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1-Benzyl-indole-3-carbinol is a novel indole-3-carbinol derivative with significantly enhanced potency of anti-proliferative and anti-estrogenic properties in human breast cancer cells.

Nguyen HH, Lavrenov SN, Sundar SN, Nguyen DH, Tseng M, Marconett CN, Kung J, Staub RE, Preobrazhenskaya MN, Bjeldanes LF, Firestone GL.

Chem Biol Interact. 2010 Aug 5;186(3):255-66. doi: 10.1016/j.cbi.2010.05.015.


Hedgehog signaling and response to cyclopamine differ in epithelial and stromal cells in benign breast and breast cancer.

Mukherjee S, Frolova N, Sadlonova A, Novak Z, Steg A, Page GP, Welch DR, Lobo-Ruppert SM, Ruppert JM, Johnson MR, Frost AR.

Cancer Biol Ther. 2006 Jun;5(6):674-83.


Effects of inhibition of hedgehog signaling on cell growth and migration of uveal melanoma cells.

Duan F, Lin M, Li C, Ding X, Qian G, Zhang H, Ge S, Fan X, Li J.

Cancer Biol Ther. 2014 May;15(5):544-59. doi: 10.4161/cbt.28157.


Cyclopamine inhibition of human breast cancer cell growth independent of Smoothened (Smo).

Zhang X, Harrington N, Moraes RC, Wu MF, Hilsenbeck SG, Lewis MT.

Breast Cancer Res Treat. 2009 Jun;115(3):505-21. doi: 10.1007/s10549-008-0093-3.


LKB1 inhibits breast cancer partially through repressing the Hedgehog signaling pathway.

Zhuang Z, Wang K, Cheng X, Qu X, Jiang B, Li Z, Luo J, Shao Z, Duan T.

PLoS One. 2013 Jul 4;8(7):e67431. doi: 10.1371/journal.pone.0067431.


Benzopyran derivative CDRI-85/287 induces G2-M arrest in estrogen receptor-positive breast cancer cells via modulation of estrogen receptors α- and β-mediated signaling, in parallel to EGFR signaling and suppresses the growth of tumor xenograft.

Saxena R, Fatima I, Chandra V, Blesson CS, Kharkwal G, Hussain MK, Hajela K, Roy BG, Dwivedi A.

Steroids. 2013 Nov;78(11):1071-86. doi: 10.1016/j.steroids.2013.07.004.


Decursin and decursinol angelate inhibit estrogen-stimulated and estrogen-independent growth and survival of breast cancer cells.

Jiang C, Guo J, Wang Z, Xiao B, Lee HJ, Lee EO, Kim SH, Lu J.

Breast Cancer Res. 2007;9(6):R77.


Anterior gradient-2 plays a critical role in breast cancer cell growth and survival by modulating cyclin D1, estrogen receptor-alpha and survivin.

Vanderlaag KE, Hudak S, Bald L, Fayadat-Dilman L, Sathe M, Grein J, Janatpour MJ.

Breast Cancer Res. 2010;12(3):R32. doi: 10.1186/bcr2586.


Drug resistance is dramatically restored by hedgehog inhibitors in CD34+ leukemic cells.

Kobune M, Takimoto R, Murase K, Iyama S, Sato T, Kikuchi S, Kawano Y, Miyanishi K, Sato Y, Niitsu Y, Kato J.

Cancer Sci. 2009 May;100(5):948-55. doi: 10.1111/j.1349-7006.2009.01111.x.


The Hedgehog pathway is a possible therapeutic target for patients with estrogen receptor-negative breast cancer.

Kameda C, Tanaka H, Yamasaki A, Nakamura M, Koga K, Sato N, Kubo M, Kuroki S, Tanaka M, Katano M.

Anticancer Res. 2009 Mar;29(3):871-9.


Cyclopamine treatment of full-blown Hh/Ptch-associated RMS partially inhibits Hh/Ptch signaling, but not tumor growth.

Ecke I, Rosenberger A, Obenauer S, Dullin C, Aberger F, Kimmina S, Schweyer S, Hahn H.

Mol Carcinog. 2008 May;47(5):361-72.


Impact of the Smoothened inhibitor, IPI-926, on smoothened ciliary localization and Hedgehog pathway activity.

Peluso MO, Campbell VT, Harari JA, Tibbitts TT, Proctor JL, Whitebread N, Conley JM, White KF, Kutok JL, Read MA, McGovern K, Faia KL.

PLoS One. 2014 Mar 7;9(3):e90534. doi: 10.1371/journal.pone.0090534.


The Hedgehog Inhibitor Cyclopamine Reduces β-Catenin-Tcf Transcriptional Activity, Induces E-Cadherin Expression, and Reduces Invasion in Colorectal Cancer Cells.

Qualtrough D, Rees P, Speight B, Williams AC, Paraskeva C.

Cancers (Basel). 2015 Sep 17;7(3):1885-99. doi: 10.3390/cancers7030867.

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