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Huaier aqueous extract inhibits colorectal cancer stem cell growth partially via downregulation of the Wnt/β-catenin pathway.

Zhang T, Wang K, Zhang J, Wang X, Chen Z, Ni C, Qiu F, Huang J.

Oncol Lett. 2013 Apr;5(4):1171-1176. Epub 2013 Jan 21.


Huaier aqueous extract inhibits stem-like characteristics of MCF7 breast cancer cells via inactivation of hedgehog pathway.

Wang X, Zhang N, Huo Q, Sun M, Dong L, Zhang Y, Xu G, Yang Q.

Tumour Biol. 2014 Nov;35(11):10805-13. doi: 10.1007/s13277-014-2390-2. Epub 2014 Jul 31.


Huaier aqueous extract inhibits ovarian cancer cell motility via the AKT/GSK3β/β-catenin pathway.

Yan X, Lyu T, Jia N, Yu Y, Hua K, Feng W.

PLoS One. 2013 May 8;8(5):e63731. doi: 10.1371/journal.pone.0063731. Print 2013.


Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells.

Li Y, Zhang T, Korkaya H, Liu S, Lee HF, Newman B, Yu Y, Clouthier SG, Schwartz SJ, Wicha MS, Sun D.

Clin Cancer Res. 2010 May 1;16(9):2580-90. doi: 10.1158/1078-0432.CCR-09-2937. Epub 2010 Apr 13.


(-)-Epigallocatechin-3-Gallate Inhibits Colorectal Cancer Stem Cells by Suppressing Wnt/β-Catenin Pathway.

Chen Y, Wang XQ, Zhang Q, Zhu JY, Li Y, Xie CF, Li XT, Wu JS, Geng SS, Zhong CY, Han HY.

Nutrients. 2017 Jun 3;9(6). pii: E572. doi: 10.3390/nu9060572.


Huaier aqueous extract induces apoptosis of human fibrosarcoma HT1080 cells through the mitochondrial pathway.

Cui Y, Meng H, Liu W, Wang H, Liu Q.

Oncol Lett. 2015 Apr;9(4):1590-1596. Epub 2015 Jan 27.


CWP232228 targets liver cancer stem cells through Wnt/β-catenin signaling: a novel therapeutic approach for liver cancer treatment.

Kim JY, Lee HY, Park KK, Choi YK, Nam JS, Hong IS.

Oncotarget. 2016 Apr 12;7(15):20395-409. doi: 10.18632/oncotarget.7954.


Anti-angiogenic and antitumor activities of Huaier aqueous extract.

Wang X, Zhang N, Huo Q, Yang Q.

Oncol Rep. 2012 Oct;28(4):1167-75. doi: 10.3892/or.2012.1961. Epub 2012 Aug 8.


Huaier Aqueous Extract Induces Hepatocellular Carcinoma Cells Arrest in S Phase via JNK Signaling Pathway.

Zhang C, Zhang J, Li X, Sun N, Yu R, Zhao B, Yu D, Cheng Y, Liu Y.

Evid Based Complement Alternat Med. 2015;2015:171356. doi: 10.1155/2015/171356. Epub 2015 Jun 28.


Huaier aqueous extract inhibits proliferation of breast cancer cells by inducing apoptosis.

Zhang N, Kong X, Yan S, Yuan C, Yang Q.

Cancer Sci. 2010 Nov;101(11):2375-83. doi: 10.1111/j.1349-7006.2010.01680.x.


Effects of Huaier aqueous extract on proliferation and apoptosis in the melanoma cell line A875.

Zhang F, Zhang Z, Liu Z.

Acta Histochem. 2013 Sep;115(7):705-11. doi: 10.1016/j.acthis.2013.02.010. Epub 2013 Apr 16.


Huaier aqueous extract inhibits cervical cancer cell proliferation via JNK/p38 pathway.

Yan L, Liu X, Yin A, Wei Y, Yang Q, Kong B.

Int J Oncol. 2015 Sep;47(3):1054-60. doi: 10.3892/ijo.2015.3094. Epub 2015 Jul 20.


The Wnt/β-catenin pathway regulates self-renewal of cancer stem-like cells in human gastric cancer.

Cai C, Zhu X.

Mol Med Rep. 2012 May;5(5):1191-6. doi: 10.3892/mmr.2012.802. Epub 2012 Feb 21.


Transition from colitis to cancer: high Wnt activity sustains the tumor-initiating potential of colon cancer stem cell precursors.

Shenoy AK, Fisher RC, Butterworth EA, Pi L, Chang LJ, Appelman HD, Chang M, Scott EW, Huang EH.

Cancer Res. 2012 Oct 1;72(19):5091-100. doi: 10.1158/0008-5472.CAN-12-1806. Epub 2012 Aug 17.


Upregulation of miR-199a/b contributes to cisplatin resistance via Wnt/β-catenin-ABCG2 signaling pathway in ALDHA1+ colorectal cancer stem cells.

Chen B, Zhang D, Kuai J, Cheng M, Fang X, Li G.

Tumour Biol. 2017 Jun;39(6):1010428317715155. doi: 10.1177/1010428317715155.


Huaier extract synergizes with tamoxifen to induce autophagy and apoptosis in ER-positive breast cancer cells.

Qi W, Sun M, Kong X, Li Y, Wang X, Lv S, Ding X, Gao S, Cun J, Cai C, Wang X, Chen J, Yin A, Yang Q.

Oncotarget. 2016 May 3;7(18):26003-15. doi: 10.18632/oncotarget.8303.


Overexpression of PER3 Inhibits Self-Renewal Capability and Chemoresistance of Colorectal Cancer Stem-Like Cells via Inhibition of Notch and β-Catenin Signaling.

Zhang F, Sun H, Zhang S, Yang X, Zhang G, Su T.

Oncol Res. 2017 May 24;25(5):709-719. doi: 10.3727/096504016X14772331883976. Epub 2016 Oct 26.


Identification of multi-target effects of Huaier aqueous extract via microarray profiling in triple-negative breast cancer cells.

Kong X, Ding X, Yang Q.

Int J Oncol. 2015 May;46(5):2047-56. doi: 10.3892/ijo.2015.2932. Epub 2015 Mar 17.


Huaier Extract Induces Autophagic Cell Death by Inhibiting the mTOR/S6K Pathway in Breast Cancer Cells.

Wang X, Qi W, Li Y, Zhang N, Dong L, Sun M, Cun J, Zhang Y, Lv S, Yang Q.

PLoS One. 2015 Jul 2;10(7):e0131771. doi: 10.1371/journal.pone.0131771. eCollection 2015.


8-bromo-7-methoxychrysin inhibits properties of liver cancer stem cells via downregulation of β-catenin.

Quan MF, Xiao LH, Liu ZH, Guo H, Ren KQ, Liu F, Cao JG, Deng XY.

World J Gastroenterol. 2013;19(43):7680-95. doi: 10.3748/wjg.v19.i43.7680.

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