Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 96


Structural basis of protein phosphatase 2A stable latency.

Jiang L, Stanevich V, Satyshur KA, Kong M, Watkins GR, Wadzinski BE, Sengupta R, Xing Y.

Nat Commun. 2013;4:1699. doi: 10.1038/ncomms2663.


The E3 ubiquitin ligase- and protein phosphatase 2A (PP2A)-binding domains of the Alpha4 protein are both required for Alpha4 to inhibit PP2A degradation.

LeNoue-Newton M, Watkins GR, Zou P, Germane KL, McCorvey LR, Wadzinski BE, Spiller BW.

J Biol Chem. 2011 May 20;286(20):17665-71. doi: 10.1074/jbc.M111.222414. Epub 2011 Mar 29.


Mechanisms of the scaffold subunit in facilitating protein phosphatase 2A methylation.

Stanevich V, Zheng A, Guo F, Jiang L, Wlodarchak N, Xing Y.

PLoS One. 2014 Jan 23;9(1):e86955. doi: 10.1371/journal.pone.0086955. eCollection 2014.


MID1 catalyzes the ubiquitination of protein phosphatase 2A and mutations within its Bbox1 domain disrupt polyubiquitination of alpha4 but not of PP2Ac.

Du H, Wu K, Didoronkute A, Levy MV, Todi N, Shchelokova A, Massiah MA.

PLoS One. 2014 Sep 10;9(9):e107428. doi: 10.1371/journal.pone.0107428. eCollection 2014.


Alpha4 is a ubiquitin-binding protein that regulates protein serine/threonine phosphatase 2A ubiquitination.

McConnell JL, Watkins GR, Soss SE, Franz HS, McCorvey LR, Spiller BW, Chazin WJ, Wadzinski BE.

Biochemistry. 2010 Mar 2;49(8):1713-8. doi: 10.1021/bi901837h.


The MID1 E3 ligase catalyzes the polyubiquitination of Alpha4 (α4), a regulatory subunit of protein phosphatase 2A (PP2A): novel insights into MID1-mediated regulation of PP2A.

Du H, Huang Y, Zaghlula M, Walters E, Cox TC, Massiah MA.

J Biol Chem. 2013 Jul 19;288(29):21341-50. doi: 10.1074/jbc.M113.481093. Epub 2013 Jun 5.


Progestin-inducible EDD E3 ubiquitin ligase binds to α4 phosphoprotein to regulate ubiquitination and degradation of protein phosphatase PP2Ac.

McDonald WJ, Thomas LN, Koirala S, Too CK.

Mol Cell Endocrinol. 2014 Jan 25;382(1):254-61. doi: 10.1016/j.mce.2013.09.033. Epub 2013 Oct 18.


Monoubiquitination promotes calpain cleavage of the protein phosphatase 2A (PP2A) regulatory subunit α4, altering PP2A stability and microtubule-associated protein phosphorylation.

Watkins GR, Wang N, Mazalouskas MD, Gomez RJ, Guthrie CR, Kraemer BC, Schweiger S, Spiller BW, Wadzinski BE.

J Biol Chem. 2012 Jul 13;287(29):24207-15. doi: 10.1074/jbc.M112.368613. Epub 2012 May 21.


The structure of Tap42/alpha4 reveals a tetratricopeptide repeat-like fold and provides insights into PP2A regulation.

Yang J, Roe SM, Prickett TD, Brautigan DL, Barford D.

Biochemistry. 2007 Jul 31;46(30):8807-15. Epub 2007 Jul 6.


Assembly and structure of protein phosphatase 2A.

Shi Y.

Sci China C Life Sci. 2009 Feb;52(2):135-46. doi: 10.1007/s11427-009-0018-3. Epub 2009 Mar 11. Review.


The three Type 2A protein phosphatases, PP2Ac, PP4c and PP6c, are differentially regulated by Alpha4.

LeNoue-Newton ML, Wadzinski BE, Spiller BW.

Biochem Biophys Res Commun. 2016 Jun 17;475(1):64-9. doi: 10.1016/j.bbrc.2016.05.036. Epub 2016 May 8.


I1PP2A affects tau phosphorylation via association with the catalytic subunit of protein phosphatase 2A.

Chen S, Li B, Grundke-Iqbal I, Iqbal K.

J Biol Chem. 2008 Apr 18;283(16):10513-21. doi: 10.1074/jbc.M709852200. Epub 2008 Feb 1.


NMR studies of the C-terminus of alpha4 reveal possible mechanism of its interaction with MID1 and protein phosphatase 2A.

Du H, Massiah MA.

PLoS One. 2011;6(12):e28877. doi: 10.1371/journal.pone.0028877. Epub 2011 Dec 14.


Structural mechanism of demethylation and inactivation of protein phosphatase 2A.

Xing Y, Li Z, Chen Y, Stock JB, Jeffrey PD, Shi Y.

Cell. 2008 Apr 4;133(1):154-63. doi: 10.1016/j.cell.2008.02.041.


Protein Phosphatase Methyl-Esterase PME-1 Protects Protein Phosphatase 2A from Ubiquitin/Proteasome Degradation.

Yabe R, Miura A, Usui T, Mudrak I, Ogris E, Ohama T, Sato K.

PLoS One. 2015 Dec 17;10(12):e0145226. doi: 10.1371/journal.pone.0145226. eCollection 2015.


Parallel purification of three catalytic subunits of the protein serine/threonine phosphatase 2A family (PP2A(C), PP4(C), and PP6(C)) and analysis of the interaction of PP2A(C) with alpha4 protein.

Kloeker S, Reed R, McConnell JL, Chang D, Tran K, Westphal RS, Law BK, Colbran RJ, Kamoun M, Campbell KS, Wadzinski BE.

Protein Expr Purif. 2003 Sep;31(1):19-33.


Structure of the Ca2+-dependent PP2A heterotrimer and insights into Cdc6 dephosphorylation.

Wlodarchak N, Guo F, Satyshur KA, Jiang L, Jeffrey PD, Sun T, Stanevich V, Mumby MC, Xing Y.

Cell Res. 2013 Jul;23(7):931-46. doi: 10.1038/cr.2013.77. Epub 2013 Jun 11.


Supplemental Content

Support Center