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Items: 1 to 20 of 103

1.

Discovery, synthesis and in combo studies of a tetrazole analogue of clofibric acid as a potent hypoglycemic agent.

Navarrete-Vázquez G, Alaniz-Palacios A, Hidalgo-Figueroa S, González-Acevedo C, Ávila-Villarreal G, Estrada-Soto S, Webster SP, Medina-Franco JL, López-Vallejo F, Guerrero-Álvarez J, Tlahuext H.

Bioorg Med Chem Lett. 2013 Jun 1;23(11):3244-7. doi: 10.1016/j.bmcl.2013.03.122.

PMID:
23597793
2.

Synthesis of 2-{2-[(α/β-naphthalen-1-ylsulfonyl)amino]-1,3-thiazol-4-yl} acetamides with 11β-hydroxysteroid dehydrogenase inhibition and in combo antidiabetic activities.

Navarrete-Vázquez G, Morales-Vilchis MG, Estrada-Soto S, Ramírez-Espinosa JJ, Hidalgo-Figueroa S, Nava-Zuazo C, Tlahuext H, Leon-Rivera I, Medina-Franco JL, López-Vallejo F, Webster SP, Binnie M, Ortiz-Andrade R, Moreno-Diaz H.

Eur J Med Chem. 2014 Mar 3;74:179-86. doi: 10.1016/j.ejmech.2013.12.042.

PMID:
24462849
3.

Discovery of thiazolidine-2,4-dione/biphenylcarbonitrile hybrid as dual PPAR α/γ modulator with antidiabetic effect: in vitro, in silico and in vivo approaches.

Hidalgo-Figueroa S, Ramírez-Espinosa JJ, Estrada-Soto S, Almanza-Pérez JC, Román-Ramos R, Alarcón-Aguilar FJ, Hernández-Rosado JV, Moreno-Díaz H, Díaz-Coutiño D, Navarrete-Vázquez G.

Chem Biol Drug Des. 2013 Apr;81(4):474-83. doi: 10.1111/cbdd.12102.

PMID:
23289972
4.

Synthesis and structure-activity relationship of 2-adamantylmethyl tetrazoles as potent and selective inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1).

Ye XY, Yoon D, Chen SY, Nayeem A, Golla R, Seethala R, Wang M, Harper T, Sleczka BG, Apedo A, Li YX, He B, Kirby M, Gordon DA, Robl JA.

Bioorg Med Chem Lett. 2014 Jan 15;24(2):654-60. doi: 10.1016/j.bmcl.2013.11.066.

PMID:
24360604
5.

Antidiabetic activity of N-(6-substituted-1,3-benzothiazol-2-yl)benzenesulfonamides.

Moreno-Díaz H, Villalobos-Molina R, Ortiz-Andrade R, Díaz-Coutiño D, Medina-Franco JL, Webster SP, Binnie M, Estrada-Soto S, Ibarra-Barajas M, León-Rivera I, Navarrete-Vázquez G.

Bioorg Med Chem Lett. 2008 May 1;18(9):2871-7. doi: 10.1016/j.bmcl.2008.03.086.

PMID:
18424136
6.

2-amino-1,3-thiazol-4(5H)-ones as potent and selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: enzyme-ligand co-crystal structure and demonstration of pharmacodynamic effects in C57Bl/6 mice.

Johansson L, Fotsch C, Bartberger MD, Castro VM, Chen M, Emery M, Gustafsson S, Hale C, Hickman D, Homan E, Jordan SR, Komorowski R, Li A, McRae K, Moniz G, Matsumoto G, Orihuela C, Palm G, Veniant M, Wang M, Williams M, Zhang J.

J Med Chem. 2008 May 22;51(10):2933-43. doi: 10.1021/jm701551j.

PMID:
18419108
7.

A comparative study of flavonoid analogues on streptozotocin-nicotinamide induced diabetic rats: quercetin as a potential antidiabetic agent acting via 11beta-hydroxysteroid dehydrogenase type 1 inhibition.

Torres-Piedra M, Ortiz-Andrade R, Villalobos-Molina R, Singh N, Medina-Franco JL, Webster SP, Binnie M, Navarrete-Vázquez G, Estrada-Soto S.

Eur J Med Chem. 2010 Jun;45(6):2606-12. doi: 10.1016/j.ejmech.2010.02.049.

PMID:
20346546
8.

Antihyperglycemic and sub-chronic antidiabetic actions of morolic and moronic acids, in vitro and in silico inhibition of 11β-HSD 1.

Ramírez-Espinosa JJ, García-Jiménez S, Rios MY, Medina-Franco JL, López-Vallejo F, Webster SP, Binnie M, Ibarra-Barajas M, Ortiz-Andrade R, Estrada-Soto S.

Phytomedicine. 2013 May 15;20(7):571-6. doi: 10.1016/j.phymed.2013.01.013.

