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Items: 1 to 20 of 71

1.

Heme degradation by Staphylococcus aureus IsdG and IsdI liberates formaldehyde rather than carbon monoxide.

Matsui T, Nambu S, Ono Y, Goulding CW, Tsumoto K, Ikeda-Saito M.

Biochemistry. 2013 May 7;52(18):3025-7. doi: 10.1021/bi400382p. Epub 2013 Apr 24.

2.

Ruffling of metalloporphyrins bound to IsdG and IsdI, two heme-degrading enzymes in Staphylococcus aureus.

Lee WC, Reniere ML, Skaar EP, Murphy ME.

J Biol Chem. 2008 Nov 7;283(45):30957-63. doi: 10.1074/jbc.M709486200. Epub 2008 Aug 19.

3.

The IsdG-family of haem oxygenases degrades haem to a novel chromophore.

Reniere ML, Ukpabi GN, Harry SR, Stec DF, Krull R, Wright DW, Bachmann BO, Murphy ME, Skaar EP.

Mol Microbiol. 2010 Mar;75(6):1529-38. doi: 10.1111/j.1365-2958.2010.07076.x. Epub 2010 Feb 17.

4.

A new way to degrade heme: the Mycobacterium tuberculosis enzyme MhuD catalyzes heme degradation without generating CO.

Nambu S, Matsui T, Goulding CW, Takahashi S, Ikeda-Saito M.

J Biol Chem. 2013 Apr 5;288(14):10101-9. doi: 10.1074/jbc.M112.448399. Epub 2013 Feb 18.

5.

IruO is a reductase for heme degradation by IsdI and IsdG proteins in Staphylococcus aureus.

Loutet SA, Kobylarz MJ, Chau CH, Murphy ME.

J Biol Chem. 2013 Sep 6;288(36):25749-59. doi: 10.1074/jbc.M113.470518. Epub 2013 Jul 26.

6.

Inactivation of the heme degrading enzyme IsdI by an active site substitution that diminishes heme ruffling.

Ukpabi G, Takayama SJ, Mauk AG, Murphy ME.

J Biol Chem. 2012 Oct 5;287(41):34179-88. doi: 10.1074/jbc.M112.393249. Epub 2012 Aug 13.

7.

Staphylococcus aureus haem oxygenases are differentially regulated by iron and haem.

Reniere ML, Skaar EP.

Mol Microbiol. 2008 Sep;69(5):1304-15. doi: 10.1111/j.1365-2958.2008.06363.x. Epub 2008 Jul 10.

8.

The flexible loop of Staphylococcus aureus IsdG is required for its degradation in the absence of heme.

Reniere ML, Haley KP, Skaar EP.

Biochemistry. 2011 Aug 9;50(31):6730-7. doi: 10.1021/bi200999q. Epub 2011 Jul 11.

9.

Time-resolved Studies of IsdG Protein Identify Molecular Signposts along the Non-canonical Heme Oxygenase Pathway.

Streit BR, Kant R, Tokmina-Lukaszewska M, Celis AI, Machovina MM, Skaar EP, Bothner B, DuBois JL.

J Biol Chem. 2016 Jan 8;291(2):862-71. doi: 10.1074/jbc.M115.666560. Epub 2015 Nov 3.

10.

IsdG and IsdI, heme-degrading enzymes in the cytoplasm of Staphylococcus aureus.

Skaar EP, Gaspar AH, Schneewind O.

J Biol Chem. 2004 Jan 2;279(1):436-43. Epub 2003 Oct 21.

11.

Staphylococcus aureus IsdG and IsdI, heme-degrading enzymes with structural similarity to monooxygenases.

Wu R, Skaar EP, Zhang R, Joachimiak G, Gornicki P, Schneewind O, Joachimiak A.

J Biol Chem. 2005 Jan 28;280(4):2840-6. Epub 2004 Oct 31.

12.

Unusual diheme conformation of the heme-degrading protein from Mycobacterium tuberculosis.

Chim N, Iniguez A, Nguyen TQ, Goulding CW.

J Mol Biol. 2010 Jan 22;395(3):595-608. doi: 10.1016/j.jmb.2009.11.025. Epub 2009 Nov 14.

13.

Electronic properties of the highly ruffled heme bound to the heme degrading enzyme IsdI.

Takayama SJ, Ukpabi G, Murphy ME, Mauk AG.

Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13071-6. doi: 10.1073/pnas.1101459108. Epub 2011 Jul 25.

14.

Crystallographic and spectroscopic insights into heme degradation by Mycobacterium tuberculosis MhuD.

Graves AB, Morse RP, Chao A, Iniguez A, Goulding CW, Liptak MD.

Inorg Chem. 2014 Jun 16;53(12):5931-40. doi: 10.1021/ic500033b. Epub 2014 Jun 5.

15.

Heme utilization by pathogenic bacteria: not all pathways lead to biliverdin.

Wilks A, Ikeda-Saito M.

Acc Chem Res. 2014 Aug 19;47(8):2291-8. doi: 10.1021/ar500028n. Epub 2014 May 29.

16.
17.

A Ferric-Peroxo Intermediate in the Oxidation of Heme by IsdI.

Takayama SJ, Loutet SA, Mauk AG, Murphy ME.

Biochemistry. 2015 Apr 28;54(16):2613-21. doi: 10.1021/acs.biochem.5b00239. Epub 2015 Apr 16.

PMID:
25853501
18.

Heme oxygenation and the widening paradigm of heme degradation.

Wilks A, Heinzl G.

Arch Biochem Biophys. 2014 Feb 15;544:87-95. doi: 10.1016/j.abb.2013.10.013. Epub 2013 Oct 23. Review.

PMID:
24161941
19.

Unique coupling of mono- and dioxygenase chemistries in a single active site promotes heme degradation.

Matsui T, Nambu S, Goulding CW, Takahashi S, Fujii H, Ikeda-Saito M.

Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):3779-84. doi: 10.1073/pnas.1523333113. Epub 2016 Mar 22.

20.

Dynamic ruffling distortion of the heme substrate in non-canonical heme oxygenase enzymes.

Graves AB, Horak EH, Liptak MD.

Dalton Trans. 2016 Jun 14;45(24):10058-67. doi: 10.1039/c6dt00702c.

PMID:
27273757

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