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LHX2 is necessary for the maintenance of optic identity and for the progression of optic morphogenesis.

Roy A, de Melo J, Chaturvedi D, Thein T, Cabrera-Socorro A, Houart C, Meyer G, Blackshaw S, Tole S.

J Neurosci. 2013 Apr 17;33(16):6877-84. doi: 10.1523/JNEUROSCI.4216-12.2013.


The LIM homeobox transcription factor Lhx2 is required to specify the retina field and synergistically cooperates with Pax6 for Six6 trans-activation.

TĂ©treault N, Champagne MP, Bernier G.

Dev Biol. 2009 Mar 15;327(2):541-50. doi: 10.1016/j.ydbio.2008.12.022.


Lhx2 links the intrinsic and extrinsic factors that control optic cup formation.

Yun S, Saijoh Y, Hirokawa KE, Kopinke D, Murtaugh LC, Monuki ES, Levine EM.

Development. 2009 Dec;136(23):3895-906. doi: 10.1242/dev.041202.


COUP-TFs regulate eye development by controlling factors essential for optic vesicle morphogenesis.

Tang K, Xie X, Park JI, Jamrich M, Tsai S, Tsai MJ.

Development. 2010 Mar;137(5):725-34. doi: 10.1242/dev.040568.


Lhx2 regulates a cortex-specific mechanism for barrel formation.

Shetty AS, Godbole G, Maheshwari U, Padmanabhan H, Chaudhary R, Muralidharan B, Hou PS, Monuki ES, Kuo HC, Rema V, Tole S.

Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):E4913-21. doi: 10.1073/pnas.1311158110.


Specification of the vertebrate eye by a network of eye field transcription factors.

Zuber ME, Gestri G, Viczian AS, Barsacchi G, Harris WA.

Development. 2003 Nov;130(21):5155-67.


Reprogramming fibroblasts to neural-precursor-like cells by structured overexpression of pallial patterning genes.

Raciti M, Granzotto M, Duc MD, Fimiani C, Cellot G, Cherubini E, Mallamaci A.

Mol Cell Neurosci. 2013 Nov;57:42-53. doi: 10.1016/j.mcn.2013.10.004.


Lhx2, a LIM homeobox gene, is required for eye, forebrain, and definitive erythrocyte development.

Porter FD, Drago J, Xu Y, Cheema SS, Wassif C, Huang SP, Lee E, Grinberg A, Massalas JS, Bodine D, Alt F, Westphal H.

Development. 1997 Aug;124(15):2935-44.


Lhx2 is required for patterning and expansion of a distinct progenitor cell population committed to eye development.

Hägglund AC, Dahl L, Carlsson L.

PLoS One. 2011;6(8):e23387. doi: 10.1371/journal.pone.0023387.


Stage-dependent requirement of neuroretinal Pax6 for lens and retina development.

Klimova L, Kozmik Z.

Development. 2014 Mar;141(6):1292-302. doi: 10.1242/dev.098822.


Multiple requirements for Hes 1 during early eye formation.

Lee HY, Wroblewski E, Philips GT, Stair CN, Conley K, Reedy M, Mastick GS, Brown NL.

Dev Biol. 2005 Aug 15;284(2):464-78.


Precocious retinal neurons: Pax6 controls timing of differentiation and determination of cell type.

Philips GT, Stair CN, Young Lee H, Wroblewski E, Berberoglu MA, Brown NL, Mastick GS.

Dev Biol. 2005 Mar 15;279(2):308-21.


Normal ventral telencephalic expression of Pax6 is required for normal development of thalamocortical axons in embryonic mice.

Simpson TI, Pratt T, Mason JO, Price DJ.

Neural Dev. 2009 Jun 5;4:19. doi: 10.1186/1749-8104-4-19.


Lhx2 regulates the development of the forebrain hem system.

Roy A, Gonzalez-Gomez M, Pierani A, Meyer G, Tole S.

Cereb Cortex. 2014 May;24(5):1361-72. doi: 10.1093/cercor/bhs421.


Agenesis of the Corpus Callosum Due to Defective Glial Wedge Formation in Lhx2 Mutant Mice.

Chinn GA, Hirokawa KE, Chuang TM, Urbina C, Patel F, Fong J, Funatsu N, Monuki ES.

Cereb Cortex. 2015 Sep;25(9):2707-18. doi: 10.1093/cercor/bhu067.


Pax6 is required at the telencephalic pallial-subpallial boundary for the generation of neuronal diversity in the postnatal limbic system.

Cocas LA, Georgala PA, Mangin JM, Clegg JM, Kessaris N, Haydar TF, Gallo V, Price DJ, Corbin JG.

J Neurosci. 2011 Apr 6;31(14):5313-24. doi: 10.1523/JNEUROSCI.3867-10.2011.


LHX2 regulates the neural differentiation of human embryonic stem cells via transcriptional modulation of PAX6 and CER1.

Hou PS, Chuang CY, Kao CF, Chou SJ, Stone L, Ho HN, Chien CL, Kuo HC.

Nucleic Acids Res. 2013 Sep;41(16):7753-70. doi: 10.1093/nar/gkt567.


Spatial specification of mammalian eye territories by reciprocal transcriptional repression of Pax2 and Pax6.

Schwarz M, Cecconi F, Bernier G, Andrejewski N, Kammandel B, Wagner M, Gruss P.

Development. 2000 Oct;127(20):4325-34.


The involvement of neural retina pax6 in lens fiber differentiation.

Reza HM, Yasuda K.

Dev Neurosci. 2004;26(5-6):318-27.


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