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Items: 1 to 20 of 128

1.

cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 2 (CRTC2) promotes glucagon clearance and hepatic amino acid catabolism to regulate glucose homeostasis.

Erion DM, Kotas ME, McGlashon J, Yonemitsu S, Hsiao JJ, Nagai Y, Iwasaki T, Murray SF, Bhanot S, Cline GW, Samuel VT, Shulman GI, Gillum MP.

J Biol Chem. 2013 May 31;288(22):16167-76. doi: 10.1074/jbc.M113.460246. Epub 2013 Apr 17.

2.

The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis.

Wang Y, Vera L, Fischer WH, Montminy M.

Nature. 2009 Jul 23;460(7254):534-7. doi: 10.1038/nature08111. Epub 2009 Jun 21.

3.

CRTC2 Is a Coactivator of GR and Couples GR and CREB in the Regulation of Hepatic Gluconeogenesis.

Hill MJ, Suzuki S, Segars JH, Kino T.

Mol Endocrinol. 2016 Jan;30(1):104-17. doi: 10.1210/me.2015-1237. Epub 2015 Dec 10.

4.

CRTC2 (TORC2) contributes to the transcriptional response to fasting in the liver but is not required for the maintenance of glucose homeostasis.

Le Lay J, Tuteja G, White P, Dhir R, Ahima R, Kaestner KH.

Cell Metab. 2009 Jul;10(1):55-62. doi: 10.1016/j.cmet.2009.06.006.

5.

Arginine methylation of CRTC2 is critical in the transcriptional control of hepatic glucose metabolism.

Han HS, Jung CY, Yoon YS, Choi S, Choi D, Kang G, Park KG, Kim ST, Koo SH.

Sci Signal. 2014 Feb 25;7(314):ra19. doi: 10.1126/scisignal.2004479.

PMID:
24570487
6.

Targeted disruption of the CREB coactivator Crtc2 increases insulin sensitivity.

Wang Y, Inoue H, Ravnskjaer K, Viste K, Miller N, Liu Y, Hedrick S, Vera L, Montminy M.

Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3087-92. doi: 10.1073/pnas.0914897107. Epub 2010 Jan 26.

7.

Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes.

Wang Y, Li G, Goode J, Paz JC, Ouyang K, Screaton R, Fischer WH, Chen J, Tabas I, Montminy M.

Nature. 2012 Apr 8;485(7396):128-32. doi: 10.1038/nature10988.

8.

A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange.

Liu Y, Dentin R, Chen D, Hedrick S, Ravnskjaer K, Schenk S, Milne J, Meyers DJ, Cole P, Yates J 3rd, Olefsky J, Guarente L, Montminy M.

Nature. 2008 Nov 13;456(7219):269-73. doi: 10.1038/nature07349. Epub 2008 Oct 5.

9.

AMPK-dependent repression of hepatic gluconeogenesis via disruption of CREB.CRTC2 complex by orphan nuclear receptor small heterodimer partner.

Lee JM, Seo WY, Song KH, Chanda D, Kim YD, Kim DK, Lee MW, Ryu D, Kim YH, Noh JR, Lee CH, Chiang JY, Koo SH, Choi HS.

J Biol Chem. 2010 Oct 15;285(42):32182-91. doi: 10.1074/jbc.M110.134890. Epub 2010 Aug 5.

10.

Study of CRTC2 pharmacology using antisense oligonuceotides.

Dullea R, Salatto C, Sciabola S, Chen T, Dimattia D, Gandhok H, Kreeger J, Weng Y, Clark T, Vage C, Stanton R.

Nucleic Acid Ther. 2014 Apr;24(2):127-38. doi: 10.1089/nat.2013.0456. Epub 2013 Dec 31.

PMID:
24380393
11.

Adiponectin and thiazolidinedione targets CRTC2 to regulate hepatic gluconeogenesis.

Yoon YS, Ryu D, Lee MW, Hong S, Koo SH.

Exp Mol Med. 2009 Aug 31;41(8):577-83. doi: 10.3858/emm.2009.41.8.063.

12.

Hepatic Insulin Resistance Following Chronic Activation of the CREB Coactivator CRTC2.

Hogan MF, Ravnskjaer K, Matsumura S, Huising MO, Hull RL, Kahn SE, Montminy M.

J Biol Chem. 2015 Oct 23;290(43):25997-6006. doi: 10.1074/jbc.M115.679266. Epub 2015 Sep 4.

13.

ATF3 mediates inhibitory effects of ethanol on hepatic gluconeogenesis.

Tsai WW, Matsumura S, Liu W, Phillips NG, Sonntag T, Hao E, Lee S, Hai T, Montminy M.

Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2699-704. doi: 10.1073/pnas.1424641112. Epub 2015 Feb 17.

14.

Suppressor of MEK null (SMEK)/protein phosphatase 4 catalytic subunit (PP4C) is a key regulator of hepatic gluconeogenesis.

Yoon YS, Lee MW, Ryu D, Kim JH, Ma H, Seo WY, Kim YN, Kim SS, Lee CH, Hunter T, Choi CS, Montminy MR, Koo SH.

Proc Natl Acad Sci U S A. 2010 Oct 12;107(41):17704-9. doi: 10.1073/pnas.1012665107. Epub 2010 Sep 27.

15.

Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects.

Ravnskjaer K, Hogan MF, Lackey D, Tora L, Dent SY, Olefsky J, Montminy M.

J Clin Invest. 2013 Oct;123(10):4318-28. doi: 10.1172/JCI69035. Epub 2013 Sep 24.

16.

Orphan nuclear receptor estrogen-related receptor γ (ERRγ) is key regulator of hepatic gluconeogenesis.

Kim DK, Ryu D, Koh M, Lee MW, Lim D, Kim MJ, Kim YH, Cho WJ, Lee CH, Park SB, Koo SH, Choi HS.

J Biol Chem. 2012 Jun 22;287(26):21628-39. doi: 10.1074/jbc.M111.315168. Epub 2012 May 1.

17.

Dual role of the coactivator TORC2 in modulating hepatic glucose output and insulin signaling.

Canettieri G, Koo SH, Berdeaux R, Heredia J, Hedrick S, Zhang X, Montminy M.

Cell Metab. 2005 Nov;2(5):331-8.

18.

p38 Mitogen-activated protein kinase plays a stimulatory role in hepatic gluconeogenesis.

Cao W, Collins QF, Becker TC, Robidoux J, Lupo EG Jr, Xiong Y, Daniel KW, Floering L, Collins S.

J Biol Chem. 2005 Dec 30;280(52):42731-7. Epub 2005 Nov 3.

19.

Hepatic glucose sensing via the CREB coactivator CRTC2.

Dentin R, Hedrick S, Xie J, Yates J 3rd, Montminy M.

Science. 2008 Mar 7;319(5868):1402-5. doi: 10.1126/science.1151363.

20.

CREB regulates hepatic gluconeogenesis through the coactivator PGC-1.

Herzig S, Long F, Jhala US, Hedrick S, Quinn R, Bauer A, Rudolph D, Schutz G, Yoon C, Puigserver P, Spiegelman B, Montminy M.

Nature. 2001 Sep 13;413(6852):179-83. Erratum in: Nature 2001 Oct 11;413(6856):652.

PMID:
11557984

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