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Activation of Liver FGF21 in hepatocarcinogenesis and during hepatic stress.

Yang C, Lu W, Lin T, You P, Ye M, Huang Y, Jiang X, Wang C, Wang F, Lee MH, Yeung SC, Johnson RL, Wei C, Tsai RY, Frazier ML, McKeehan WL, Luo Y.

BMC Gastroenterol. 2013 Apr 17;13:67. doi: 10.1186/1471-230X-13-67.


Forced expression of hepatocyte-specific fibroblast growth factor 21 delays initiation of chemically induced hepatocarcinogenesis.

Huang X, Yu C, Jin C, Yang C, Xie R, Cao D, Wang F, McKeehan WL.

Mol Carcinog. 2006 Dec;45(12):934-42.


Differential specificity of endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in complex with KLB.

Yang C, Jin C, Li X, Wang F, McKeehan WL, Luo Y.

PLoS One. 2012;7(3):e33870. doi: 10.1371/journal.pone.0033870. Epub 2012 Mar 19.


Fibroblast growth factor 21 participates in adaptation to endoplasmic reticulum stress and attenuates obesity-induced hepatic metabolic stress.

Kim SH, Kim KH, Kim HK, Kim MJ, Back SH, Konishi M, Itoh N, Lee MS.

Diabetologia. 2015 Apr;58(4):809-18. doi: 10.1007/s00125-014-3475-6. Epub 2014 Dec 24.


Fibroblast growth factor 21 is regulated by the IRE1α-XBP1 branch of the unfolded protein response and counteracts endoplasmic reticulum stress-induced hepatic steatosis.

Jiang S, Yan C, Fang QC, Shao ML, Zhang YL, Liu Y, Deng YP, Shan B, Liu JQ, Li HT, Yang L, Zhou J, Dai Z, Liu Y, Jia WP.

J Biol Chem. 2014 Oct 24;289(43):29751-65. doi: 10.1074/jbc.M114.565960. Epub 2014 Aug 28.


Induction of p53 renders ATM-deficient mice refractory to hepatocarcinogenesis.

Teoh N, Pyakurel P, Dan YY, Swisshelm K, Hou J, Mitchell C, Fausto N, Gu Y, Farrell G.

Gastroenterology. 2010 Mar;138(3):1155-65.e1-2. doi: 10.1053/j.gastro.2009.11.008. Epub 2009 Nov 14.


Fibroblast growth factor 21, fibroblast growth factor receptor 1, and β-Klotho expression in bovine growth hormone transgenic and growth hormone receptor knockout mice.

Brooks NE, Hjortebjerg R, Henry BE, List EO, Kopchick JJ, Berryman DE.

Growth Horm IGF Res. 2016 Oct - Dec;30-31:22-30. doi: 10.1016/j.ghir.2016.08.003. Epub 2016 Aug 24.


Serine 727 phosphorylation of STAT3: an early change in mouse hepatocarcinogenesis induced by neonatal treatment with diethylnitrosamine.

Miyakoshi M, Yamamoto M, Tanaka H, Ogawa K.

Mol Carcinog. 2014 Jan;53(1):67-76. doi: 10.1002/mc.21949. Epub 2012 Aug 21.


Astrocyte elevated gene-1 promotes hepatocarcinogenesis: novel insights from a mouse model.

Srivastava J, Siddiq A, Emdad L, Santhekadur PK, Chen D, Gredler R, Shen XN, Robertson CL, Dumur CI, Hylemon PB, Mukhopadhyay ND, Bhere D, Shah K, Ahmad R, Giashuddin S, Stafflinger J, Subler MA, Windle JJ, Fisher PB, Sarkar D.

Hepatology. 2012 Nov;56(5):1782-91. doi: 10.1002/hep.25868.


Control of lipid metabolism by adipocyte FGFR1-mediated adipohepatic communication during hepatic stress.

Yang C, Wang C, Ye M, Jin C, He W, Wang F, McKeehan WL, Luo Y.

Nutr Metab (Lond). 2012 Oct 30;9(1):94. doi: 10.1186/1743-7075-9-94.


Lack of overt FGF21 resistance in two mouse models of obesity and insulin resistance.

Hale C, Chen MM, Stanislaus S, Chinookoswong N, Hager T, Wang M, Véniant MM, Xu J.

Endocrinology. 2012 Jan;153(1):69-80. doi: 10.1210/en.2010-1262. Epub 2011 Nov 8.


Hepatic transforming growth factor beta gives rise to tumor-initiating cells and promotes liver cancer development.

Wu K, Ding J, Chen C, Sun W, Ning BF, Wen W, Huang L, Han T, Yang W, Wang C, Li Z, Wu MC, Feng GS, Xie WF, Wang HY.

Hepatology. 2012 Dec;56(6):2255-67. doi: 10.1002/hep.26007.


Transcriptional repressor E4-binding protein 4 (E4BP4) regulates metabolic hormone fibroblast growth factor 21 (FGF21) during circadian cycles and feeding.

Tong X, Muchnik M, Chen Z, Patel M, Wu N, Joshi S, Rui L, Lazar MA, Yin L.

J Biol Chem. 2010 Nov 19;285(47):36401-9. doi: 10.1074/jbc.M110.172866. Epub 2010 Sep 17.


PPARalpha is a key regulator of hepatic FGF21.

Lundåsen T, Hunt MC, Nilsson LM, Sanyal S, Angelin B, Alexson SE, Rudling M.

Biochem Biophys Res Commun. 2007 Aug 24;360(2):437-40. Epub 2007 Jun 21.


FGF21-FGFR1 Coordinates Phospholipid Homeostasis, Lipid Droplet Function, and ER Stress in Obesity.

Ye M, Lu W, Wang X, Wang C, Abbruzzese JL, Liang G, Li X, Luo Y.

Endocrinology. 2016 Dec;157(12):4754-4769. Epub 2016 Oct 3.


Hepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21.

Cornu M, Oppliger W, Albert V, Robitaille AM, Trapani F, Quagliata L, Fuhrer T, Sauer U, Terracciano L, Hall MN.

Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11592-9. doi: 10.1073/pnas.1412047111. Epub 2014 Jul 31.


Dynamic metabolic change is indicative of inflammation-induced transformation of hepatic cells.

Peng B, Liu F, Han R, Luo G, Cathopoulis T, Lu K, Li X, Yang L, Liu GY, Cai JC, Shi SL.

Int J Biochem Cell Biol. 2015 Sep;66:45-58. doi: 10.1016/j.biocel.2015.07.007. Epub 2015 Jul 20.


Quantitative analysis of hepatic hypoxia-inducible factor-1alpha and its abnormal gene expression during the formation of hepatocellular carcinoma.

Yao DF, Jiang H, Yao M, Li YM, Gu WJ, Shen YC, Qiu LW, Wu W, Wu XH, Sai WL.

Hepatobiliary Pancreat Dis Int. 2009 Aug;8(4):407-13.


Growth hormone induces hepatic production of fibroblast growth factor 21 through a mechanism dependent on lipolysis in adipocytes.

Chen W, Hoo RL, Konishi M, Itoh N, Lee PC, Ye HY, Lam KS, Xu A.

J Biol Chem. 2011 Oct 7;286(40):34559-66. doi: 10.1074/jbc.M111.285965. Epub 2011 Aug 17.


Physiology and Endocrinology Symposium: FGF21: Insights into mechanism of action from preclinical studies.

Antonellis PJ, Kharitonenkov A, Adams AC.

J Anim Sci. 2014 Feb;92(2):407-13. doi: 10.2527/jas.2013-7076. Epub 2014 Jan 7.


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