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Pivotal role of mouse mast cell protease 4 in the conversion and pressor properties of Big-endothelin-1.

Houde M, Jamain MD, Labonté J, Desbiens L, Pejler G, Gurish M, Takai S, D'Orléans-Juste P.

J Pharmacol Exp Ther. 2013 Jul;346(1):31-7. doi: 10.1124/jpet.112.202275. Epub 2013 Apr 17.


Chymase inhibitor-sensitive synthesis of endothelin-1 (1-31) by recombinant mouse mast cell protease 4 and human chymase.

Semaan W, Desbiens L, Houde M, Labonté J, Gagnon H, Yamamoto D, Takai S, Laidlaw T, Bkaily G, Schwertani A, Pejler G, Levesque C, Desjardins R, Day R, D'Orléans-Juste P.

Biochem Pharmacol. 2015 Mar 15;94(2):91-100. doi: 10.1016/j.bcp.2015.02.001. Epub 2015 Feb 7.


Chymase-dependent conversion of Big endothelin-1 in the mouse in vivo.

Simard E, Jin D, Takai S, Miyazaki M, Brochu I, D'Orléans-Juste P.

J Pharmacol Exp Ther. 2009 Feb;328(2):540-8. doi: 10.1124/jpet.108.142992. Epub 2008 Nov 5.


Endothelin-1 (1-31) is an intermediate in the production of endothelin-1 after big endothelin-1 administration in vivo.

Fecteau MH, Honoré JC, Plante M, Labonté J, Rae GA, D'Orléans-Juste P.

Hypertension. 2005 Jul;46(1):87-92. Epub 2005 Jun 13.


Significant Contribution of Mouse Mast Cell Protease 4 in Early Phases of Experimental Autoimmune Encephalomyelitis.

Desbiens L, Lapointe C, Gharagozloo M, Mahmoud S, Pejler G, Gris D, D'Orléans-Juste P.

Mediators Inflamm. 2016;2016:9797021. doi: 10.1155/2016/9797021. Epub 2016 Aug 17.


Enzymatic pathways involved in the generation of endothelin-1(1-31) from exogenous big endothelin-1 in the rabbit aorta.

Tirapelli CR, Fecteau MH, Honore JC, Legros E, Gobeil F, D'Orleans-Juste P.

Br J Pharmacol. 2006 Jun;148(4):527-35. Epub 2006 Apr 24.


Cooperation between mast cell carboxypeptidase A and the chymase mouse mast cell protease 4 in the formation and degradation of angiotensin II.

Lundequist A, Tchougounova E, Abrink M, Pejler G.

J Biol Chem. 2004 Jul 30;279(31):32339-44. Epub 2004 Jun 1.


The specific chymase inhibitor TY-51469 suppresses the accumulation of neutrophils in the lung and reduces silica-induced pulmonary fibrosis in mice.

Takato H, Yasui M, Ichikawa Y, Waseda Y, Inuzuka K, Nishizawa Y, Tagami A, Fujimura M, Nakao S.

Exp Lung Res. 2011 Mar;37(2):101-8. doi: 10.3109/01902148.2010.520815. Epub 2010 Dec 4.


Experimental Autoimmune Encephalomyelitis Potentiates Mouse Mast Cell Protease 4-Dependent Pressor Responses to Centrally or Systemically Administered Big Endothelin-1.

Desbiens L, Lapointe C, Gendron L, Gharagozloo M, Vincent L, Pejler G, Gris D, D'Orléans-Juste P.

J Pharmacol Exp Ther. 2019 Sep;370(3):437-446. doi: 10.1124/jpet.118.256016. Epub 2019 Jun 27.


Mouse mast cell protease-1 cleaves angiotensin I to form angiotensin II.

Saito K, Muto T, Tomimori Y, Imajo S, Maruoka H, Tanaka T, Yamashiro K, Fukuda Y.

Biochem Biophys Res Commun. 2003 Mar 21;302(4):773-7.


Mouse mast cell protease 4 is the major chymase in murine airways and has a protective role in allergic airway inflammation.

Waern I, Jonasson S, Hjoberg J, Bucht A, Abrink M, Pejler G, Wernersson S.

J Immunol. 2009 Nov 15;183(10):6369-76. doi: 10.4049/jimmunol.0900180. Epub 2009 Oct 19.


The chymase mouse mast cell protease 4 degrades TNF, limits inflammation, and promotes survival in a model of sepsis.

Piliponsky AM, Chen CC, Rios EJ, Treuting PM, Lahiri A, Abrink M, Pejler G, Tsai M, Galli SJ.

Am J Pathol. 2012 Sep;181(3):875-86. doi: 10.1016/j.ajpath.2012.05.013.


Mouse Mast Cell Protease 4 Deletion Protects Heart Function and Survival After Permanent Myocardial Infarction.

Houde M, Schwertani A, Touil H, Desbiens L, Sarrhini O, Lecomte R, Lepage M, Gagnon H, Takai S, Pejler G, Jacques D, Gobeil F Jr, Day R, D'Orléans-Juste P.

Front Pharmacol. 2018 Aug 31;9:868. doi: 10.3389/fphar.2018.00868. eCollection 2018.


Critical role of mast cell chymase in mouse abdominal aortic aneurysm formation.

Sun J, Zhang J, Lindholt JS, Sukhova GK, Liu J, He A, Abrink M, Pejler G, Stevens RL, Thompson RW, Ennis TL, Gurish MF, Libby P, Shi GP.

Circulation. 2009 Sep 15;120(11):973-82. doi: 10.1161/CIRCULATIONAHA.109.849679. Epub 2009 Aug 31.


Endothelin receptor antagonist macitentan or deletion of mouse mast cell protease 4 delays lesion development in atherosclerotic mice.

Houde M, Desbiens L, Schwertani A, Pejler G, Iglarz M, D'Orléans-Juste P.

Life Sci. 2016 Aug 15;159:71-75. doi: 10.1016/j.lfs.2016.03.018. Epub 2016 Mar 12.


Endothelin-1 (1-31): from chymase-dependent synthesis to cardiovascular pathologies.

D'Orléans-Juste P, Houde M, Rae GA, Bkaily G, Carrier E, Simard E.

Vascul Pharmacol. 2008 Aug-Sep;49(2-3):51-62. doi: 10.1016/j.vph.2008.06.007. Epub 2008 Jul 12. Review.


Involvement of chymase-mediated angiotensin II generation in blood pressure regulation.

Li M, Liu K, Michalicek J, Angus JA, Hunt JE, Dell'Italia LJ, Feneley MP, Graham RM, Husain A.

J Clin Invest. 2004 Jul;114(1):112-20.


Deficient transcription of mouse mast cell protease 4 gene in mutant mice of mi/mi genotype.

Jippo T, Lee YM, Katsu Y, Tsujino K, Morii E, Kim DK, Kim HM, Kitamura Y.

Blood. 1999 Mar 15;93(6):1942-50.


A closely linked complex of mouse mast cell-specific chymase genes on chromosome 14.

Gurish MF, Nadeau JH, Johnson KR, McNeil HP, Grattan KM, Austen KF, Stevens RL.

J Biol Chem. 1993 May 25;268(15):11372-9.

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