PMID:
23453304
9.

Discovery of novel sulfonamides as potent and selective inhibitors against human and mouse 11β-hydroxysteroid dehydrogenase type 1.

Xia G, Liu L, Xue M, Liu H, Yu J, Li P, Chen Q, Xiong B, Liu X, Shen J.

Mol Cell Endocrinol. 2012 Jul 6;358(1):46-52. doi: 10.1016/j.mce.2012.02.017.

PMID:
22410288
10.

Arylsulfonamidothiazoles as a new class of potential antidiabetic drugs. Discovery of potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1.

Barf T, Vallgårda J, Emond R, Häggström C, Kurz G, Nygren A, Larwood V, Mosialou E, Axelsson K, Olsson R, Engblom L, Edling N, Rönquist-Nii Y, Ohman B, Alberts P, Abrahmsén L.

J Med Chem. 2002 Aug 29;45(18):3813-5.

PMID:
12190302
11.

Discovery of novel inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 by docking and pharmacophore modeling.

Yang H, Dou W, Lou J, Leng Y, Shen J.

Bioorg Med Chem Lett. 2008 Feb 15;18(4):1340-5. doi: 10.1016/j.bmcl.2008.01.020.

PMID:
18242087
12.

Discovery of novel dual functional agent as PPARgamma agonist and 11beta-HSD1 inhibitor for the treatment of diabetes.

Ye YL, Zhou Z, Zou HJ, Shen Y, Xu TF, Tang J, Yin HZ, Chen ML, Leng Y, Shen JH.

Bioorg Med Chem. 2009 Aug 1;17(15):5722-32. doi: 10.1016/j.bmc.2009.05.082.

PMID:
19574056
13.

Synthesis, in vitro and in silico studies of a PPARγ and GLUT-4 modulator with hypoglycemic effect.

Navarrete-Vázquez G, Torres-Gómez H, Hidalgo-Figueroa S, Ramírez-Espinosa JJ, Estrada-Soto S, Medina-Franco JL, León-Rivera I, Alarcón-Aguilar FJ, Almanza-Pérez JC.

Bioorg Med Chem Lett. 2014 Sep 15;24(18):4575-9. doi: 10.1016/j.bmcl.2014.07.068.

PMID:
25131539
14.

Azabicyclic sulfonamides as potent 11beta-HSD1 inhibitors.

Shah U, Boyle CD, Chackalamannil S, Baker H, Kowalski T, Lee J, Terracina G, Zhang L.

Bioorg Med Chem Lett. 2010 Mar 1;20(5):1551-4. doi: 10.1016/j.bmcl.2010.01.082.

PMID:
20149650
15.

Synthesis and biological evaluation of picolinamides as potent inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1).

Ryu JH, Kim S, Han HY, Son HJ, Lee HJ, Shin YA, Kim JS, Park HG.

Bioorg Med Chem Lett. 2015 Feb 1;25(3):695-700. doi: 10.1016/j.bmcl.2014.11.074.

PMID:
25529735
16.

Crystal structure of murine 11 beta-hydroxysteroid dehydrogenase 1: an important therapeutic target for diabetes.

Zhang J, Osslund TD, Plant MH, Clogston CL, Nybo RE, Xiong F, Delaney JM, Jordan SR.

Biochemistry. 2005 May 10;44(18):6948-57.

PMID:
15865440
17.
18.

Synthesis of novel curcumin analogues for inhibition of 11β-hydroxysteroid dehydrogenase type 1 with anti-diabetic properties.

Yuan X, Li H, Bai H, Su Z, Xiang Q, Wang C, Zhao B, Zhang Y, Zhang Q, Chu Y, Huang Y.

Eur J Med Chem. 2014 Apr 22;77:223-30. doi: 10.1016/j.ejmech.2014.03.012.

PMID:
24642565
19.

Antidiabetic and toxicological evaluations of naringenin in normoglycaemic and NIDDM rat models and its implications on extra-pancreatic glucose regulation.

Ortiz-Andrade RR, Sánchez-Salgado JC, Navarrete-Vázquez G, Webster SP, Binnie M, García-Jiménez S, León-Rivera I, Cigarroa-Vázquez P, Villalobos-Molina R, Estrada-Soto S.

Diabetes Obes Metab. 2008 Nov;10(11):1097-104. doi: 10.1111/j.1463-1326.2008.00869.x.

PMID:
18355329
20.

Discovery of adamantyl heterocyclic ketones as potent 11β-hydroxysteroid dehydrogenase type 1 inhibitors.

Su X, Vicker N, Thomas MP, Pradaux-Caggiano F, Halem H, Culler MD, Potter BV.

ChemMedChem. 2011 Aug 1;6(8):1439-51. doi: 10.1002/cmdc.201100144.

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