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C-type lectin MCL is an FcRγ-coupled receptor that mediates the adjuvanticity of mycobacterial cord factor.

Miyake Y, Toyonaga K, Mori D, Kakuta S, Hoshino Y, Oyamada A, Yamada H, Ono K, Suyama M, Iwakura Y, Yoshikai Y, Yamasaki S.

Immunity. 2013 May 23;38(5):1050-62. doi: 10.1016/j.immuni.2013.03.010. Epub 2013 Apr 18.


Contribution of MINCLE-SYK Signaling to Activation of Primary Human APCs by Mycobacterial Cord Factor and the Novel Adjuvant TDB.

Ostrop J, Jozefowski K, Zimmermann S, Hofmann K, Strasser E, Lepenies B, Lang R.

J Immunol. 2015 Sep 1;195(5):2417-28. doi: 10.4049/jimmunol.1500102. Epub 2015 Jul 22.


C-Type Lectin Receptor MCL Facilitates Mincle Expression and Signaling through Complex Formation.

Miyake Y, Masatsugu OH, Yamasaki S.

J Immunol. 2015 Jun 1;194(11):5366-74. doi: 10.4049/jimmunol.1402429. Epub 2015 Apr 17.


Cutting edge: Mincle is essential for recognition and adjuvanticity of the mycobacterial cord factor and its synthetic analog trehalose-dibehenate.

Schoenen H, Bodendorfer B, Hitchens K, Manzanero S, Werninghaus K, Nimmerjahn F, Agger EM, Stenger S, Andersen P, Ruland J, Brown GD, Wells C, Lang R.

J Immunol. 2010 Mar 15;184(6):2756-60. doi: 10.4049/jimmunol.0904013. Epub 2010 Feb 17.


C-type lectin receptor dectin-3 mediates trehalose 6,6'-dimycolate (TDM)-induced Mincle expression through CARD9/Bcl10/MALT1-dependent nuclear factor (NF)-κB activation.

Zhao XQ, Zhu LL, Chang Q, Jiang C, You Y, Luo T, Jia XM, Lin X.

J Biol Chem. 2014 Oct 24;289(43):30052-62. doi: 10.1074/jbc.M114.588574. Epub 2014 Sep 8.


Neutrophils Promote Mycobacterial Trehalose Dimycolate-Induced Lung Inflammation via the Mincle Pathway.

Lee WB, Kang JS, Yan JJ, Lee MS, Jeon BY, Cho SN, Kim YJ.

PLoS Pathog. 2012;8(4):e1002614. doi: 10.1371/journal.ppat.1002614. Epub 2012 Apr 5.


Characterization of the receptors for mycobacterial cord factor in Guinea pig.

Toyonaga K, Miyake Y, Yamasaki S.

PLoS One. 2014 Feb 12;9(2):e88747. doi: 10.1371/journal.pone.0088747. eCollection 2014.


Mycobacterial receptor, Clec4d (CLECSF8, MCL), is coregulated with Mincle and upregulated on mouse myeloid cells following microbial challenge.

Kerscher B, Wilson GJ, Reid DM, Mori D, Taylor JA, Besra GS, Yamasaki S, Willment JA, Brown GD.

Eur J Immunol. 2016 Feb;46(2):381-9. doi: 10.1002/eji.201545858. Epub 2015 Dec 8.


Differential control of Mincle-dependent cord factor recognition and macrophage responses by the transcription factors C/EBPβ and HIF1α.

Schoenen H, Huber A, Sonda N, Zimmermann S, Jantsch J, Lepenies B, Bronte V, Lang R.

J Immunol. 2014 Oct 1;193(7):3664-75. doi: 10.4049/jimmunol.1301593. Epub 2014 Aug 25.


Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle.

Ishikawa E, Ishikawa T, Morita YS, Toyonaga K, Yamada H, Takeuchi O, Kinoshita T, Akira S, Yoshikai Y, Yamasaki S.

