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Items: 1 to 20 of 98

1.

Emerging transporters of clinical importance: an update from the International Transporter Consortium.

Hillgren KM, Keppler D, Zur AA, Giacomini KM, Stieger B, Cass CE, Zhang L; International Transporter Consortium.

Clin Pharmacol Ther. 2013 Jul;94(1):52-63. doi: 10.1038/clpt.2013.74. Epub 2013 Apr 8. Review.

PMID:
23588305
2.

Highlights from the International Transporter Consortium second workshop.

Zamek-Gliszczynski MJ, Hoffmaster KA, Tweedie DJ, Giacomini KM, Hillgren KM.

Clin Pharmacol Ther. 2012 Nov;92(5):553-6. doi: 10.1038/clpt.2012.126.

PMID:
23085880
3.
4.

Transporter studies in drug development: experience to date and follow-up on decision trees from the International Transporter Consortium.

Tweedie D, Polli JW, Berglund EG, Huang SM, Zhang L, Poirier A, Chu X, Feng B; International Transporter Consortium.

Clin Pharmacol Ther. 2013 Jul;94(1):113-25. doi: 10.1038/clpt.2013.77. Epub 2013 Apr 10. Review.

PMID:
23588318
5.

Drug transport proteins in the liver.

Faber KN, Müller M, Jansen PL.

Adv Drug Deliv Rev. 2003 Jan 21;55(1):107-24. Review.

PMID:
12535576
6.

The kidney--the body's playground for drugs: an overview of renal drug handling with selected clinical correlates.

Perri D, Ito S, Rowsell V, Shear NH.

Can J Clin Pharmacol. 2003 Spring;10(1):17-23. Review.

PMID:
12687033
7.

Prediction of pharmacokinetics and drug-drug interactions when hepatic transporters are involved.

Li R, Barton HA, Varma MV.

Clin Pharmacokinet. 2014 Aug;53(8):659-78. doi: 10.1007/s40262-014-0156-z. Review.

PMID:
25056496
8.

Cholestasis and the role of basolateral efflux pumps.

Keppler D.

Z Gastroenterol. 2011 Jul;49(12):1553-7. doi: 10.1055/s-0031-1281755. Epub 2011 Dec 2. Review.

PMID:
22139880
9.

In vitro and in vivo approaches to characterize transporter-mediated disposition in drug discovery.

Feng B, Varma MV, Costales C, Zhang H, Tremaine L.

Expert Opin Drug Discov. 2014 Aug;9(8):873-90. doi: 10.1517/17460441.2014.922540. Epub 2014 May 24. Review.

PMID:
24857286
10.

The complexities of hepatic drug transport: current knowledge and emerging concepts.

Chandra P, Brouwer KL.

Pharm Res. 2004 May;21(5):719-35. Review.

PMID:
15180326
11.

Multidrug resistance proteins (MRPs, ABCCs): importance for pathophysiology and drug therapy.

Keppler D.

Handb Exp Pharmacol. 2011;(201):299-323. doi: 10.1007/978-3-642-14541-4_8. Review.

PMID:
21103974
12.

Regulation of drug transporter expression in human hepatocytes exposed to the proinflammatory cytokines tumor necrosis factor-alpha or interleukin-6.

Le Vee M, Lecureur V, Stieger B, Fardel O.

Drug Metab Dispos. 2009 Mar;37(3):685-93. doi: 10.1124/dmd.108.023630. Epub 2008 Dec 15.

13.

Effects of Drug Transporters on Pharmacological Responses and Safety.

Liu CX, Yi XL, Fan HR, Wu WD, Zhang X, Xiao XF, He X.

Curr Drug Metab. 2015;16(9):732-52. Review.

PMID:
26630905
14.

Transporter-mediated tissue targeting of therapeutic molecules in drug discovery.

Zhou J, Xu J, Huang Z, Wang M.

Bioorg Med Chem Lett. 2015 Mar 1;25(5):993-7. doi: 10.1016/j.bmcl.2015.01.016. Epub 2015 Jan 24. Review.

15.

Evaluation of drug transporter interactions in drug discovery and development.

Lai Y, Sampson KE, Stevens JC.

Comb Chem High Throughput Screen. 2010 Feb;13(2):112-34. Review.

PMID:
20053160
16.

Development of novel, 384-well high-throughput assay panels for human drug transporters: drug interaction and safety assessment in support of discovery research.

Tang H, Shen DR, Han YH, Kong Y, Balimane P, Marino A, Gao M, Wu S, Xie D, Soars MG, O'Connell JC, Rodrigues AD, Zhang L, Cvijic ME.

J Biomol Screen. 2013 Oct;18(9):1072-83. doi: 10.1177/1087057113494807.

PMID:
24062352
17.

[Effect of genetic polymorphism on the activity of drug transporters and its clinical significance].

Zhang HX, Wang LS.

Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2008 Aug;33(8):765-9. Review. Chinese.

18.

Stereoselectivity of chiral drug transport: a focus on enantiomer-transporter interaction.

Zhou Q, Yu LS, Zeng S.

Drug Metab Rev. 2014 Aug;46(3):283-90. doi: 10.3109/03602532.2014.887094. Epub 2014 May 6. Review.

PMID:
24796860
19.

Multidrug and toxin extrusion proteins (MATE/SLC47); role in pharmacokinetics.

Staud F, Cerveny L, Ahmadimoghaddam D, Ceckova M.

Int J Biochem Cell Biol. 2013 Sep;45(9):2007-11. doi: 10.1016/j.biocel.2013.06.022. Epub 2013 Jul 5. Review.

PMID:
23831838
20.

Transporters and drug-drug interactions: important determinants of drug disposition and effects.

König J, Müller F, Fromm MF.

Pharmacol Rev. 2013 May 17;65(3):944-66. doi: 10.1124/pr.113.007518. Print 2013 Jul. Review.

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