredo JD, Engelke K.

Osteoarthritis Cartilage. 2013 Jul;21(7):957-64. doi: 10.1016/j.joca.2013.04.006. Epub 2013 Apr 18.


Bone marrow lesions in the knee are associated with increased local bone density.

Lo GH, Hunter DJ, Zhang Y, McLennan CE, Lavalley MP, Kiel DP, McLean RR, Genant HK, Guermazi A, Felson DT.

Arthritis Rheum. 2005 Sep;52(9):2814-21.


The association between hip bone marrow lesions and bone mineral density: a cross-sectional and longitudinal population-based study.

Ahedi H, Aitken D, Blizzard L, Cicuttini F, Jones G.

Osteoarthritis Cartilage. 2013 Oct;21(10):1545-9. doi: 10.1016/j.joca.2013.06.002. Epub 2013 Jun 19.


Bone marrow lesion volume reduction is not associated with improvement of other periarticular bone measures: data from the Osteoarthritis Initiative.

Driban JB, Lo GH, Price L, Pang J, Miller E, Ward RJ, Hunter DJ, Eaton CB, Lynch JA, McAlindon TE; OAI Investigators Group.

Arthritis Res Ther. 2013;15(5):R153.


Correlation of the development of knee pain with enlarging bone marrow lesions on magnetic resonance imaging.

Felson DT, Niu J, Guermazi A, Roemer F, Aliabadi P, Clancy M, Torner J, Lewis CE, Nevitt MC.

Arthritis Rheum. 2007 Sep;56(9):2986-92.


Knee malalignment is associated with an increased risk for incident and enlarging bone marrow lesions in the more loaded compartments: the MOST study.

Hayashi D, Englund M, Roemer FW, Niu J, Sharma L, Felson DT, Crema MD, Marra MD, Segal NA, Lewis CE, Nevitt MC, Guermazi A.

Osteoarthritis Cartilage. 2012 Nov;20(11):1227-33. doi: 10.1016/j.joca.2012.07.020. Epub 2012 Aug 5.


Bone marrow lesions can be subtyped into groups with different clinical outcomes using two magnetic resonance imaging (MRI) sequences.

Wluka AE, Teichtahl AJ, Maulana R, Liu BM, Wang Y, Giles GG, O'Sullivan R, Findlay D, Cicuttini FM.

Arthritis Res Ther. 2015 Sep 27;17:270. doi: 10.1186/s13075-015-0780-5.


Bone marrow lesions predict site-specific cartilage defect development and volume loss: a prospective study in older adults.

Dore D, Martens A, Quinn S, Ding C, Winzenberg T, Zhai G, Pelletier JP, Martel-Pelletier J, Abram F, Cicuttini F, Jones G.

Arthritis Res Ther. 2010;12(6):R222. doi: 10.1186/ar3209. Epub 2010 Dec 29.


Bone marrow lesions from osteoarthritis knees are characterized by sclerotic bone that is less well mineralized.

Hunter DJ, Gerstenfeld L, Bishop G, Davis AD, Mason ZD, Einhorn TA, Maciewicz RA, Newham P, Foster M, Jackson S, Morgan EF.

Arthritis Res Ther. 2009;11(1):R11. doi: 10.1186/ar2601. Epub 2009 Jan 26.


Change in MRI-detected subchondral bone marrow lesions is associated with cartilage loss: the MOST Study. A longitudinal multicentre study of knee osteoarthritis.

Roemer FW, Guermazi A, Javaid MK, Lynch JA, Niu J, Zhang Y, Felson DT, Lewis CE, Torner J, Nevitt MC; MOST Study investigators.

Ann Rheum Dis. 2009 Sep;68(9):1461-5. doi: 10.1136/ard.2008.096834. Epub 2008 Oct 1.


A study of the prevalence and associations of subchondral bone marrow lesions in the knees of healthy, middle-aged women.

Guymer E, Baranyay F, Wluka AE, Hanna F, Bell RJ, Davis SR, Wang Y, Cicuttini FM.

Osteoarthritis Cartilage. 2007 Dec;15(12):1437-42. Epub 2007 Jun 7.


Biochemical markers of bone turnover and their association with bone marrow lesions.

Hunter DJ, Lavalley M, Li J, Bauer DC, Nevitt M, DeGroot J, Poole R, Eyre D, Guermazi A, Gale D, Totterman S, Felson DT.

Arthritis Res Ther. 2008;10(4):R102. doi: 10.1186/ar2494. Epub 2008 Aug 29.


The relationship of tibial bone perfusion to pain in knee osteoarthritis.

Seah S, Wheaton D, Li L, Dyke JP, Talmo C, Harvey WF, Hunter DJ.

Osteoarthritis Cartilage. 2012 Dec;20(12):1527-33. doi: 10.1016/j.joca.2012.08.025. Epub 2012 Sep 7.


Measurement of bone marrow lesions by MR imaging in knee osteoarthritis using quantitative segmentation methods--a reliability and sensitivity to change analysis.

Nielsen FK, Egund N, Peters D, Jurik AG.

BMC Musculoskelet Disord. 2014 Dec 20;15:447. doi: 10.1186/1471-2474-15-447.


Development of bone marrow lesions is associated with adverse effects on knee cartilage while resolution is associated with improvement--a potential target for prevention of knee osteoarthritis: a longitudinal study.

Davies-Tuck ML, Wluka AE, Forbes A, Wang Y, English DR, Giles GG, O'Sullivan R, Cicuttini FM.

Arthritis Res Ther. 2010;12(1):R10. doi: 10.1186/ar2911. Epub 2010 Jan 19.


Association between bone marrow lesions detected by magnetic resonance imaging and knee pain in community residents in Korea.

Kim IJ, Kim DH, Jung JY, Song YW, Guermazi A, Crema MD, Hunter DJ, Kim HA.

Osteoarthritis Cartilage. 2013 Sep;21(9):1207-13. doi: 10.1016/j.joca.2013.05.001.


Bone marrow lesions in knee osteoarthritis change in 6-12 weeks.

Felson DT, Parkes MJ, Marjanovic EJ, Callaghan M, Gait A, Cootes T, Lunt M, Oldham J, Hutchinson CE.

Osteoarthritis Cartilage. 2012 Dec;20(12):1514-8. doi: 10.1016/j.joca.2012.08.020. Epub 2012 Sep 1.


Bone marrow lesions and joint effusion are strongly and independently associated with weight-bearing pain in knee osteoarthritis: data from the osteoarthritis initiative.

Lo GH, McAlindon TE, Niu J, Zhang Y, Beals C, Dabrowski C, Le Graverand MP, Hunter DJ; OAI Investigators Group.

Osteoarthritis Cartilage. 2009 Dec;17(12):1562-9. doi: 10.1016/j.joca.2009.06.006. Epub 2009 Jun 26.


Increase in bone marrow lesions associated with cartilage loss: a longitudinal magnetic resonance imaging study of knee osteoarthritis.

Hunter DJ, Zhang Y, Niu J, Goggins J, Amin S, LaValley MP, Guermazi A, Genant H, Gale D, Felson DT.

Arthritis Rheum. 2006 May;54(5):1529-35.


Correlates of knee bone marrow lesions in younger adults.

Antony B, Venn A, Cicuttini F, March L, Blizzard L, Dwyer T, Halliday A, Cross M, Jones G, Ding C.

Arthritis Res Ther. 2016 Jan 26;18:31. doi: 10.1186/s13075-016-0938-9.

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