J Exp Med. 2009 Dec 21;206(13):2879-88. doi: 10.1084/jem.20091750. Epub 2009 Dec 14.


Mincle is not essential for controlling Mycobacterium tuberculosis infection.

Heitmann L, Schoenen H, Ehlers S, Lang R, Hölscher C.

Immunobiology. 2013 Apr;218(4):506-16. doi: 10.1016/j.imbio.2012.06.005. Epub 2012 Jun 21.


Structural analysis for glycolipid recognition by the C-type lectins Mincle and MCL.

Furukawa A, Kamishikiryo J, Mori D, Toyonaga K, Okabe Y, Toji A, Kanda R, Miyake Y, Ose T, Yamasaki S, Maenaka K.

Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17438-43. doi: 10.1073/pnas.1312649110. Epub 2013 Oct 7.


The Mincle-activating adjuvant TDB induces MyD88-dependent Th1 and Th17 responses through IL-1R signaling.

Desel C, Werninghaus K, Ritter M, Jozefowski K, Wenzel J, Russkamp N, Schleicher U, Christensen D, Wirtz S, Kirschning C, Agger EM, Prazeres da Costa C, Lang R.

PLoS One. 2013;8(1):e53531. doi: 10.1371/journal.pone.0053531. Epub 2013 Jan 7.


Trehalose diester glycolipids are superior to the monoesters in binding to Mincle, activation of macrophages in vitro and adjuvant activity in vivo.

Huber A, Kallerup RS, Korsholm KS, Franzyk H, Lepenies B, Christensen D, Foged C, Lang R.

Innate Immun. 2016 Aug;22(6):405-18. doi: 10.1177/1753425916651132. Epub 2016 Jun 1.


Mincle is a long sought receptor for mycobacterial cord factor.

Matsunaga I, Moody DB.

J Exp Med. 2009 Dec 21;206(13):2865-8. doi: 10.1084/jem.20092533. Epub 2009 Dec 14.


Macrophage-inducible C-type lectin Mincle-expressing dendritic cells contribute to control of splenic Mycobacterium bovis BCG infection in mice.

Behler F, Maus R, Bohling J, Knippenberg S, Kirchhof G, Nagata M, Jonigk D, Izykowski N, Mägel L, Welte T, Yamasaki S, Maus UA.

Infect Immun. 2015 Jan;83(1):184-96. doi: 10.1128/IAI.02500-14. Epub 2014 Oct 20.


Signalling through MyD88 drives surface expression of the mycobacterial receptors MCL (Clecsf8, Clec4d) and Mincle (Clec4e) following microbial stimulation.

Kerscher B, Dambuza IM, Christofi M, Reid DM, Yamasaki S, Willment JA, Brown GD.

Microbes Infect. 2016 Jul-Aug;18(7-8):505-9. doi: 10.1016/j.micinf.2016.03.007. Epub 2016 Mar 19.


MARCO, TLR2, and CD14 are required for macrophage cytokine responses to mycobacterial trehalose dimycolate and Mycobacterium tuberculosis.

Bowdish DM, Sakamoto K, Kim MJ, Kroos M, Mukhopadhyay S, Leifer CA, Tryggvason K, Gordon S, Russell DG.

PLoS Pathog. 2009 Jun;5(6):e1000474. doi: 10.1371/journal.ppat.1000474. Epub 2009 Jun 12.


Mincle-mediated anti-inflammatory IL-10 response counter-regulates IL-12 in vitro.

Patin EC, Willcocks S, Orr S, Ward TH, Lang R, Schaible UE.

Innate Immun. 2016 Apr;22(3):181-5. doi: 10.1177/1753425916636671. Epub 2016 Mar 2.


Recognition of the mycobacterial cord factor by Mincle: relevance for granuloma formation and resistance to tuberculosis.

Lang R.

Front Immunol. 2013 Jan 24;4:5. doi: 10.3389/fimmu.2013.00005. eCollection 2013.

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